Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells
Abstract Today, many materials as drug are developed having various prominent function in order to treatment of disease or cancer. Among these materials, especially docosahexaenoic acid (DHA), main constituents of omega-3 fatty acid, has a lot of beneficial and natural effects, so it has been known...
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| Format: | Article |
| Language: | English |
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Kosin University College of Medicine
2015-12-01
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| Series: | Kosin Medical Journal |
| Subjects: | |
| Online Access: | http://www.kosinmedj.org/upload/pdf/ksmc030-2-01.pdf |
| _version_ | 1811192625709973504 |
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| author | Sun-yong Hwang Tae-Hee Kim Hae-Hyeog Lee Heung Yeol Kim Juhyun Seo |
| author_facet | Sun-yong Hwang Tae-Hee Kim Hae-Hyeog Lee Heung Yeol Kim Juhyun Seo |
| author_sort | Sun-yong Hwang |
| collection | DOAJ |
| description | Abstract Today, many materials as drug are developed having various prominent function in order to treatment of disease or cancer. Among these materials, especially docosahexaenoic acid (DHA), main constituents of omega-3 fatty acid, has a lot of beneficial and natural effects, so it has been known as anticancer material especially breast cancer. Breast cancer is disease taking high occurrence level among feminine diseases. DHA has anticancer effects on breast cancer cell, representatively inducing apoptosis, inhibiting proliferation or metastasis. Main effect of DHA on breast cancer cell is apoptosis inducing, which has mechanism that treated DHA causes lipid peroxidation increasing reactive oxygen species (ROS) level and it activates caspase 8 and caspase 9 so activated caspase occurs apoptosis. Cell lines of breast cancer are MDA-MB-231, MCF-7, SK-BR-3, T47D and ZR75. Especially this article uses the MCF-7 cell line at experiment of anti-proliferation by DHA, the MDA-MB-231 cell line at experiment of anti-metastasis by DHA, because that cell line has specialized metastasis activity. Therefore, this paper discusses the effects of natural material DHA as drug of breast cancer. |
| first_indexed | 2024-04-11T23:55:31Z |
| format | Article |
| id | doaj.art-bbf3ac17a7d542588947a66314b19002 |
| institution | Directory Open Access Journal |
| issn | 2005-9531 2586-7024 |
| language | English |
| last_indexed | 2024-04-11T23:55:31Z |
| publishDate | 2015-12-01 |
| publisher | Kosin University College of Medicine |
| record_format | Article |
| series | Kosin Medical Journal |
| spelling | doaj.art-bbf3ac17a7d542588947a66314b190022022-12-22T03:56:22ZengKosin University College of MedicineKosin Medical Journal2005-95312586-70242015-12-0130210310710.7180/kmj.2015.30.2.103157Effect of Docosahexaenoic Acid (DHA) on Breast Cancer CellsSun-yong Hwang0Tae-Hee Kim1Hae-Hyeog Lee2Heung Yeol Kim3Juhyun Seo4Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang University Graduate School, Asan, Republic of KoreaDepartment of Obstetrics and Gynecology, College of Medicine, Soonchunhyang University, Bucheon, Republic of KoreaDepartment of Obstetrics and Gynecology, College of Medicine, Soonchunhyang University, Bucheon, Republic of KoreaDepartment of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Republic of KoreaDepartment of Life Science and Biotechnology, Soonchunhyang University College of Natural Sciences, Asan, Republic of KoreaAbstract Today, many materials as drug are developed having various prominent function in order to treatment of disease or cancer. Among these materials, especially docosahexaenoic acid (DHA), main constituents of omega-3 fatty acid, has a lot of beneficial and natural effects, so it has been known as anticancer material especially breast cancer. Breast cancer is disease taking high occurrence level among feminine diseases. DHA has anticancer effects on breast cancer cell, representatively inducing apoptosis, inhibiting proliferation or metastasis. Main effect of DHA on breast cancer cell is apoptosis inducing, which has mechanism that treated DHA causes lipid peroxidation increasing reactive oxygen species (ROS) level and it activates caspase 8 and caspase 9 so activated caspase occurs apoptosis. Cell lines of breast cancer are MDA-MB-231, MCF-7, SK-BR-3, T47D and ZR75. Especially this article uses the MCF-7 cell line at experiment of anti-proliferation by DHA, the MDA-MB-231 cell line at experiment of anti-metastasis by DHA, because that cell line has specialized metastasis activity. Therefore, this paper discusses the effects of natural material DHA as drug of breast cancer.http://www.kosinmedj.org/upload/pdf/ksmc030-2-01.pdfapoptosisbreast neoplasmsdocosahexaenoic acidmetastasisproliferation |
| spellingShingle | Sun-yong Hwang Tae-Hee Kim Hae-Hyeog Lee Heung Yeol Kim Juhyun Seo Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells Kosin Medical Journal apoptosis breast neoplasms docosahexaenoic acid metastasis proliferation |
| title | Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells |
| title_full | Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells |
| title_fullStr | Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells |
| title_full_unstemmed | Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells |
| title_short | Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells |
| title_sort | effect of docosahexaenoic acid dha on breast cancer cells |
| topic | apoptosis breast neoplasms docosahexaenoic acid metastasis proliferation |
| url | http://www.kosinmedj.org/upload/pdf/ksmc030-2-01.pdf |
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