Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling
WNT/β-catenin signaling is a highly complex pathway that plays diverse roles in various cellular processes. While WNT ligands usually signal through their dedicated Frizzled receptors, the decision to signal in a β-catenin-dependent or -independent manner rests upon the type of co-receptors used. Ca...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-03-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.858782/full |
| _version_ | 1819123818978869248 |
|---|---|
| author | Kinjal Shah Kinjal Shah Julhash U. Kazi Julhash U. Kazi |
| author_facet | Kinjal Shah Kinjal Shah Julhash U. Kazi Julhash U. Kazi |
| author_sort | Kinjal Shah |
| collection | DOAJ |
| description | WNT/β-catenin signaling is a highly complex pathway that plays diverse roles in various cellular processes. While WNT ligands usually signal through their dedicated Frizzled receptors, the decision to signal in a β-catenin-dependent or -independent manner rests upon the type of co-receptors used. Canonical WNT signaling is β-catenin-dependent, whereas non-canonical WNT signaling is β-catenin-independent according to the classical definition. This still holds true, albeit with some added complexity, as both the pathways seem to cross-talk with intertwined networks that involve the use of different ligands, receptors, and co-receptors. β-catenin can be directly phosphorylated by various kinases governing its participation in either canonical or non-canonical pathways. Moreover, the co-activators that associate with β-catenin determine the output of the pathway in terms of induction of genes promoting proliferation or differentiation. In this review, we provide an overview of how protein phosphorylation controls WNT/β-catenin signaling, particularly in human cancer. |
| first_indexed | 2024-12-22T07:14:24Z |
| format | Article |
| id | doaj.art-bbecada698fa440889498f20cadab852 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-22T07:14:24Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-bbecada698fa440889498f20cadab8522022-12-21T18:34:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-03-011210.3389/fonc.2022.858782858782Phosphorylation-Dependent Regulation of WNT/Beta-Catenin SignalingKinjal Shah0Kinjal Shah1Julhash U. Kazi2Julhash U. Kazi3Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund, SwedenLund Stem Cell Center, Department of Laboratory Medicine, Lund University, Lund, SwedenDivision of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund, SwedenLund Stem Cell Center, Department of Laboratory Medicine, Lund University, Lund, SwedenWNT/β-catenin signaling is a highly complex pathway that plays diverse roles in various cellular processes. While WNT ligands usually signal through their dedicated Frizzled receptors, the decision to signal in a β-catenin-dependent or -independent manner rests upon the type of co-receptors used. Canonical WNT signaling is β-catenin-dependent, whereas non-canonical WNT signaling is β-catenin-independent according to the classical definition. This still holds true, albeit with some added complexity, as both the pathways seem to cross-talk with intertwined networks that involve the use of different ligands, receptors, and co-receptors. β-catenin can be directly phosphorylated by various kinases governing its participation in either canonical or non-canonical pathways. Moreover, the co-activators that associate with β-catenin determine the output of the pathway in terms of induction of genes promoting proliferation or differentiation. In this review, we provide an overview of how protein phosphorylation controls WNT/β-catenin signaling, particularly in human cancer.https://www.frontiersin.org/articles/10.3389/fonc.2022.858782/fullβ-cateninCTNNB1GSK3βadherens junctionsAXINCK1 |
| spellingShingle | Kinjal Shah Kinjal Shah Julhash U. Kazi Julhash U. Kazi Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling Frontiers in Oncology β-catenin CTNNB1 GSK3β adherens junctions AXIN CK1 |
| title | Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling |
| title_full | Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling |
| title_fullStr | Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling |
| title_full_unstemmed | Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling |
| title_short | Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling |
| title_sort | phosphorylation dependent regulation of wnt beta catenin signaling |
| topic | β-catenin CTNNB1 GSK3β adherens junctions AXIN CK1 |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.858782/full |
| work_keys_str_mv | AT kinjalshah phosphorylationdependentregulationofwntbetacateninsignaling AT kinjalshah phosphorylationdependentregulationofwntbetacateninsignaling AT julhashukazi phosphorylationdependentregulationofwntbetacateninsignaling AT julhashukazi phosphorylationdependentregulationofwntbetacateninsignaling |