Butyric Acid Ameliorates Myocardial Fibrosis by Regulating M1/M2 Polarization of Macrophages and Promoting Recovery of Mitochondrial Function

Butyric Acid Ameliorates Myocardial Fibrosis by Regulating M1/M2 Polarization of Macrophages and Promoting Recovery of Mitochondrial Function

BackgroundWe aimed to investigate the effect and mechanism of butyric acid on rat myocardial fibrosis (MF).Methods16S rRNA sequencing was used to analyze the gut microbiota characteristics of the Sham group and MF group. HPLC was applied to measure butyric acid in the feces and serum. In vitro, rat...

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Bibliographic Details
Main Authors: Xiaogang Li, Ruixuan Li, Nana You, Xiexiong Zhao, Jiaying Li, Weihong Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Nutrition
Subjects:
butyric acid
myocardial fibrosis
macrophage polarization
mitochondria
gut microbiota
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2022.875473/full

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