Interstitial lung abnormalities after hospitalization for COVID‐19 in patients with cancer: A prospective cohort study
Abstract Introduction Survivors of SARS‐CoV‐2 pneumonia often develop persistent respiratory symptom and interstitial lung abnormalities (ILAs) after infection. Risk factors for ILA development and duration of ILA persistence after SARS‐CoV‐2 infection are not well described in immunocompromised hos...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-09-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.6396 |
| _version_ | 1797672376770494464 |
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| author | Sungryong Noh Christopher Bertini Isabel Mira‐Avendano Maryam Kaous Bela Patel Saadia A. Faiz Vickie R. Shannon Diwakar D. Balachandran Lara Bashoura Roberto Adachi Scott E. Evans Burton Dickey Carol Wu Girish S. Shroff Joanna‐Grace Manzano Bruno Granwehr Shannon Holloway Kodwo Dickson Alyssa Mohammed Mayoora Muthu Hui Song D3CODE Team Caroline Chung Jia Wu Lyndon Lee Ying Jiang Fareed Khawaja Ajay Sheshadri |
| author_facet | Sungryong Noh Christopher Bertini Isabel Mira‐Avendano Maryam Kaous Bela Patel Saadia A. Faiz Vickie R. Shannon Diwakar D. Balachandran Lara Bashoura Roberto Adachi Scott E. Evans Burton Dickey Carol Wu Girish S. Shroff Joanna‐Grace Manzano Bruno Granwehr Shannon Holloway Kodwo Dickson Alyssa Mohammed Mayoora Muthu Hui Song D3CODE Team Caroline Chung Jia Wu Lyndon Lee Ying Jiang Fareed Khawaja Ajay Sheshadri |
| author_sort | Sungryong Noh |
| collection | DOAJ |
| description | Abstract Introduction Survivors of SARS‐CoV‐2 pneumonia often develop persistent respiratory symptom and interstitial lung abnormalities (ILAs) after infection. Risk factors for ILA development and duration of ILA persistence after SARS‐CoV‐2 infection are not well described in immunocompromised hosts, such as cancer patients. Methods We conducted a prospective cohort study of 95 patients at a major cancer center and 45 patients at a tertiary referral center. We collected clinical and radiographic data during the index hospitalization for COVID‐19 pneumonia and measured pneumonia severity using a semi‐quantitative radiographic score, the Radiologic Severity Index (RSI). Patients were evaluated in post‐COVID‐19 clinics at 3 and 6 months after discharge and underwent comprehensive pulmonary evaluations (symptom assessment, chest computed tomography, pulmonary function tests, 6‐min walk test). The association of clinical and radiological factors with ILAs at 3 and 6 months post‐discharge was measured using univariable and multivariable logistic regression. Results Sixty‐six (70%) patients of cancer cohort had ILAs at 3 months, of whom 39 had persistent respiratory symptoms. Twenty‐four (26%) patients had persistent ILA at 6 months after hospital discharge. In adjusted models, higher peak RSI at admission was associated with ILAs at 3 (OR 1.5 per 5‐point increase, 95% CI 1.1–1.9) and 6 months (OR 1.3 per 5‐point increase, 95% CI 1.1–1.6) post‐discharge. Fibrotic ILAs (reticulation, traction bronchiectasis, and architectural distortion) were more common at 6 months post‐discharge. Conclusions Post‐COVID‐19 ILAs are common in cancer patients 3 months after hospital discharge, and peak RSI and older age are strong predictors of persistent ILAs. |
| first_indexed | 2024-03-11T21:29:09Z |
| format | Article |
| id | doaj.art-bbf22e59a32244e092ed4708195164af |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-03-11T21:29:09Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-bbf22e59a32244e092ed4708195164af2023-09-27T11:46:08ZengWileyCancer Medicine2045-76342023-09-011217177531776510.1002/cam4.6396Interstitial lung abnormalities after hospitalization for COVID‐19 in patients with cancer: A prospective cohort studySungryong Noh0Christopher Bertini1Isabel Mira‐Avendano2Maryam Kaous3Bela Patel4Saadia A. Faiz5Vickie R. Shannon6Diwakar D. Balachandran7Lara Bashoura8Roberto Adachi9Scott E. Evans10Burton Dickey11Carol Wu12Girish S. Shroff13Joanna‐Grace Manzano14Bruno Granwehr15Shannon Holloway16Kodwo Dickson17Alyssa Mohammed18Mayoora Muthu19Hui Song20D3CODE Team21Caroline Chung22Jia Wu23Lyndon Lee24Ying Jiang25Fareed Khawaja26Ajay Sheshadri27Division of Critical Care, Pulmonary and Sleep Medicine McGovern Medical School Houston Texas USADepartment of Internal Medicine McGovern Medical School at UT Health Houston Texas USADivision of Critical Care, Pulmonary and Sleep Medicine McGovern Medical School Houston Texas USADivision of Critical Care, Pulmonary and Sleep Medicine McGovern Medical School Houston Texas USADivision of Critical Care, Pulmonary and Sleep Medicine McGovern Medical School Houston Texas USADepartment of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Thoracic Imaging The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Thoracic Imaging The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Hospital Medicine The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Infectious Diseases, Infection Control, and Employee Health The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Infectious Diseases, Infection Control, and Employee Health The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Hospital Medicine The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Hospital Medicine The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Hospital Medicine The University of Texas MD Anderson Cancer Center Houston Texas USAData‐Driven Determinants for COVID‐19 Oncology Discovery Effort (D3CODE) Team The University of Texas MD Anderson Cancer Center Houston Texas USAData‐Driven Determinants for COVID‐19 Oncology Discovery Effort (D3CODE) Team The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Imaging Physics, Infection Control, and Employee Health The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Internal Medicine McGovern Medical School at UT Health Houston Texas USADepartment of Infectious Diseases, Infection Control, and Employee Health The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Infectious Diseases, Infection Control, and Employee Health The University of Texas MD Anderson Cancer Center Houston Texas USADepartment of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston Texas USAAbstract Introduction Survivors of SARS‐CoV‐2 pneumonia often develop persistent respiratory symptom and interstitial lung abnormalities (ILAs) after infection. Risk factors for ILA development and duration of ILA persistence after SARS‐CoV‐2 infection are not well described in immunocompromised hosts, such as cancer patients. Methods We conducted a prospective cohort study of 95 patients at a major cancer center and 45 patients at a tertiary referral center. We collected clinical and radiographic data during the index hospitalization for COVID‐19 pneumonia and measured pneumonia severity using a semi‐quantitative radiographic score, the Radiologic Severity Index (RSI). Patients were evaluated in post‐COVID‐19 clinics at 3 and 6 months after discharge and underwent comprehensive pulmonary evaluations (symptom assessment, chest computed tomography, pulmonary function tests, 6‐min walk test). The association of clinical and radiological factors with ILAs at 3 and 6 months post‐discharge was measured using univariable and multivariable logistic regression. Results Sixty‐six (70%) patients of cancer cohort had ILAs at 3 months, of whom 39 had persistent respiratory symptoms. Twenty‐four (26%) patients had persistent ILA at 6 months after hospital discharge. In adjusted models, higher peak RSI at admission was associated with ILAs at 3 (OR 1.5 per 5‐point increase, 95% CI 1.1–1.9) and 6 months (OR 1.3 per 5‐point increase, 95% CI 1.1–1.6) post‐discharge. Fibrotic ILAs (reticulation, traction bronchiectasis, and architectural distortion) were more common at 6 months post‐discharge. Conclusions Post‐COVID‐19 ILAs are common in cancer patients 3 months after hospital discharge, and peak RSI and older age are strong predictors of persistent ILAs.https://doi.org/10.1002/cam4.6396COVID‐19fibrosisinterstitial lung diseasepneumoniapost‐infectious pulmonary complication |
| spellingShingle | Sungryong Noh Christopher Bertini Isabel Mira‐Avendano Maryam Kaous Bela Patel Saadia A. Faiz Vickie R. Shannon Diwakar D. Balachandran Lara Bashoura Roberto Adachi Scott E. Evans Burton Dickey Carol Wu Girish S. Shroff Joanna‐Grace Manzano Bruno Granwehr Shannon Holloway Kodwo Dickson Alyssa Mohammed Mayoora Muthu Hui Song D3CODE Team Caroline Chung Jia Wu Lyndon Lee Ying Jiang Fareed Khawaja Ajay Sheshadri Interstitial lung abnormalities after hospitalization for COVID‐19 in patients with cancer: A prospective cohort study Cancer Medicine COVID‐19 fibrosis interstitial lung disease pneumonia post‐infectious pulmonary complication |
| title | Interstitial lung abnormalities after hospitalization for COVID‐19 in patients with cancer: A prospective cohort study |
| title_full | Interstitial lung abnormalities after hospitalization for COVID‐19 in patients with cancer: A prospective cohort study |
| title_fullStr | Interstitial lung abnormalities after hospitalization for COVID‐19 in patients with cancer: A prospective cohort study |
| title_full_unstemmed | Interstitial lung abnormalities after hospitalization for COVID‐19 in patients with cancer: A prospective cohort study |
| title_short | Interstitial lung abnormalities after hospitalization for COVID‐19 in patients with cancer: A prospective cohort study |
| title_sort | interstitial lung abnormalities after hospitalization for covid 19 in patients with cancer a prospective cohort study |
| topic | COVID‐19 fibrosis interstitial lung disease pneumonia post‐infectious pulmonary complication |
| url | https://doi.org/10.1002/cam4.6396 |
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