Plant Polyphenols Inhibit Functional Amyloid and Biofilm Formation in <i>Pseudomonas</i> Strains by Directing Monomers to Off-Pathway Oligomers

Plant Polyphenols Inhibit Functional Amyloid and Biofilm Formation in <i>Pseudomonas</i> Strains by Directing Monomers to Off-Pathway Oligomers

Self-assembly of proteins to &#946;-sheet rich amyloid fibrils is commonly observed in various neurodegenerative diseases. However, amyloid also occurs in the extracellular matrix of bacterial biofilm, which protects bacteria from environmental stress and antibiotics. Many <i>Pseudomonas&l...

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Bibliographic Details
Main Authors: Zahra Najarzadeh, Hossein Mohammad-Beigi, Jannik Nedergaard Pedersen, Gunna Christiansen, Thorbjørn Vincent Sønderby, Seyed Abbas Shojaosadati, Dina Morshedi, Kristian Strømgaard, Georg Meisl, Duncan Sutherland, Jan Skov Pedersen, Daniel E. Otzen
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Biomolecules
Subjects:
bacterial amyloid
fapc protein
extracellular matrix
aggregation inhibitor
peptide array
Online Access:https://www.mdpi.com/2218-273X/9/11/659

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