Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical Variables
Björn Gerdle,1,2 Olof Dahlqvist Leinhard,2– 4 Eva Lund,3 Ann Bengtsson,1 Peter Lundberg,2,3 Bijar Ghafouri,1 Mikael Fredrik Forsgren2– 4 1Pain and Rehabilitation Centre, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, SE 581 83, Sweden; 2Centre for Medical Im...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-08-01
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| Series: | Journal of Pain Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/fibromyalgia-associations-between-fat-infiltration-physical-capacity-a-peer-reviewed-fulltext-article-JPR |
| _version_ | 1818054812244115456 |
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| author | Gerdle B Dahlqvist Leinhard O Lund E Bengtsson A Lundberg P Ghafouri B Forsgren MF |
| author_facet | Gerdle B Dahlqvist Leinhard O Lund E Bengtsson A Lundberg P Ghafouri B Forsgren MF |
| author_sort | Gerdle B |
| collection | DOAJ |
| description | Björn Gerdle,1,2 Olof Dahlqvist Leinhard,2– 4 Eva Lund,3 Ann Bengtsson,1 Peter Lundberg,2,3 Bijar Ghafouri,1 Mikael Fredrik Forsgren2– 4 1Pain and Rehabilitation Centre, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, SE 581 83, Sweden; 2Centre for Medical Image Science and Visualization (CMIV), Linköping, SE 581 83, Sweden; 3Department of Radiation Physics, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, SE 581 83, Sweden; 4AMRA Medical AB, Linköping, SwedenCorrespondence: Björn Gerdle, Tel +46763927191, Email bjorn.gerdle@liu.seBackground: Obesity is a risk factor for the development of fibromyalgia (FM) and generally most studies report increased Body Mass Index (BMI) in FM. Obesity in FM is associated with a worse clinical presentation. FM patients have low physical conditioning and obesity further exacerbates these aspects. Hitherto studies of FM have focused upon a surrogate for overall measure of fat content, ie, BMI. This study is motivated by that ectopic fat and adipose tissues are rarely investigated in FM including their relationships to physical capacity variables. Moreover, their relationships to clinical variables including are not known. Aims were to 1) compare body composition between FM and healthy controls and 2) investigate if significant associations exist between body composition and physical capacity aspects and important clinical variables.Methods: FM patients (n = 32) and healthy controls (CON; n = 30) underwent a clinical examination that included pressure pain thresholds and physical tests. They completed a health questionnaire and participated in whole-body magnetic resonance imaging (MRI) to determine body composition aspects.Results: Abdominal adipose tissues, muscle fat, and BMI were significantly higher in FM, whereas muscle volumes of quadriceps were smaller. Physical capacity variables correlated negatively with body composition variables in FM. Both body composition and physical capacity variables were significant regressors of group belonging; the physical capacity variables alone showed stronger relationships with group membership. A mix of body composition variables and physical capacity variables were significant regressors of pain intensity and impact in FM. Body composition variables were the strongest regressors of blood pressures, which were increased in FM.Conclusion: Obesity has a negative influence on FM symptomatology and increases the risk for other serious conditions. Hence, obesity, dietary habits, and physical activity should be considered when developing clinical management plans for patients with FM.Keywords: body mass index, chronic pain, fibromyalgia, physical fitness, muscle, fat, magnetic resonance imaging, body composition |
| first_indexed | 2024-12-10T12:03:00Z |
| format | Article |
| id | doaj.art-bbf27986e2d443f6ba1b13ac44003955 |
| institution | Directory Open Access Journal |
| issn | 1178-7090 |
| language | English |
| last_indexed | 2024-12-10T12:03:00Z |
| publishDate | 2022-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Pain Research |
| spelling | doaj.art-bbf27986e2d443f6ba1b13ac440039552022-12-22T01:49:33ZengDove Medical PressJournal of Pain Research1178-70902022-08-01Volume 152517253577716Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical VariablesGerdle BDahlqvist Leinhard OLund EBengtsson ALundberg PGhafouri BForsgren MFBjörn Gerdle,1,2 Olof Dahlqvist Leinhard,2– 4 Eva Lund,3 Ann Bengtsson,1 Peter Lundberg,2,3 Bijar Ghafouri,1 Mikael Fredrik Forsgren2– 4 1Pain and Rehabilitation Centre, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, SE 581 83, Sweden; 2Centre for Medical Image Science and Visualization (CMIV), Linköping, SE 581 83, Sweden; 3Department of Radiation Physics, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, SE 581 83, Sweden; 4AMRA Medical AB, Linköping, SwedenCorrespondence: Björn Gerdle, Tel +46763927191, Email bjorn.gerdle@liu.seBackground: Obesity is a risk factor for the development of fibromyalgia (FM) and generally most studies report increased Body Mass Index (BMI) in FM. Obesity in FM is associated with a worse clinical presentation. FM patients have low physical conditioning and obesity further exacerbates these aspects. Hitherto studies of FM have focused upon a surrogate for overall measure of fat content, ie, BMI. This study is motivated by that ectopic fat and adipose tissues are rarely investigated in FM including their relationships to physical capacity variables. Moreover, their relationships to clinical variables including are not known. Aims were to 1) compare body composition between FM and healthy controls and 2) investigate if significant associations exist between body composition and physical capacity aspects and important clinical variables.Methods: FM patients (n = 32) and healthy controls (CON; n = 30) underwent a clinical examination that included pressure pain thresholds and physical tests. They completed a health questionnaire and participated in whole-body magnetic resonance imaging (MRI) to determine body composition aspects.Results: Abdominal adipose tissues, muscle fat, and BMI were significantly higher in FM, whereas muscle volumes of quadriceps were smaller. Physical capacity variables correlated negatively with body composition variables in FM. Both body composition and physical capacity variables were significant regressors of group belonging; the physical capacity variables alone showed stronger relationships with group membership. A mix of body composition variables and physical capacity variables were significant regressors of pain intensity and impact in FM. Body composition variables were the strongest regressors of blood pressures, which were increased in FM.Conclusion: Obesity has a negative influence on FM symptomatology and increases the risk for other serious conditions. Hence, obesity, dietary habits, and physical activity should be considered when developing clinical management plans for patients with FM.Keywords: body mass index, chronic pain, fibromyalgia, physical fitness, muscle, fat, magnetic resonance imaging, body compositionhttps://www.dovepress.com/fibromyalgia-associations-between-fat-infiltration-physical-capacity-a-peer-reviewed-fulltext-article-JPRbody mass indexchronic painfibromyalgiaphysical fitnessmusclefatmagnetic resonance imagingbody composition |
| spellingShingle | Gerdle B Dahlqvist Leinhard O Lund E Bengtsson A Lundberg P Ghafouri B Forsgren MF Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical Variables Journal of Pain Research body mass index chronic pain fibromyalgia physical fitness muscle fat magnetic resonance imaging body composition |
| title | Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical Variables |
| title_full | Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical Variables |
| title_fullStr | Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical Variables |
| title_full_unstemmed | Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical Variables |
| title_short | Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical Variables |
| title_sort | fibromyalgia associations between fat infiltration physical capacity and clinical variables |
| topic | body mass index chronic pain fibromyalgia physical fitness muscle fat magnetic resonance imaging body composition |
| url | https://www.dovepress.com/fibromyalgia-associations-between-fat-infiltration-physical-capacity-a-peer-reviewed-fulltext-article-JPR |
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