Inducibility of ventricular arrhythmias in early repolarization syndrome and Brugada syndrome: From the J-wave associated with prior cardiac event (J-PREVENT) registry
Background: Although electrophysiological study is often performed in Brugada syndrome (BrS) to assess inducibility of ventricular arrhythmias (VA), the utility of electrophysiological study in early repolarization syndrome (ERS) remains unknown. The aim of the present multi-center observational stu...
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| Format: | Article |
| Language: | English |
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Wiley
2014-08-01
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| Series: | Journal of Arrhythmia |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1880427614000398 |
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| author | Yoshihide Takahashi, MD Yuki Osaka, MD Akihiko Nogami, MD Mitsuhiro Nishizaki, MD Kaoru Okishige, MD Makoto Suzuki, MD Yasuteru Yamauchi, MD Yuichi Ono, MD Kou Suzuki, MD Kenzo Hirao, MD Mitsuaki Isobe, MD |
| author_facet | Yoshihide Takahashi, MD Yuki Osaka, MD Akihiko Nogami, MD Mitsuhiro Nishizaki, MD Kaoru Okishige, MD Makoto Suzuki, MD Yasuteru Yamauchi, MD Yuichi Ono, MD Kou Suzuki, MD Kenzo Hirao, MD Mitsuaki Isobe, MD |
| author_sort | Yoshihide Takahashi, MD |
| collection | DOAJ |
| description | Background: Although electrophysiological study is often performed in Brugada syndrome (BrS) to assess inducibility of ventricular arrhythmias (VA), the utility of electrophysiological study in early repolarization syndrome (ERS) remains unknown. The aim of the present multi-center observational study was to compare inducibility of VA in ERS with BrS, and to investigate any association between inducibility and recurrence of arrhythmic events in these patients.
Methods: The J-PREVENT registry consists of patients with early repolarization or Brugada type 1 ECGs, a history of prior cardiac events, and no structural heart disease. Patients in the registry with implantable cardioverter-defibrillators (ICDs) and who underwent electrophysiological study were enrolled. VA inducibility was assessed by programmed electrical stimulation performed at two different sites in the right ventricle with up to three extrastimuli. The occurrence of VA during follow-up was determined by interrogation of the patients׳ ICDs.
Results: Of the 79 patients studied (72 males, mean age 44±13 years), 21 patients (27%) had ERS, and 58 had BrS, 20 of whom also had early repolarization in the inferolateral leads. VA was induced in 9 patients (43%) and 45 (78%) with ERS and BrS, respectively (p=0.006). During a median follow-up of 1453 days, occurrence rate of VA was similar between ERS and BrS (p=0.35). Inducibility was not associated with occurrence of VA in either syndrome.
Conclusions: In patients with ERS with prior history of cardiac events, VA was induced in 43% of patients during electrophysiological study, approximately half that of BrS. Inducibility was not associated with occurrence of VA during follow-up, although this was true of BrS patients as well. Electrophysiological study may play a limited role in risk stratification in ERS. |
| first_indexed | 2024-04-12T19:26:37Z |
| format | Article |
| id | doaj.art-bbe51cfa53e9453eb95ea344c401d43f |
| institution | Directory Open Access Journal |
| issn | 1880-4276 |
| language | English |
| last_indexed | 2024-04-12T19:26:37Z |
| publishDate | 2014-08-01 |
| publisher | Wiley |
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| series | Journal of Arrhythmia |
| spelling | doaj.art-bbe51cfa53e9453eb95ea344c401d43f2022-12-22T03:19:27ZengWileyJournal of Arrhythmia1880-42762014-08-0130430030410.1016/j.joa.2014.03.004Inducibility of ventricular arrhythmias in early repolarization syndrome and Brugada syndrome: From the J-wave associated with prior cardiac event (J-PREVENT) registryYoshihide Takahashi, MD0Yuki Osaka, MD1Akihiko Nogami, MD2Mitsuhiro Nishizaki, MD3Kaoru Okishige, MD4Makoto Suzuki, MD5Yasuteru Yamauchi, MD6Yuichi Ono, MD7Kou Suzuki, MD8Kenzo Hirao, MD9Mitsuaki Isobe, MD10The Department of Cardiovascular Medicine, National Disaster Medical Center, Midoricho 3256, Tachikawa, Tokyo 190-0014, JapanCardiovascular Center, Yokosuka Kyousai Hospital, Yokosuka, JapanDivision of Cardiology, Yokohama Rosai Hospital, Yokohama, JapanDepartment of Cardiovascular Medicine, Yokohama Minami Kyousai Hospital, Yokohama, JapanDepartment of Cardiovascular Medicine, Yokohama Bayside Red Cross Hospital, Yokohama, JapanDepartment of Cardiovascular Medicine, Kameda General Hospital, Kamogawa, JapanDepartment of Cardiovascular Medicine, Musashino Red Cross Hospital, Tokyo, JapanDepartment of Cardiovascular Medicine, Ome General Hospital, Tokyo, JapanDepartment of Cardiology, Tokyo Metropolitan Bokutoh Hospital, Tokyo, JapanHeart Rhythm Center, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, JapanBackground: Although electrophysiological study is often performed in Brugada syndrome (BrS) to assess inducibility of ventricular arrhythmias (VA), the utility of electrophysiological study in early repolarization syndrome (ERS) remains unknown. The aim of the present multi-center observational study was to compare inducibility of VA in ERS with BrS, and to investigate any association between inducibility and recurrence of arrhythmic events in these patients. Methods: The J-PREVENT registry consists of patients with early repolarization or Brugada type 1 ECGs, a history of prior cardiac events, and no structural heart disease. Patients in the registry with implantable cardioverter-defibrillators (ICDs) and who underwent electrophysiological study were enrolled. VA inducibility was assessed by programmed electrical stimulation performed at two different sites in the right ventricle with up to three extrastimuli. The occurrence of VA during follow-up was determined by interrogation of the patients׳ ICDs. Results: Of the 79 patients studied (72 males, mean age 44±13 years), 21 patients (27%) had ERS, and 58 had BrS, 20 of whom also had early repolarization in the inferolateral leads. VA was induced in 9 patients (43%) and 45 (78%) with ERS and BrS, respectively (p=0.006). During a median follow-up of 1453 days, occurrence rate of VA was similar between ERS and BrS (p=0.35). Inducibility was not associated with occurrence of VA in either syndrome. Conclusions: In patients with ERS with prior history of cardiac events, VA was induced in 43% of patients during electrophysiological study, approximately half that of BrS. Inducibility was not associated with occurrence of VA during follow-up, although this was true of BrS patients as well. Electrophysiological study may play a limited role in risk stratification in ERS.http://www.sciencedirect.com/science/article/pii/S1880427614000398Early repolarizationBrugada syndromeElectrophysiological study |
| spellingShingle | Yoshihide Takahashi, MD Yuki Osaka, MD Akihiko Nogami, MD Mitsuhiro Nishizaki, MD Kaoru Okishige, MD Makoto Suzuki, MD Yasuteru Yamauchi, MD Yuichi Ono, MD Kou Suzuki, MD Kenzo Hirao, MD Mitsuaki Isobe, MD Inducibility of ventricular arrhythmias in early repolarization syndrome and Brugada syndrome: From the J-wave associated with prior cardiac event (J-PREVENT) registry Journal of Arrhythmia Early repolarization Brugada syndrome Electrophysiological study |
| title | Inducibility of ventricular arrhythmias in early repolarization syndrome and Brugada syndrome: From the J-wave associated with prior cardiac event (J-PREVENT) registry |
| title_full | Inducibility of ventricular arrhythmias in early repolarization syndrome and Brugada syndrome: From the J-wave associated with prior cardiac event (J-PREVENT) registry |
| title_fullStr | Inducibility of ventricular arrhythmias in early repolarization syndrome and Brugada syndrome: From the J-wave associated with prior cardiac event (J-PREVENT) registry |
| title_full_unstemmed | Inducibility of ventricular arrhythmias in early repolarization syndrome and Brugada syndrome: From the J-wave associated with prior cardiac event (J-PREVENT) registry |
| title_short | Inducibility of ventricular arrhythmias in early repolarization syndrome and Brugada syndrome: From the J-wave associated with prior cardiac event (J-PREVENT) registry |
| title_sort | inducibility of ventricular arrhythmias in early repolarization syndrome and brugada syndrome from the j wave associated with prior cardiac event j prevent registry |
| topic | Early repolarization Brugada syndrome Electrophysiological study |
| url | http://www.sciencedirect.com/science/article/pii/S1880427614000398 |
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