Nano Ultrasound Contrast Agent for Synergistic Chemo‐photothermal Therapy and Enhanced Immunotherapy Against Liver Cancer and Metastasis
Abstract Advanced liver cancer is the most fatal malignant cancer, and the clinical outcomes of treatment are not very satisfactory due to the complexity and heterogeneity of the tumor. Combination therapy can efficiently enhance tumor treatment by stimulating multiple pathways and regulating the tu...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202300878 |
| _version_ | 1827891512746180608 |
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| author | Yijie Qiu Zhihua Wu Yanling Chen Jinghan Liao Qi Zhang Quan Wang Yi Duan Ke Gong Sheng Chen Liting Wang Peili Fan Yourong Duan Wenping Wang Yi Dong |
| author_facet | Yijie Qiu Zhihua Wu Yanling Chen Jinghan Liao Qi Zhang Quan Wang Yi Duan Ke Gong Sheng Chen Liting Wang Peili Fan Yourong Duan Wenping Wang Yi Dong |
| author_sort | Yijie Qiu |
| collection | DOAJ |
| description | Abstract Advanced liver cancer is the most fatal malignant cancer, and the clinical outcomes of treatment are not very satisfactory due to the complexity and heterogeneity of the tumor. Combination therapy can efficiently enhance tumor treatment by stimulating multiple pathways and regulating the tumor immune microenvironment. Nanodrug delivery systems have become attractive candidates for combined strategies for liver cancer treatment. This study reports a nano ultrasound contrast agent (arsenic trioxide (ATO)/PFH NPs@Au‐cRGD) to integrate diagnosis and treatment for efficient ultrasound imaging and liver cancer therapy. This nanodrug delivery system promotes tumor‐associated antigens release through ATO‐induced ferroptosis and photothermal‐induced immunogenic cell death, enhancing the synergistic effects of ATO and photothermal therapy in human Huh7 and mouse Hepa1–6 cells. This drug delivery system successfully activates the antitumor immune response and promotes macrophage M1 polarization in tumor microenvironment with low side effects in subcutaneous and orthotopic liver cancer. Furthermore, tumor metastasis is inhibited and long‐term immunological memory is also established in orthotopic liver cancer when the nanodrug delivery system is combined with anti‐programmed death‐ligand 1 (PD‐L1) immunotherapy. This safe nanodrug delivery system can enhance antitumor therapy, inhibit lung metastasis, and achieve visual assessment of therapeutic efficacy, providing substantial potential in clinic applications for liver cancer. |
| first_indexed | 2024-03-12T21:26:54Z |
| format | Article |
| id | doaj.art-bbee0238800145688da7721c52f8e1fe |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-12T21:26:54Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-bbee0238800145688da7721c52f8e1fe2023-07-28T06:53:00ZengWileyAdvanced Science2198-38442023-07-011021n/an/a10.1002/advs.202300878Nano Ultrasound Contrast Agent for Synergistic Chemo‐photothermal Therapy and Enhanced Immunotherapy Against Liver Cancer and MetastasisYijie Qiu0Zhihua Wu1Yanling Chen2Jinghan Liao3Qi Zhang4Quan Wang5Yi Duan6Ke Gong7Sheng Chen8Liting Wang9Peili Fan10Yourong Duan11Wenping Wang12Yi Dong13Department of Ultrasound Zhongshan Hospital Fudan University 180th Fenglin Road Shanghai 200032 ChinaState Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital School of Medicine Shanghai Jiao Tong University 2200/25 Xietu Rd Shanghai 200032 ChinaDepartment of Ultrasound Zhongshan Hospital Fudan University 180th Fenglin Road Shanghai 200032 ChinaState Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital School of Medicine Shanghai Jiao Tong University 2200/25 Xietu Rd Shanghai 200032 ChinaDepartment of Ultrasound Zhongshan Hospital Fudan University 180th Fenglin Road Shanghai 200032 ChinaState Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital School of Medicine Shanghai Jiao Tong University 2200/25 Xietu Rd Shanghai 200032 ChinaState Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital School of Medicine Shanghai Jiao Tong University 2200/25 Xietu Rd Shanghai 200032 ChinaState Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital School of Medicine Shanghai Jiao Tong University 2200/25 Xietu Rd Shanghai 200032 ChinaDepartment of Ultrasound Zhongshan Hospital Fudan University 180th Fenglin Road Shanghai 200032 ChinaState Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital School of Medicine Shanghai Jiao Tong University 2200/25 Xietu Rd Shanghai 200032 ChinaDepartment of Ultrasound Zhongshan Hospital Fudan University 180th Fenglin Road Shanghai 200032 ChinaState Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital School of Medicine Shanghai Jiao Tong University 2200/25 Xietu Rd Shanghai 200032 ChinaDepartment of Ultrasound Zhongshan Hospital Fudan University 180th Fenglin Road Shanghai 200032 ChinaDepartment of Ultrasound Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine 1665 Kongjiang Road Shanghai 200092 ChinaAbstract Advanced liver cancer is the most fatal malignant cancer, and the clinical outcomes of treatment are not very satisfactory due to the complexity and heterogeneity of the tumor. Combination therapy can efficiently enhance tumor treatment by stimulating multiple pathways and regulating the tumor immune microenvironment. Nanodrug delivery systems have become attractive candidates for combined strategies for liver cancer treatment. This study reports a nano ultrasound contrast agent (arsenic trioxide (ATO)/PFH NPs@Au‐cRGD) to integrate diagnosis and treatment for efficient ultrasound imaging and liver cancer therapy. This nanodrug delivery system promotes tumor‐associated antigens release through ATO‐induced ferroptosis and photothermal‐induced immunogenic cell death, enhancing the synergistic effects of ATO and photothermal therapy in human Huh7 and mouse Hepa1–6 cells. This drug delivery system successfully activates the antitumor immune response and promotes macrophage M1 polarization in tumor microenvironment with low side effects in subcutaneous and orthotopic liver cancer. Furthermore, tumor metastasis is inhibited and long‐term immunological memory is also established in orthotopic liver cancer when the nanodrug delivery system is combined with anti‐programmed death‐ligand 1 (PD‐L1) immunotherapy. This safe nanodrug delivery system can enhance antitumor therapy, inhibit lung metastasis, and achieve visual assessment of therapeutic efficacy, providing substantial potential in clinic applications for liver cancer.https://doi.org/10.1002/advs.202300878arsenic trioxideferroptosisimmunotherapynano ultrasound contrast agentphotothermal therapy |
| spellingShingle | Yijie Qiu Zhihua Wu Yanling Chen Jinghan Liao Qi Zhang Quan Wang Yi Duan Ke Gong Sheng Chen Liting Wang Peili Fan Yourong Duan Wenping Wang Yi Dong Nano Ultrasound Contrast Agent for Synergistic Chemo‐photothermal Therapy and Enhanced Immunotherapy Against Liver Cancer and Metastasis Advanced Science arsenic trioxide ferroptosis immunotherapy nano ultrasound contrast agent photothermal therapy |
| title | Nano Ultrasound Contrast Agent for Synergistic Chemo‐photothermal Therapy and Enhanced Immunotherapy Against Liver Cancer and Metastasis |
| title_full | Nano Ultrasound Contrast Agent for Synergistic Chemo‐photothermal Therapy and Enhanced Immunotherapy Against Liver Cancer and Metastasis |
| title_fullStr | Nano Ultrasound Contrast Agent for Synergistic Chemo‐photothermal Therapy and Enhanced Immunotherapy Against Liver Cancer and Metastasis |
| title_full_unstemmed | Nano Ultrasound Contrast Agent for Synergistic Chemo‐photothermal Therapy and Enhanced Immunotherapy Against Liver Cancer and Metastasis |
| title_short | Nano Ultrasound Contrast Agent for Synergistic Chemo‐photothermal Therapy and Enhanced Immunotherapy Against Liver Cancer and Metastasis |
| title_sort | nano ultrasound contrast agent for synergistic chemo photothermal therapy and enhanced immunotherapy against liver cancer and metastasis |
| topic | arsenic trioxide ferroptosis immunotherapy nano ultrasound contrast agent photothermal therapy |
| url | https://doi.org/10.1002/advs.202300878 |
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