Inflammatory cytokines dysfunction in autism spectrum disorder
Introduction Autism spectrum disorder (ASD) is a common neurodevelopmental disorder. Its underlying causes and pathophysiologies remain unclear. Recent data support the potential involvement of neuroinflammation in the onset of this disorder. Objectives The aim of our study was to investigate th...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2021-04-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S092493382100571X/type/journal_article |
| _version_ | 1797617436476833792 |
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| author | A. Ben Othman H. Slama E. Cherif M. Azaiez H. Gharsallah |
| author_facet | A. Ben Othman H. Slama E. Cherif M. Azaiez H. Gharsallah |
| author_sort | A. Ben Othman |
| collection | DOAJ |
| description |
Introduction
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder. Its underlying causes and pathophysiologies remain unclear. Recent data support the potential involvement of neuroinflammation in the onset of this disorder.
Objectives
The aim of our study was to investigate the potential link between ASD and inflammatory mediators.
Methods
This descriptive study was conducted among ASD outpatients followed-up at the child and adolescent psychiatry department in the Military Hospital of Instruction of Tunis. Blood samples were collected for inflammatory cytokines dosage, notably the interleukin 1β (IL-1β), interleukin 6 (IL-6) and the Tumor Necrosis Factor α (TNF-α) immunodosage.
Results
Twenty-four patients were included in this study, aged between four and ten years old (mean age= 6,55 years; minimum=4; maximum=10 years). Our sample was mainly represented by male patients (95,6%). TNF-α plasmatic levels were high (>5pg/mL) among all of our sample with a mean of 11,6 pg/mL (minimum= 6,87; maximum=17,7 pg/mL; standard deviation= 3,52 pg/mL), suggesting abnormal peripheral blood mononuclear cells response. However, IL-1β and IL-6 plasmatic levels were relatively normal.
Conclusions
An immune response dysregulation was detected in our sample. Multiple clinical and experimental studies investigated the implication of inflammatory cytokines in neurodevelopmental disruption. Their results, however, remain controversial and limited by small samples. Further studies need to be done in order to investigate the neuroimmunological factors linked with ASD.
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| first_indexed | 2024-03-11T07:55:59Z |
| format | Article |
| id | doaj.art-bbe89adeee7f41068ac352b6dafabd84 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:55:59Z |
| publishDate | 2021-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-bbe89adeee7f41068ac352b6dafabd842023-11-17T05:05:45ZengCambridge University PressEuropean Psychiatry0924-93381778-35852021-04-0164S214S21510.1192/j.eurpsy.2021.571Inflammatory cytokines dysfunction in autism spectrum disorderA. Ben Othman0H. Slama1E. Cherif2M. Azaiez3H. Gharsallah4Child And Adolescent Psychiatry, Military Hospital of Instruction of Tunis, Tunis, TunisiaChild And Adolescent Psychiatry, Military Hospital of Instruction of Tunis, Tunis, TunisiaChild And Adolescent Psychiatry, Military Hospital of Instruction of Tunis, Tunis, TunisiaChild And Adolescent Psychiatry, Military Hospital of Instruction of Tunis, Tunis, TunisiaAnesthesiology And Intensive Therapy, Military Hospital of Instruction of Tunis, Tunis, Tunisia Introduction Autism spectrum disorder (ASD) is a common neurodevelopmental disorder. Its underlying causes and pathophysiologies remain unclear. Recent data support the potential involvement of neuroinflammation in the onset of this disorder. Objectives The aim of our study was to investigate the potential link between ASD and inflammatory mediators. Methods This descriptive study was conducted among ASD outpatients followed-up at the child and adolescent psychiatry department in the Military Hospital of Instruction of Tunis. Blood samples were collected for inflammatory cytokines dosage, notably the interleukin 1β (IL-1β), interleukin 6 (IL-6) and the Tumor Necrosis Factor α (TNF-α) immunodosage. Results Twenty-four patients were included in this study, aged between four and ten years old (mean age= 6,55 years; minimum=4; maximum=10 years). Our sample was mainly represented by male patients (95,6%). TNF-α plasmatic levels were high (>5pg/mL) among all of our sample with a mean of 11,6 pg/mL (minimum= 6,87; maximum=17,7 pg/mL; standard deviation= 3,52 pg/mL), suggesting abnormal peripheral blood mononuclear cells response. However, IL-1β and IL-6 plasmatic levels were relatively normal. Conclusions An immune response dysregulation was detected in our sample. Multiple clinical and experimental studies investigated the implication of inflammatory cytokines in neurodevelopmental disruption. Their results, however, remain controversial and limited by small samples. Further studies need to be done in order to investigate the neuroimmunological factors linked with ASD. https://www.cambridge.org/core/product/identifier/S092493382100571X/type/journal_articleautism spectrum disorderneurodevelopmentneuroinflammationinflammatory cytokines |
| spellingShingle | A. Ben Othman H. Slama E. Cherif M. Azaiez H. Gharsallah Inflammatory cytokines dysfunction in autism spectrum disorder European Psychiatry autism spectrum disorder neurodevelopment neuroinflammation inflammatory cytokines |
| title | Inflammatory cytokines dysfunction in autism spectrum disorder |
| title_full | Inflammatory cytokines dysfunction in autism spectrum disorder |
| title_fullStr | Inflammatory cytokines dysfunction in autism spectrum disorder |
| title_full_unstemmed | Inflammatory cytokines dysfunction in autism spectrum disorder |
| title_short | Inflammatory cytokines dysfunction in autism spectrum disorder |
| title_sort | inflammatory cytokines dysfunction in autism spectrum disorder |
| topic | autism spectrum disorder neurodevelopment neuroinflammation inflammatory cytokines |
| url | https://www.cambridge.org/core/product/identifier/S092493382100571X/type/journal_article |
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