A 7-year study on the prevalence of congenital hypothyroidism in northern Iran
Background: Congenital hypothyroidism (CH) is one of the most common congenital endocrine disorders. The present study determined the prevalence and demographic characteristics of congenital hypothyroidism in the north of Iran. Objective: To determine the prevalence of congenital hypothyroidism b...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Electronic Physician
2018-04-01
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| Series: | Electronic Physician |
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984024/ |
| _version_ | 1819043816991096832 |
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| author | Zahra Beheshti Rozita Rezaei Abbas Alipour Mehrnoosh Kosarian Sussan Saatsaz |
| author_facet | Zahra Beheshti Rozita Rezaei Abbas Alipour Mehrnoosh Kosarian Sussan Saatsaz |
| author_sort | Zahra Beheshti |
| collection | DOAJ |
| description | Background: Congenital hypothyroidism (CH) is one of the most common congenital endocrine disorders.
The present study determined the prevalence and demographic characteristics of congenital hypothyroidism in the
north of Iran.
Objective: To determine the prevalence of congenital hypothyroidism based on transient and permanent types
with demographic characteristics in Mazandaran province in northern Iran.
Methods: This retrospective descriptive survey analyzed the medical records of children with primary diagnosis
of CH in health centers in all cities of Mazandaran Province between June 2009 and March 2016. To compare the
study groups (CH type) in terms of quantitative and qualitative variables, the t-test and Chi-square test were used,
respectively using the SPSS22. P-value <0.05 was considered as significant.
Results: Of 269,088 infants screened during the study period, 548 infants with primary congenital
hypothyroidism were identified (a prevalence of 1 per 491 births) and congenital hypothyroidism was definitively
diagnosed in 389 children (a prevalence of 1 per 453 births); of them, 169 had permanent CH (a prevalence of 1
per 1043 births) and 220 had transient CH (a prevalence of 1 per 801 births). The female to male ratio in the
permanent congenital hypothyroidism group was higher than that in the transient congenital hypothyroidism
group (p=0.08). The family relationship between mother and father was stronger in the permanent congenital
hypothyroidism group than in the transient congenital hypothyroidism group (p=0.03).
Conclusion: These findings show that congenital hypothyroidism is more prevalent in the north of Iran than in
other areas of Iran; the prevalence of transient CH is particularly higher than permanent CH. |
| first_indexed | 2024-12-21T10:02:48Z |
| format | Article |
| id | doaj.art-bbec168f4efd45daab255d41ffd021db |
| institution | Directory Open Access Journal |
| issn | 2008-5842 2008-5842 |
| language | English |
| last_indexed | 2024-12-21T10:02:48Z |
| publishDate | 2018-04-01 |
| publisher | Electronic Physician |
| record_format | Article |
| series | Electronic Physician |
| spelling | doaj.art-bbec168f4efd45daab255d41ffd021db2022-12-21T19:07:55ZengElectronic PhysicianElectronic Physician2008-58422008-58422018-04-011046689669610.19082/6689A 7-year study on the prevalence of congenital hypothyroidism in northern IranZahra BeheshtiRozita RezaeiAbbas AlipourMehrnoosh KosarianSussan SaatsazBackground: Congenital hypothyroidism (CH) is one of the most common congenital endocrine disorders. The present study determined the prevalence and demographic characteristics of congenital hypothyroidism in the north of Iran. Objective: To determine the prevalence of congenital hypothyroidism based on transient and permanent types with demographic characteristics in Mazandaran province in northern Iran. Methods: This retrospective descriptive survey analyzed the medical records of children with primary diagnosis of CH in health centers in all cities of Mazandaran Province between June 2009 and March 2016. To compare the study groups (CH type) in terms of quantitative and qualitative variables, the t-test and Chi-square test were used, respectively using the SPSS22. P-value <0.05 was considered as significant. Results: Of 269,088 infants screened during the study period, 548 infants with primary congenital hypothyroidism were identified (a prevalence of 1 per 491 births) and congenital hypothyroidism was definitively diagnosed in 389 children (a prevalence of 1 per 453 births); of them, 169 had permanent CH (a prevalence of 1 per 1043 births) and 220 had transient CH (a prevalence of 1 per 801 births). The female to male ratio in the permanent congenital hypothyroidism group was higher than that in the transient congenital hypothyroidism group (p=0.08). The family relationship between mother and father was stronger in the permanent congenital hypothyroidism group than in the transient congenital hypothyroidism group (p=0.03). Conclusion: These findings show that congenital hypothyroidism is more prevalent in the north of Iran than in other areas of Iran; the prevalence of transient CH is particularly higher than permanent CH.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984024/Neonate screeningCongenital hypothyroidismPermanent |
| spellingShingle | Zahra Beheshti Rozita Rezaei Abbas Alipour Mehrnoosh Kosarian Sussan Saatsaz A 7-year study on the prevalence of congenital hypothyroidism in northern Iran Electronic Physician Neonate screening Congenital hypothyroidism Permanent |
| title | A 7-year study on the prevalence of congenital hypothyroidism in northern Iran |
| title_full | A 7-year study on the prevalence of congenital hypothyroidism in northern Iran |
| title_fullStr | A 7-year study on the prevalence of congenital hypothyroidism in northern Iran |
| title_full_unstemmed | A 7-year study on the prevalence of congenital hypothyroidism in northern Iran |
| title_short | A 7-year study on the prevalence of congenital hypothyroidism in northern Iran |
| title_sort | 7 year study on the prevalence of congenital hypothyroidism in northern iran |
| topic | Neonate screening Congenital hypothyroidism Permanent |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984024/ |
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