Genome-wide tiled detection of circulating Mycobacterium tuberculosis cell-free DNA using Cas13
In this work, the authors developed a multiplexed, minimally invasive, CRISPR-Cas13-based approach to detect Mycobacterium tuberculosis cell-free DNA in the plasma of active pulmonary tuberculosis patients.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37183-8 |
| _version_ | 1797853741607550976 |
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| author | Sri Gowtham Thakku Jackson Lirette Kanagavel Murugesan Julie Chen Grant Theron Niaz Banaei Paul C. Blainey James Gomez Sharon Y. Wong Deborah T. Hung |
| author_facet | Sri Gowtham Thakku Jackson Lirette Kanagavel Murugesan Julie Chen Grant Theron Niaz Banaei Paul C. Blainey James Gomez Sharon Y. Wong Deborah T. Hung |
| author_sort | Sri Gowtham Thakku |
| collection | DOAJ |
| description | In this work, the authors developed a multiplexed, minimally invasive, CRISPR-Cas13-based approach to detect Mycobacterium tuberculosis cell-free DNA in the plasma of active pulmonary tuberculosis patients. |
| first_indexed | 2024-04-09T19:54:30Z |
| format | Article |
| id | doaj.art-bbeaeafe49934ce4acd3e1fecb9b7f87 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T19:54:30Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-bbeaeafe49934ce4acd3e1fecb9b7f872023-04-03T05:32:53ZengNature PortfolioNature Communications2041-17232023-03-0114111310.1038/s41467-023-37183-8Genome-wide tiled detection of circulating Mycobacterium tuberculosis cell-free DNA using Cas13Sri Gowtham Thakku0Jackson Lirette1Kanagavel Murugesan2Julie Chen3Grant Theron4Niaz Banaei5Paul C. Blainey6James Gomez7Sharon Y. Wong8Deborah T. Hung9Broad Institute of MIT and HarvardBroad Institute of MIT and HarvardDepartment of Pathology, Stanford University School of MedicineBroad Institute of MIT and HarvardDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research and SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch UniversityDepartment of Pathology, Stanford University School of MedicineBroad Institute of MIT and HarvardBroad Institute of MIT and HarvardBroad Institute of MIT and HarvardBroad Institute of MIT and HarvardIn this work, the authors developed a multiplexed, minimally invasive, CRISPR-Cas13-based approach to detect Mycobacterium tuberculosis cell-free DNA in the plasma of active pulmonary tuberculosis patients.https://doi.org/10.1038/s41467-023-37183-8 |
| spellingShingle | Sri Gowtham Thakku Jackson Lirette Kanagavel Murugesan Julie Chen Grant Theron Niaz Banaei Paul C. Blainey James Gomez Sharon Y. Wong Deborah T. Hung Genome-wide tiled detection of circulating Mycobacterium tuberculosis cell-free DNA using Cas13 Nature Communications |
| title | Genome-wide tiled detection of circulating Mycobacterium tuberculosis cell-free DNA using Cas13 |
| title_full | Genome-wide tiled detection of circulating Mycobacterium tuberculosis cell-free DNA using Cas13 |
| title_fullStr | Genome-wide tiled detection of circulating Mycobacterium tuberculosis cell-free DNA using Cas13 |
| title_full_unstemmed | Genome-wide tiled detection of circulating Mycobacterium tuberculosis cell-free DNA using Cas13 |
| title_short | Genome-wide tiled detection of circulating Mycobacterium tuberculosis cell-free DNA using Cas13 |
| title_sort | genome wide tiled detection of circulating mycobacterium tuberculosis cell free dna using cas13 |
| url | https://doi.org/10.1038/s41467-023-37183-8 |
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