Osteoblast Response to Copper-Doped Microporous Coatings on Titanium for Improved Bone Integration
Abstract Due to their excellent mechanical properties and good biocompatibility, titanium alloys have become a popular research topic in the field of medical metal implants. However, the surface of the titanium alloy does not exhibit biological activity, which may cause poor integration between the...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-09-01
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| Series: | Nanoscale Research Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s11671-021-03602-2 |
| _version_ | 1827841143346298880 |
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| author | Lai-jie Wang Xiao-hui Ni Fei Zhang Zhi Peng Fu-xun Yu Lei-bing Zhang Bo Li Yang Jiao Yan-kun Li Bing Yang Xing-yuan Zhu Quan-ming Zhao |
| author_facet | Lai-jie Wang Xiao-hui Ni Fei Zhang Zhi Peng Fu-xun Yu Lei-bing Zhang Bo Li Yang Jiao Yan-kun Li Bing Yang Xing-yuan Zhu Quan-ming Zhao |
| author_sort | Lai-jie Wang |
| collection | DOAJ |
| description | Abstract Due to their excellent mechanical properties and good biocompatibility, titanium alloys have become a popular research topic in the field of medical metal implants. However, the surface of the titanium alloy does not exhibit biological activity, which may cause poor integration between the interface of the titanium implant and the interface of the bone tissue and subsequently may cause the implant to fall off. Therefore, surface biological inertness is one of the problems that titanium alloys must overcome to become an ideal orthopedic implant material. Surface modification can improve the biological properties of titanium, thereby enhancing its osseointegration effect. Copper is an essential trace element for the human body, can promote bone formation and plays an important role in maintaining the physiological structure and function of bone and bone growth and development. In this study, a microporous copper-titanium dioxide coating was prepared on the surface of titanium by microarc oxidation. Based on the evaluation of its surface characteristics, the adhesion, proliferation and differentiation of MC3T3-E1 cells were observed. A titanium rod was implanted into the rabbit femoral condyle, and the integration of the coating and bone tissue was evaluated. Our research results show that the microporous copper-titanium dioxide coating has a nearly three-dimensional porous structure, and copper is incorporated into the coating without changing the structure of the coating. In vitro experiments found that the coating can promote the adhesion, proliferation and differentiation of MC3T3-E1 cells. In vivo experiments further confirmed that the titanium copper-titanium dioxide microporous coating can promote the osseointegration of titanium implants. In conclusion, copper-titanium dioxide microporous coatings can be prepared by microarc oxidation, which can improve the biological activity and biocompatibility of titanium, promote new bone formation and demonstrate good osteoinductive properties. Therefore, the use of this coating in orthopedics has potential clinical application. |
| first_indexed | 2024-03-12T07:47:09Z |
| format | Article |
| id | doaj.art-bbf0142ec9a84101b37762d1fcd9fa5c |
| institution | Directory Open Access Journal |
| issn | 1556-276X |
| language | English |
| last_indexed | 2024-03-12T07:47:09Z |
| publishDate | 2021-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nanoscale Research Letters |
| spelling | doaj.art-bbf0142ec9a84101b37762d1fcd9fa5c2023-09-02T20:56:16ZengSpringerOpenNanoscale Research Letters1556-276X2021-09-0116111510.1186/s11671-021-03602-2Osteoblast Response to Copper-Doped Microporous Coatings on Titanium for Improved Bone IntegrationLai-jie Wang0Xiao-hui Ni1Fei Zhang2Zhi Peng3Fu-xun Yu4Lei-bing Zhang5Bo Li6Yang Jiao7Yan-kun Li8Bing Yang9Xing-yuan Zhu10Quan-ming Zhao11Department of Orthopedics, Huai’an People’s Hospital of Hongze DistrictDepartment of Orthopedics, Dafeng People’s HospitalDepartment of Orthopedics, Huai’an People’s Hospital of Hongze DistrictDepartment of Orthopaedics, Guizhou Provincial People’s HospitalDepartment of Orthopaedics, Guizhou Provincial People’s HospitalDepartment of Orthopaedics, Guizhou Provincial People’s HospitalDepartment of Orthopaedics, Guizhou Provincial People’s HospitalDepartment of Orthopedics, Dafeng People’s HospitalDepartment of Orthopaedics, Guizhou Provincial People’s HospitalDepartment of Orthopedics, Dafeng People’s HospitalDepartment of Orthopedics, Dafeng People’s HospitalDepartment of Orthopaedics, Guizhou Provincial People’s HospitalAbstract Due to their excellent mechanical properties and good biocompatibility, titanium alloys have become a popular research topic in the field of medical metal implants. However, the surface of the titanium alloy does not exhibit biological activity, which may cause poor integration between the interface of the titanium implant and the interface of the bone tissue and subsequently may cause the implant to fall off. Therefore, surface biological inertness is one of the problems that titanium alloys must overcome to become an ideal orthopedic implant material. Surface modification can improve the biological properties of titanium, thereby enhancing its osseointegration effect. Copper is an essential trace element for the human body, can promote bone formation and plays an important role in maintaining the physiological structure and function of bone and bone growth and development. In this study, a microporous copper-titanium dioxide coating was prepared on the surface of titanium by microarc oxidation. Based on the evaluation of its surface characteristics, the adhesion, proliferation and differentiation of MC3T3-E1 cells were observed. A titanium rod was implanted into the rabbit femoral condyle, and the integration of the coating and bone tissue was evaluated. Our research results show that the microporous copper-titanium dioxide coating has a nearly three-dimensional porous structure, and copper is incorporated into the coating without changing the structure of the coating. In vitro experiments found that the coating can promote the adhesion, proliferation and differentiation of MC3T3-E1 cells. In vivo experiments further confirmed that the titanium copper-titanium dioxide microporous coating can promote the osseointegration of titanium implants. In conclusion, copper-titanium dioxide microporous coatings can be prepared by microarc oxidation, which can improve the biological activity and biocompatibility of titanium, promote new bone formation and demonstrate good osteoinductive properties. Therefore, the use of this coating in orthopedics has potential clinical application.https://doi.org/10.1186/s11671-021-03602-2Microarc oxidationCoatingOsteogenesisCopperOsseointegration |
| spellingShingle | Lai-jie Wang Xiao-hui Ni Fei Zhang Zhi Peng Fu-xun Yu Lei-bing Zhang Bo Li Yang Jiao Yan-kun Li Bing Yang Xing-yuan Zhu Quan-ming Zhao Osteoblast Response to Copper-Doped Microporous Coatings on Titanium for Improved Bone Integration Nanoscale Research Letters Microarc oxidation Coating Osteogenesis Copper Osseointegration |
| title | Osteoblast Response to Copper-Doped Microporous Coatings on Titanium for Improved Bone Integration |
| title_full | Osteoblast Response to Copper-Doped Microporous Coatings on Titanium for Improved Bone Integration |
| title_fullStr | Osteoblast Response to Copper-Doped Microporous Coatings on Titanium for Improved Bone Integration |
| title_full_unstemmed | Osteoblast Response to Copper-Doped Microporous Coatings on Titanium for Improved Bone Integration |
| title_short | Osteoblast Response to Copper-Doped Microporous Coatings on Titanium for Improved Bone Integration |
| title_sort | osteoblast response to copper doped microporous coatings on titanium for improved bone integration |
| topic | Microarc oxidation Coating Osteogenesis Copper Osseointegration |
| url | https://doi.org/10.1186/s11671-021-03602-2 |
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