Platycodin D induces apoptosis via regulating MAPK pathway and promotes autophagy in colon cancer cell

Platycodin D induces apoptosis via regulating MAPK pathway and promotes autophagy in colon cancer cell

Platycodin D (PD) is the main component of triterpene saponins found in Platycodi radix. In this study, we observed a decrease in cell viability, an increase in apoptotic bodies, and an increase in the rate of apoptosis. Also, we observed an increase in cleaved PARP and Bax, a decrease in Bcl-2, and...

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Bibliographic Details
Main Authors: So-Hee Han, Jae-Han Lee, Joong-Seok Woo, Gi-Hwan Jung, Soo-Hyun Jung, Eun-Ji Han, Young-Seok Park, Byeong-Soo Kim, Sang-Ki Kim, Byung-Kwon Park, Ji-Youn Jung
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Platycodin D
Colon cancer
Apoptosis
Autophagy
MAPK pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224000970

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