Multiomics analysis reveals the mechanical stress-dependent changes in trabecular meshwork cytoskeletal-extracellular matrix interactions

Multiomics analysis reveals the mechanical stress-dependent changes in trabecular meshwork cytoskeletal-extracellular matrix interactions

Trabecular meshwork (TM) tissue is subjected to constant mechanical stress due to the ocular pulse created by the cardiac cycle. This brings about alterations in the membrane lipids and associated cell–cell adhesion and cell–extracellular matrix (ECM) interactions, triggering intracellular signaling...

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Bibliographic Details
Main Authors: Avinash Soundararajan, Ting Wang, Rekha Sundararajan, Aruna Wijeratne, Amber Mosley, Faith Christine Harvey, Sanjoy Bhattacharya, Padmanabhan Paranji Pattabiraman
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
trabecular meshwork (TM)
glaucoma
ocular hypertension
mechanical stretch
multiomics analysis
cytoskeleton
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.874828/full

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