Quantifying Patient-Specific in vivo Coronary Plaque Material Properties for Accurate Stress/Strain Calculations: An IVUS-Based Multi-Patient Study
Introduction: Mechanical forces are closely associated with plaque progression and rupture. Precise quantifications of biomechanical conditions using in vivo image-based computational models depend heavily on the accurate estimation of patient-specific plaque mechanical properties. Currently, mechan...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-10-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.721195/full |
| _version_ | 1818919455204311040 |
|---|---|
| author | Liang Wang Jian Zhu Akiko Maehara Rui Lv Yangyang Qu Xiaoguo Zhang Xiaoya Guo Kristen L. Billiar Lijuan Chen Genshan Ma Gary S. Mintz Dalin Tang Dalin Tang |
| author_facet | Liang Wang Jian Zhu Akiko Maehara Rui Lv Yangyang Qu Xiaoguo Zhang Xiaoya Guo Kristen L. Billiar Lijuan Chen Genshan Ma Gary S. Mintz Dalin Tang Dalin Tang |
| author_sort | Liang Wang |
| collection | DOAJ |
| description | Introduction: Mechanical forces are closely associated with plaque progression and rupture. Precise quantifications of biomechanical conditions using in vivo image-based computational models depend heavily on the accurate estimation of patient-specific plaque mechanical properties. Currently, mechanical experiments are commonly performed on ex vivo cardiovascular tissues to determine plaque material properties. Patient-specific in vivo coronary material properties are scarce in the existing literature.Methods:In vivo Cine intravascular ultrasound and virtual histology intravascular ultrasound (IVUS) slices were acquired at 20 plaque sites from 13 patients. A three-dimensional thin-slice structure-only model was constructed for each slice to obtain patient-specific in vivo material parameter values following an iterative scheme. Effective Young's modulus (YM) was calculated to indicate plaque stiffness for easy comparison purposes. IVUS-based 3D thin-slice models using in vivo and ex vivo material properties were constructed to investigate their impacts on plaque wall stress/strain (PWS/PWSn) calculations.Results: The average YM values in the axial and circumferential directions for the 20 plaque slices were 599.5 and 1,042.8 kPa, respectively, 36.1% lower than those from published ex vivo data. The YM values in the circumferential direction of the softest and stiffest plaques were 103.4 and 2,317.3 kPa, respectively. The relative difference of mean PWSn on lumen using the in vivo and ex vivo material properties could be as high as 431%, while the relative difference of mean PWS was much lower, about 3.07% on average.Conclusion: There is a large inter-patient and intra-patient variability in the in vivo plaque material properties. In vivo material properties have a great impact on plaque stress/strain calculations. In vivo plaque material properties have a greater impact on strain calculations. Large-scale-patient studies are needed to further verify our findings. |
| first_indexed | 2024-12-20T01:06:08Z |
| format | Article |
| id | doaj.art-bbf432c37e164a818a1ae9d560112545 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-20T01:06:08Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-bbf432c37e164a818a1ae9d5601125452022-12-21T19:58:51ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-10-011210.3389/fphys.2021.721195721195Quantifying Patient-Specific in vivo Coronary Plaque Material Properties for Accurate Stress/Strain Calculations: An IVUS-Based Multi-Patient StudyLiang Wang0Jian Zhu1Akiko Maehara2Rui Lv3Yangyang Qu4Xiaoguo Zhang5Xiaoya Guo6Kristen L. Billiar7Lijuan Chen8Genshan Ma9Gary S. Mintz10Dalin Tang11Dalin Tang12School of Biological Science and Medical Engineering, Southeast University, Nanjing, ChinaDepartment of Cardiology, Zhongda Hospital, Southeast University, Nanjing, ChinaThe Cardiovascular Research Foundation, Columbia University, New York, NY, United StatesSchool of Biological Science and Medical Engineering, Southeast University, Nanjing, ChinaDepartment of Cardiology, Zhongda Hospital, Southeast University, Nanjing, ChinaDepartment of Cardiology, Zhongda Hospital, Southeast University, Nanjing, ChinaSchool of Science, Nanjing University of Posts and Telecommunications, Nanjing, ChinaDepartment of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, United StatesDepartment of Cardiology, Zhongda Hospital, Southeast University, Nanjing, ChinaDepartment of Cardiology, Zhongda Hospital, Southeast University, Nanjing, ChinaThe Cardiovascular Research Foundation, Columbia University, New York, NY, United StatesSchool of Biological Science and Medical Engineering, Southeast University, Nanjing, ChinaMathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA, United StatesIntroduction: Mechanical forces are closely associated with plaque progression and rupture. Precise quantifications of biomechanical conditions using in vivo image-based computational models depend heavily on the accurate estimation of patient-specific plaque mechanical properties. Currently, mechanical experiments are commonly performed on ex vivo cardiovascular tissues to determine plaque material properties. Patient-specific in vivo coronary material properties are scarce in the existing literature.Methods:In vivo Cine intravascular ultrasound and virtual histology intravascular ultrasound (IVUS) slices were acquired at 20 plaque sites from 13 patients. A three-dimensional thin-slice structure-only model was constructed for each slice to obtain patient-specific in vivo material parameter values following an iterative scheme. Effective Young's modulus (YM) was calculated to indicate plaque stiffness for easy comparison purposes. IVUS-based 3D thin-slice models using in vivo and ex vivo material properties were constructed to investigate their impacts on plaque wall stress/strain (PWS/PWSn) calculations.Results: The average YM values in the axial and circumferential directions for the 20 plaque slices were 599.5 and 1,042.8 kPa, respectively, 36.1% lower than those from published ex vivo data. The YM values in the circumferential direction of the softest and stiffest plaques were 103.4 and 2,317.3 kPa, respectively. The relative difference of mean PWSn on lumen using the in vivo and ex vivo material properties could be as high as 431%, while the relative difference of mean PWS was much lower, about 3.07% on average.Conclusion: There is a large inter-patient and intra-patient variability in the in vivo plaque material properties. In vivo material properties have a great impact on plaque stress/strain calculations. In vivo plaque material properties have a greater impact on strain calculations. Large-scale-patient studies are needed to further verify our findings.https://www.frontiersin.org/articles/10.3389/fphys.2021.721195/fullcoronary plaquein vivo material propertiesvulnerable plaqueartery material propertiesplaque stressartery model |
| spellingShingle | Liang Wang Jian Zhu Akiko Maehara Rui Lv Yangyang Qu Xiaoguo Zhang Xiaoya Guo Kristen L. Billiar Lijuan Chen Genshan Ma Gary S. Mintz Dalin Tang Dalin Tang Quantifying Patient-Specific in vivo Coronary Plaque Material Properties for Accurate Stress/Strain Calculations: An IVUS-Based Multi-Patient Study Frontiers in Physiology coronary plaque in vivo material properties vulnerable plaque artery material properties plaque stress artery model |
| title | Quantifying Patient-Specific in vivo Coronary Plaque Material Properties for Accurate Stress/Strain Calculations: An IVUS-Based Multi-Patient Study |
| title_full | Quantifying Patient-Specific in vivo Coronary Plaque Material Properties for Accurate Stress/Strain Calculations: An IVUS-Based Multi-Patient Study |
| title_fullStr | Quantifying Patient-Specific in vivo Coronary Plaque Material Properties for Accurate Stress/Strain Calculations: An IVUS-Based Multi-Patient Study |
| title_full_unstemmed | Quantifying Patient-Specific in vivo Coronary Plaque Material Properties for Accurate Stress/Strain Calculations: An IVUS-Based Multi-Patient Study |
| title_short | Quantifying Patient-Specific in vivo Coronary Plaque Material Properties for Accurate Stress/Strain Calculations: An IVUS-Based Multi-Patient Study |
| title_sort | quantifying patient specific in vivo coronary plaque material properties for accurate stress strain calculations an ivus based multi patient study |
| topic | coronary plaque in vivo material properties vulnerable plaque artery material properties plaque stress artery model |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.721195/full |
| work_keys_str_mv | AT liangwang quantifyingpatientspecificinvivocoronaryplaquematerialpropertiesforaccuratestressstraincalculationsanivusbasedmultipatientstudy AT jianzhu quantifyingpatientspecificinvivocoronaryplaquematerialpropertiesforaccuratestressstraincalculationsanivusbasedmultipatientstudy AT akikomaehara quantifyingpatientspecificinvivocoronaryplaquematerialpropertiesforaccuratestressstraincalculationsanivusbasedmultipatientstudy AT ruilv quantifyingpatientspecificinvivocoronaryplaquematerialpropertiesforaccuratestressstraincalculationsanivusbasedmultipatientstudy AT yangyangqu quantifyingpatientspecificinvivocoronaryplaquematerialpropertiesforaccuratestressstraincalculationsanivusbasedmultipatientstudy AT xiaoguozhang quantifyingpatientspecificinvivocoronaryplaquematerialpropertiesforaccuratestressstraincalculationsanivusbasedmultipatientstudy AT xiaoyaguo quantifyingpatientspecificinvivocoronaryplaquematerialpropertiesforaccuratestressstraincalculationsanivusbasedmultipatientstudy AT kristenlbilliar quantifyingpatientspecificinvivocoronaryplaquematerialpropertiesforaccuratestressstraincalculationsanivusbasedmultipatientstudy AT lijuanchen quantifyingpatientspecificinvivocoronaryplaquematerialpropertiesforaccuratestressstraincalculationsanivusbasedmultipatientstudy AT genshanma quantifyingpatientspecificinvivocoronaryplaquematerialpropertiesforaccuratestressstraincalculationsanivusbasedmultipatientstudy AT garysmintz quantifyingpatientspecificinvivocoronaryplaquematerialpropertiesforaccuratestressstraincalculationsanivusbasedmultipatientstudy AT dalintang quantifyingpatientspecificinvivocoronaryplaquematerialpropertiesforaccuratestressstraincalculationsanivusbasedmultipatientstudy AT dalintang quantifyingpatientspecificinvivocoronaryplaquematerialpropertiesforaccuratestressstraincalculationsanivusbasedmultipatientstudy |