Aberrant Modulations of Neurocognitive Network Dynamics in Migraine Comorbid With Tinnitus
PurposeThe possible relationship between migraine and tinnitus still remains elusive although migraine is often accompanied by chronic tinnitus. Several neuroimaging studies have reinforced the cognitive network abnormality in migraine and probably as well as tinnitus. The present work aims to inves...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.913191/full |
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| author | Liping Lan Yin Liu Jin-Jing Xu Di Ma Xindao Yin Yuanqing Wu Yu-Chen Chen Yuexin Cai |
| author_facet | Liping Lan Yin Liu Jin-Jing Xu Di Ma Xindao Yin Yuanqing Wu Yu-Chen Chen Yuexin Cai |
| author_sort | Liping Lan |
| collection | DOAJ |
| description | PurposeThe possible relationship between migraine and tinnitus still remains elusive although migraine is often accompanied by chronic tinnitus. Several neuroimaging studies have reinforced the cognitive network abnormality in migraine and probably as well as tinnitus. The present work aims to investigate the dynamic neurocognitive network alterations of migraine comorbid with tinnitus.Materials and MethodsParticipants included migraine patients (n = 32), tinnitus patients (n = 20), migraine with tinnitus (n = 27), and healthy controls (n = 47), matched for age and gender. Resting-state functional magnetic resonance imaging (rs-fMRI) with independent component analysis (ICA), sliding window cross-correlation, and clustering state analysis was used to detect the dynamic functional network connectivity (dFNC) of each group. Correlation analyses illustrated the association between clinical symptoms and abnormal dFNC in migraine as well as tinnitus.ResultsCompared with healthy controls, migraine patients exhibited decreased cerebellar network and visual network (CN-VN) connectivity in State 2; migraine with tinnitus patients showed not only decreased CN-VN connectivity in State 2 but also decreased cerebellar network and executive control network (CN-ECN) connectivity in State 2 and increased cerebellar network and somatomotor network (SMN-VN) connectivity in State 1. The abnormal cerebellum dFNC with the executive control network (CN-ECN) was negatively correlated with headache frequency of migraine (rho = −0.776, p = 0.005).ConclusionBrain network characteristics of migraine with tinnitus patients may indicate different mechanisms for migraine and tinnitus. Our results demonstrated a transient pathologic state with atypical cerebellar-cortical connectivity in migraine with tinnitus patients, which might be used to identify the neuro-pathophysiological mechanisms in migraine accompanied by tinnitus. |
| first_indexed | 2024-12-12T15:32:37Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-12T15:32:37Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-bbee8f2906c54a63bf320a5ee62131d42022-12-22T00:20:05ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-06-011410.3389/fnagi.2022.913191913191Aberrant Modulations of Neurocognitive Network Dynamics in Migraine Comorbid With TinnitusLiping Lan0Yin Liu1Jin-Jing Xu2Di Ma3Xindao Yin4Yuanqing Wu5Yu-Chen Chen6Yuexin Cai7Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Otolaryngology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaCollege of Information Science and Technology, Nanjing Forestry University, Nanjing, ChinaDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Otolaryngology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaPurposeThe possible relationship between migraine and tinnitus still remains elusive although migraine is often accompanied by chronic tinnitus. Several neuroimaging studies have reinforced the cognitive network abnormality in migraine and probably as well as tinnitus. The present work aims to investigate the dynamic neurocognitive network alterations of migraine comorbid with tinnitus.Materials and MethodsParticipants included migraine patients (n = 32), tinnitus patients (n = 20), migraine with tinnitus (n = 27), and healthy controls (n = 47), matched for age and gender. Resting-state functional magnetic resonance imaging (rs-fMRI) with independent component analysis (ICA), sliding window cross-correlation, and clustering state analysis was used to detect the dynamic functional network connectivity (dFNC) of each group. Correlation analyses illustrated the association between clinical symptoms and abnormal dFNC in migraine as well as tinnitus.ResultsCompared with healthy controls, migraine patients exhibited decreased cerebellar network and visual network (CN-VN) connectivity in State 2; migraine with tinnitus patients showed not only decreased CN-VN connectivity in State 2 but also decreased cerebellar network and executive control network (CN-ECN) connectivity in State 2 and increased cerebellar network and somatomotor network (SMN-VN) connectivity in State 1. The abnormal cerebellum dFNC with the executive control network (CN-ECN) was negatively correlated with headache frequency of migraine (rho = −0.776, p = 0.005).ConclusionBrain network characteristics of migraine with tinnitus patients may indicate different mechanisms for migraine and tinnitus. Our results demonstrated a transient pathologic state with atypical cerebellar-cortical connectivity in migraine with tinnitus patients, which might be used to identify the neuro-pathophysiological mechanisms in migraine accompanied by tinnitus.https://www.frontiersin.org/articles/10.3389/fnagi.2022.913191/fullmigrainetinnitusneurocognitive networkexecutive control networkfMRI |
| spellingShingle | Liping Lan Yin Liu Jin-Jing Xu Di Ma Xindao Yin Yuanqing Wu Yu-Chen Chen Yuexin Cai Aberrant Modulations of Neurocognitive Network Dynamics in Migraine Comorbid With Tinnitus Frontiers in Aging Neuroscience migraine tinnitus neurocognitive network executive control network fMRI |
| title | Aberrant Modulations of Neurocognitive Network Dynamics in Migraine Comorbid With Tinnitus |
| title_full | Aberrant Modulations of Neurocognitive Network Dynamics in Migraine Comorbid With Tinnitus |
| title_fullStr | Aberrant Modulations of Neurocognitive Network Dynamics in Migraine Comorbid With Tinnitus |
| title_full_unstemmed | Aberrant Modulations of Neurocognitive Network Dynamics in Migraine Comorbid With Tinnitus |
| title_short | Aberrant Modulations of Neurocognitive Network Dynamics in Migraine Comorbid With Tinnitus |
| title_sort | aberrant modulations of neurocognitive network dynamics in migraine comorbid with tinnitus |
| topic | migraine tinnitus neurocognitive network executive control network fMRI |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.913191/full |
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