Dual functions of Insig proteins in cholesterol homeostasis
<p>Abstract</p> <p>The molecular mechanism of how cells maintain cholesterol homeostasis has become clearer for the understanding of complicated association between sterol regulatory element-binding proteins (SREBPs), SREBP cleavage-activating protein (SCAP), 3-hydroxy-3-methylglut...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-12-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://www.lipidworld.com/content/11/1/173 |
| _version_ | 1819089129886973952 |
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| author | Dong Xiao-Ying Tang Sheng-Qiu Chen Jin-Ding |
| author_facet | Dong Xiao-Ying Tang Sheng-Qiu Chen Jin-Ding |
| author_sort | Dong Xiao-Ying |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The molecular mechanism of how cells maintain cholesterol homeostasis has become clearer for the understanding of complicated association between sterol regulatory element-binding proteins (SREBPs), SREBP cleavage-activating protein (SCAP), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) and Insuin induced-genes (Insigs). The pioneering researches suggested that SREBP activated the transcription of genes encoding HMG-CoA reductase and all of the other enzymes involved in the synthesis of cholesterol and lipids. However, SREBPs can not exert their activities alone, they must form a complex with another protein, SCAP in the endoplasmic reticulum (ER) and translocate to Golgi. Insigs are sensors and mediators that regulate cholesterol homeostasis through binding to SCAP and HMG-CoA reductase in diverse tissues such as adipose tissue and liver, as well as the cultured cells. In this article, we aim to review on the dual functions of Insig protein family in cholesterol homeostasis.</p> |
| first_indexed | 2024-12-21T22:03:02Z |
| format | Article |
| id | doaj.art-bbee8825c2b141899eee7e92ef4253bf |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-21T22:03:02Z |
| publishDate | 2012-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-bbee8825c2b141899eee7e92ef4253bf2022-12-21T18:48:46ZengBMCLipids in Health and Disease1476-511X2012-12-0111117310.1186/1476-511X-11-173Dual functions of Insig proteins in cholesterol homeostasisDong Xiao-YingTang Sheng-QiuChen Jin-Ding<p>Abstract</p> <p>The molecular mechanism of how cells maintain cholesterol homeostasis has become clearer for the understanding of complicated association between sterol regulatory element-binding proteins (SREBPs), SREBP cleavage-activating protein (SCAP), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) and Insuin induced-genes (Insigs). The pioneering researches suggested that SREBP activated the transcription of genes encoding HMG-CoA reductase and all of the other enzymes involved in the synthesis of cholesterol and lipids. However, SREBPs can not exert their activities alone, they must form a complex with another protein, SCAP in the endoplasmic reticulum (ER) and translocate to Golgi. Insigs are sensors and mediators that regulate cholesterol homeostasis through binding to SCAP and HMG-CoA reductase in diverse tissues such as adipose tissue and liver, as well as the cultured cells. In this article, we aim to review on the dual functions of Insig protein family in cholesterol homeostasis.</p>http://www.lipidworld.com/content/11/1/173Cholesterol homeostasisHMG-CoA reductaseInsigsMechanismSCAPSREBP |
| spellingShingle | Dong Xiao-Ying Tang Sheng-Qiu Chen Jin-Ding Dual functions of Insig proteins in cholesterol homeostasis Lipids in Health and Disease Cholesterol homeostasis HMG-CoA reductase Insigs Mechanism SCAP SREBP |
| title | Dual functions of Insig proteins in cholesterol homeostasis |
| title_full | Dual functions of Insig proteins in cholesterol homeostasis |
| title_fullStr | Dual functions of Insig proteins in cholesterol homeostasis |
| title_full_unstemmed | Dual functions of Insig proteins in cholesterol homeostasis |
| title_short | Dual functions of Insig proteins in cholesterol homeostasis |
| title_sort | dual functions of insig proteins in cholesterol homeostasis |
| topic | Cholesterol homeostasis HMG-CoA reductase Insigs Mechanism SCAP SREBP |
| url | http://www.lipidworld.com/content/11/1/173 |
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