Endothelial microparticles: A mechanosensitive regulator of vascular homeostasis and injury under shear stress
Hemodynamic shear stress (SS), a frictional force generated by blood flow, regulates vascular homeostasis. High and steady SS maintains physiological function of endothelial cells while low and disturbed SS promotes disturbance of vascular homeostasis and the development of atherosclerosis. Endothel...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.980112/full |
| _version_ | 1828113224245968896 |
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| author | Shuo Feng Jia Wei Chen Xin Yi Shu Muladili Aihemaiti Jin Wei Quan Lin Lu Lin Lu Rui Yan Zhang Chen Die Yang Xiao Qun Wang Xiao Qun Wang |
| author_facet | Shuo Feng Jia Wei Chen Xin Yi Shu Muladili Aihemaiti Jin Wei Quan Lin Lu Lin Lu Rui Yan Zhang Chen Die Yang Xiao Qun Wang Xiao Qun Wang |
| author_sort | Shuo Feng |
| collection | DOAJ |
| description | Hemodynamic shear stress (SS), a frictional force generated by blood flow, regulates vascular homeostasis. High and steady SS maintains physiological function of endothelial cells while low and disturbed SS promotes disturbance of vascular homeostasis and the development of atherosclerosis. Endothelial microparticle (EMP), a vesicular structure shed from endothelial cells, has emerged as a surrogate biomarker of endothelial injury and dysfunction. EMP release is triggered by disturbed SS in addition to multiple inflammatory cytokines. This review systematically summarizes the impact of SS on EMPs and the role of EMPs under SS in modulating vascular homeostasis and injury, including endothelial survival, vasodilation, inflammatory response, vascular permeability, and coagulation system. |
| first_indexed | 2024-04-11T12:03:16Z |
| format | Article |
| id | doaj.art-bbf2c61124ed45d78273f5c4b67657cc |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-11T12:03:16Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-bbf2c61124ed45d78273f5c4b67657cc2022-12-22T04:24:48ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-09-011010.3389/fcell.2022.980112980112Endothelial microparticles: A mechanosensitive regulator of vascular homeostasis and injury under shear stressShuo Feng0Jia Wei Chen1Xin Yi Shu2Muladili Aihemaiti3Jin Wei Quan4Lin Lu5Lin Lu6Rui Yan Zhang7Chen Die Yang8Xiao Qun Wang9Xiao Qun Wang10Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, ChinaInstitute of Cardiovascular Disease, Shanghai Jiao-Tong University School of Medicine, Shanghai, ChinaInstitute of Cardiovascular Disease, Shanghai Jiao-Tong University School of Medicine, Shanghai, ChinaInstitute of Cardiovascular Disease, Shanghai Jiao-Tong University School of Medicine, Shanghai, ChinaInstitute of Cardiovascular Disease, Shanghai Jiao-Tong University School of Medicine, Shanghai, ChinaDepartment of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, ChinaInstitute of Cardiovascular Disease, Shanghai Jiao-Tong University School of Medicine, Shanghai, ChinaDepartment of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, ChinaDepartment of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, ChinaDepartment of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, ChinaInstitute of Cardiovascular Disease, Shanghai Jiao-Tong University School of Medicine, Shanghai, ChinaHemodynamic shear stress (SS), a frictional force generated by blood flow, regulates vascular homeostasis. High and steady SS maintains physiological function of endothelial cells while low and disturbed SS promotes disturbance of vascular homeostasis and the development of atherosclerosis. Endothelial microparticle (EMP), a vesicular structure shed from endothelial cells, has emerged as a surrogate biomarker of endothelial injury and dysfunction. EMP release is triggered by disturbed SS in addition to multiple inflammatory cytokines. This review systematically summarizes the impact of SS on EMPs and the role of EMPs under SS in modulating vascular homeostasis and injury, including endothelial survival, vasodilation, inflammatory response, vascular permeability, and coagulation system.https://www.frontiersin.org/articles/10.3389/fcell.2022.980112/fullshear stressendothelial microparticlesvascular homeostasisendothelial dysfunctionatherosclerosis |
| spellingShingle | Shuo Feng Jia Wei Chen Xin Yi Shu Muladili Aihemaiti Jin Wei Quan Lin Lu Lin Lu Rui Yan Zhang Chen Die Yang Xiao Qun Wang Xiao Qun Wang Endothelial microparticles: A mechanosensitive regulator of vascular homeostasis and injury under shear stress Frontiers in Cell and Developmental Biology shear stress endothelial microparticles vascular homeostasis endothelial dysfunction atherosclerosis |
| title | Endothelial microparticles: A mechanosensitive regulator of vascular homeostasis and injury under shear stress |
| title_full | Endothelial microparticles: A mechanosensitive regulator of vascular homeostasis and injury under shear stress |
| title_fullStr | Endothelial microparticles: A mechanosensitive regulator of vascular homeostasis and injury under shear stress |
| title_full_unstemmed | Endothelial microparticles: A mechanosensitive regulator of vascular homeostasis and injury under shear stress |
| title_short | Endothelial microparticles: A mechanosensitive regulator of vascular homeostasis and injury under shear stress |
| title_sort | endothelial microparticles a mechanosensitive regulator of vascular homeostasis and injury under shear stress |
| topic | shear stress endothelial microparticles vascular homeostasis endothelial dysfunction atherosclerosis |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.980112/full |
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