Spatial multiomic profiling reveals the novel polarization of foamy macrophages within necrotic granulomatous lesions developed in lungs of C3HeB/FeJ mice infected with Mycobacterium tuberculosis

Spatial multiomic profiling reveals the novel polarization of foamy macrophages within necrotic granulomatous lesions developed in lungs of C3HeB/FeJ mice infected with Mycobacterium tuberculosis

Infection with Mycobacterium tuberculosis leads to the development of tuberculosis (TB) with the formation of granulomatous lesions. Foamy macrophages (FM) are a hallmark of TB granulomas, because they provide the primary platform of M. tuberculosis proliferation and the main source of caseous necro...

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Bibliographic Details
Main Authors: Shintaro Seto, Hajime Nakamura, Tz-Chun Guo, Haruka Hikichi, Keiko Wakabayashi, Akiko Miyabayashi, Toshi Nagata, Minako Hijikata, Naoto Keicho
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Tuberculosis
Mycobacterium tuberculosis
C3HeB/FeJ
necrotic granuloma
foamy macrophage
proteomics
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.968543/full

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