Silica-Lipid Hybrid Microparticles as Efficient Vehicles for Enhanced Stability and Bioaccessibility of Curcumin
Curcumin is an active ingredient with multiple functions, but its application is often restricted due to its poor water solubility, weak stability, and consequently low bioaccessibility. Based on this, the aim of this work is to develop a new vehicle to overcome these restrictions. Here we developed...
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| Format: | Article |
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University of Zagreb Faculty of Food Technology and Biotechnology
2019-01-01
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| Series: | Food Technology and Biotechnology |
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| Online Access: | https://hrcak.srce.hr/file/330967 |
| _version_ | 1797207366536527872 |
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| author | Yudi Ma Qiang Wang Dantong Wang Juan Huang Rui Sun Xinyu Mao Yuan Tian Qiang Xia |
| author_facet | Yudi Ma Qiang Wang Dantong Wang Juan Huang Rui Sun Xinyu Mao Yuan Tian Qiang Xia |
| author_sort | Yudi Ma |
| collection | DOAJ |
| description | Curcumin is an active ingredient with multiple functions, but its application is often restricted due to its poor water solubility, weak stability, and consequently low bioaccessibility. Based on this, the aim of this work is to develop a new vehicle to overcome these restrictions. Here we developed a curcumin-loaded nanoemulsion and then curcumin-loaded silica-lipid hybrid microparticles through emulsification and vacuum drying, respectively. The loading of curcumin in the nanoemulsion and microparticles was (0.30±0.02) and (0.67±0.02) %, respectively. FTIR and XRD analyses of microparticles revealed that curcumin was encapsulated in porous, amorphous silica. In vitro antioxidant activities showed that the encapsulation would not affect the antioxidant activity of curcumin. In vitro simulated digestion indicated that nanoemulsion and microparticles had higher curcumin bioaccessibility than the control group. The storage stability of microparticles remained the same during 6 weeks in the dark at 4, 25 and 40 °C. Moreover, the microparticles had a better chemical stability than nanoemulsion under the light. The cell viability was over 80 % when the concentration of nanocarriers was less than 45 μg/mL. Hence, the microparticles could be a promising means to load curcumin and improve its solubility, light stability and bioaccessibility
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| first_indexed | 2024-04-24T09:21:46Z |
| format | Article |
| id | doaj.art-bbeceaee1cb64d61a7a6967f4949d6d7 |
| institution | Directory Open Access Journal |
| issn | 1330-9862 1334-2606 |
| language | English |
| last_indexed | 2024-04-24T09:21:46Z |
| publishDate | 2019-01-01 |
| publisher | University of Zagreb Faculty of Food Technology and Biotechnology |
| record_format | Article |
| series | Food Technology and Biotechnology |
| spelling | doaj.art-bbeceaee1cb64d61a7a6967f4949d6d72024-04-15T15:48:33ZengUniversity of Zagreb Faculty of Food Technology and BiotechnologyFood Technology and Biotechnology1330-98621334-26062019-01-0157331933010.17113/ftb.57.03.19.6035Silica-Lipid Hybrid Microparticles as Efficient Vehicles for Enhanced Stability and Bioaccessibility of Curcumin Yudi Ma0Qiang Wang1Dantong Wang2Juan Huang3Rui Sun4Xinyu Mao5Yuan Tian6Qiang Xia7Collaborative Innovation Center of Suzhou Nano Science and Technology, No. 150 Renai Road 215123 Suzhou, PR ChinaCollaborative Innovation Center of Suzhou Nano Science and Technology, No. 150 Renai Road 215123 Suzhou, PR ChinaCollaborative Innovation Center of Suzhou Nano Science and Technology, No. 150 Renai Road 215123 Suzhou, PR ChinaCollaborative Innovation Center of Suzhou Nano Science and Technology, No. 150 Renai Road 215123 Suzhou, PR ChinaNational Demonstration Center for Experimental Biomedical Engineering Education, Southeast University, No. 2, Sipailou Street, 210096 Nanjing, PR ChinaNational Demonstration Center for Experimental Biomedical Engineering Education, Southeast University, No. 2, Sipailou Street, 210096 Nanjing, PR ChinaNational Demonstration Center for Experimental Biomedical Engineering Education, Southeast University, No. 2, Sipailou Street, 210096 Nanjing, PR ChinaCollaborative Innovation Center of Suzhou Nano Science and Technology, No. 150 Renai Road 215123 Suzhou, PR ChinaCurcumin is an active ingredient with multiple functions, but its application is often restricted due to its poor water solubility, weak stability, and consequently low bioaccessibility. Based on this, the aim of this work is to develop a new vehicle to overcome these restrictions. Here we developed a curcumin-loaded nanoemulsion and then curcumin-loaded silica-lipid hybrid microparticles through emulsification and vacuum drying, respectively. The loading of curcumin in the nanoemulsion and microparticles was (0.30±0.02) and (0.67±0.02) %, respectively. FTIR and XRD analyses of microparticles revealed that curcumin was encapsulated in porous, amorphous silica. In vitro antioxidant activities showed that the encapsulation would not affect the antioxidant activity of curcumin. In vitro simulated digestion indicated that nanoemulsion and microparticles had higher curcumin bioaccessibility than the control group. The storage stability of microparticles remained the same during 6 weeks in the dark at 4, 25 and 40 °C. Moreover, the microparticles had a better chemical stability than nanoemulsion under the light. The cell viability was over 80 % when the concentration of nanocarriers was less than 45 μg/mL. Hence, the microparticles could be a promising means to load curcumin and improve its solubility, light stability and bioaccessibility https://hrcak.srce.hr/file/330967curcuminsilica-lipid hybrid microparticlesantioxidant activitybioaccessibilitystorage stability |
| spellingShingle | Yudi Ma Qiang Wang Dantong Wang Juan Huang Rui Sun Xinyu Mao Yuan Tian Qiang Xia Silica-Lipid Hybrid Microparticles as Efficient Vehicles for Enhanced Stability and Bioaccessibility of Curcumin Food Technology and Biotechnology curcumin silica-lipid hybrid microparticles antioxidant activity bioaccessibility storage stability |
| title | Silica-Lipid Hybrid Microparticles as Efficient Vehicles for Enhanced Stability and Bioaccessibility of Curcumin
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| title_full | Silica-Lipid Hybrid Microparticles as Efficient Vehicles for Enhanced Stability and Bioaccessibility of Curcumin
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| title_fullStr | Silica-Lipid Hybrid Microparticles as Efficient Vehicles for Enhanced Stability and Bioaccessibility of Curcumin
|
| title_full_unstemmed | Silica-Lipid Hybrid Microparticles as Efficient Vehicles for Enhanced Stability and Bioaccessibility of Curcumin
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| title_short | Silica-Lipid Hybrid Microparticles as Efficient Vehicles for Enhanced Stability and Bioaccessibility of Curcumin
|
| title_sort | silica lipid hybrid microparticles as efficient vehicles for enhanced stability and bioaccessibility of curcumin |
| topic | curcumin silica-lipid hybrid microparticles antioxidant activity bioaccessibility storage stability |
| url | https://hrcak.srce.hr/file/330967 |
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