Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells
Abstract Human pluripotent embryonic stem cells have two special features: self-renewal and pluripotency. It is important to understand the properties of pluripotent stem cells and reprogrammed stem cells. One of the major problems is the risk of reprogrammed stem cells developing into tumors. To un...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13046-020-01584-0 |
| _version_ | 1811328550768214016 |
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| author | Kenly Wuputra Chia-Chen Ku Deng-Chyang Wu Ying-Chu Lin Shigeo Saito Kazunari K. Yokoyama |
| author_facet | Kenly Wuputra Chia-Chen Ku Deng-Chyang Wu Ying-Chu Lin Shigeo Saito Kazunari K. Yokoyama |
| author_sort | Kenly Wuputra |
| collection | DOAJ |
| description | Abstract Human pluripotent embryonic stem cells have two special features: self-renewal and pluripotency. It is important to understand the properties of pluripotent stem cells and reprogrammed stem cells. One of the major problems is the risk of reprogrammed stem cells developing into tumors. To understand the process of differentiation through which stem cells develop into cancer cells, investigators have attempted to identify the key factors that generate tumors in humans. The most effective method for the prevention of tumorigenesis is the exclusion of cancer cells during cell reprogramming. The risk of cancer formation is dependent on mutations of oncogenes and tumor suppressor genes during the conversion of stem cells to cancer cells and on the environmental effects of pluripotent stem cells. Dissecting the processes of epigenetic regulation and chromatin regulation may be helpful for achieving correct cell reprogramming without inducing tumor formation and for developing new drugs for cancer treatment. This review focuses on the risk of tumor formation by human pluripotent stem cells, and on the possible treatment options if it occurs. Potential new techniques that target epigenetic processes and chromatin regulation provide opportunities for human cancer modeling and clinical applications of regenerative medicine. |
| first_indexed | 2024-04-13T15:28:15Z |
| format | Article |
| id | doaj.art-bbea83d8a3f846d884cf96409bb4ee49 |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-04-13T15:28:15Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-bbea83d8a3f846d884cf96409bb4ee492022-12-22T02:41:28ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662020-06-0139112410.1186/s13046-020-01584-0Prevention of tumor risk associated with the reprogramming of human pluripotent stem cellsKenly Wuputra0Chia-Chen Ku1Deng-Chyang Wu2Ying-Chu Lin3Shigeo Saito4Kazunari K. Yokoyama5Graduate Institute of Medicine, Kaohsiung Medical UniversityGraduate Institute of Medicine, Kaohsiung Medical UniversityRegenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University HospitalSchool of Dentistry, School of Medicine, Kaohsiung Medical UniversityWaseda University Research Institute for Science and EngineeringGraduate Institute of Medicine, Kaohsiung Medical UniversityAbstract Human pluripotent embryonic stem cells have two special features: self-renewal and pluripotency. It is important to understand the properties of pluripotent stem cells and reprogrammed stem cells. One of the major problems is the risk of reprogrammed stem cells developing into tumors. To understand the process of differentiation through which stem cells develop into cancer cells, investigators have attempted to identify the key factors that generate tumors in humans. The most effective method for the prevention of tumorigenesis is the exclusion of cancer cells during cell reprogramming. The risk of cancer formation is dependent on mutations of oncogenes and tumor suppressor genes during the conversion of stem cells to cancer cells and on the environmental effects of pluripotent stem cells. Dissecting the processes of epigenetic regulation and chromatin regulation may be helpful for achieving correct cell reprogramming without inducing tumor formation and for developing new drugs for cancer treatment. This review focuses on the risk of tumor formation by human pluripotent stem cells, and on the possible treatment options if it occurs. Potential new techniques that target epigenetic processes and chromatin regulation provide opportunities for human cancer modeling and clinical applications of regenerative medicine.http://link.springer.com/article/10.1186/s13046-020-01584-0Cancer riskCell reprogrammingPluripotent stem cellsRegenerative medicineTherapeutic agents |
| spellingShingle | Kenly Wuputra Chia-Chen Ku Deng-Chyang Wu Ying-Chu Lin Shigeo Saito Kazunari K. Yokoyama Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells Journal of Experimental & Clinical Cancer Research Cancer risk Cell reprogramming Pluripotent stem cells Regenerative medicine Therapeutic agents |
| title | Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells |
| title_full | Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells |
| title_fullStr | Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells |
| title_full_unstemmed | Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells |
| title_short | Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells |
| title_sort | prevention of tumor risk associated with the reprogramming of human pluripotent stem cells |
| topic | Cancer risk Cell reprogramming Pluripotent stem cells Regenerative medicine Therapeutic agents |
| url | http://link.springer.com/article/10.1186/s13046-020-01584-0 |
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