Application of photo-responsive metal-organic framework in cancer therapy and bioimaging
Metal-organic frameworks (MOFs) are a class of hybrid porous crystalline materials that are assembled with metal ions/clusters and organic linkers. The fungibility of organic ligands and metal centers endow MOFs that are easy to design and synthesize. Based on their unique structure, multifarious MO...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1031986/full |
| _version_ | 1811337348768595968 |
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| author | Yujie Zhao Xian Jiang Xu Liu Xu Liu Xinyu Liu Zhihui Liu Xiaowei Liu |
| author_facet | Yujie Zhao Xian Jiang Xu Liu Xu Liu Xinyu Liu Zhihui Liu Xiaowei Liu |
| author_sort | Yujie Zhao |
| collection | DOAJ |
| description | Metal-organic frameworks (MOFs) are a class of hybrid porous crystalline materials that are assembled with metal ions/clusters and organic linkers. The fungibility of organic ligands and metal centers endow MOFs that are easy to design and synthesize. Based on their unique structure, multifarious MOFs with diverse functionalities have recently been widely applied in various research areas. Particularly striking is the application of photo-responsive MOFs in biological sensing and imaging. Notably, the photoelectronic properties make photo-responsive MOFs an ideal platform for cancer phototherapy. Moreover, ultrahigh porosities and tunable pore sizes allow MOFs to load anticancer drugs, further enhancing the antitumor efficiency. In this review, the categories and developing strategies of MOFs are briefly introduced. The application fields of MOFs in bioimaging, such as up-conversion fluorescence imaging, single/two-photon fluorescence bioimaging, magnetic resonance imaging, etc., are summarized. The working mechanism of MOFs in photo-responsive, photothermal therapy (PTT), and photodynamic therapy (PDT) are expounded. Examples of using MOFs for cancer treatment, including PTT, PDT, chemotherapy, and radiotherapy, are also demonstrated. Lastly, current limitations, challenges, and future perspectives for bioimaging and cancer treatment of MOFs are discussed. We believe that the versatile MOF will bring the dawn to the next generation of cancer treatment. |
| first_indexed | 2024-04-13T17:53:34Z |
| format | Article |
| id | doaj.art-bbf53928771743d593fa15ea1bb82a96 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-13T17:53:34Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-bbf53928771743d593fa15ea1bb82a962022-12-22T02:36:36ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-10-011010.3389/fbioe.2022.10319861031986Application of photo-responsive metal-organic framework in cancer therapy and bioimagingYujie Zhao0Xian Jiang1Xu Liu2Xu Liu3Xinyu Liu4Zhihui Liu5Xiaowei Liu6Laboratory of Integrative Medicine, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaLaboratory of Integrative Medicine, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaLaboratory of Integrative Medicine, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Head, Neck and Mammary Gland Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaLaboratory of Integrative Medicine, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaLaboratory of Integrative Medicine, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaLaboratory of Integrative Medicine, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaMetal-organic frameworks (MOFs) are a class of hybrid porous crystalline materials that are assembled with metal ions/clusters and organic linkers. The fungibility of organic ligands and metal centers endow MOFs that are easy to design and synthesize. Based on their unique structure, multifarious MOFs with diverse functionalities have recently been widely applied in various research areas. Particularly striking is the application of photo-responsive MOFs in biological sensing and imaging. Notably, the photoelectronic properties make photo-responsive MOFs an ideal platform for cancer phototherapy. Moreover, ultrahigh porosities and tunable pore sizes allow MOFs to load anticancer drugs, further enhancing the antitumor efficiency. In this review, the categories and developing strategies of MOFs are briefly introduced. The application fields of MOFs in bioimaging, such as up-conversion fluorescence imaging, single/two-photon fluorescence bioimaging, magnetic resonance imaging, etc., are summarized. The working mechanism of MOFs in photo-responsive, photothermal therapy (PTT), and photodynamic therapy (PDT) are expounded. Examples of using MOFs for cancer treatment, including PTT, PDT, chemotherapy, and radiotherapy, are also demonstrated. Lastly, current limitations, challenges, and future perspectives for bioimaging and cancer treatment of MOFs are discussed. We believe that the versatile MOF will bring the dawn to the next generation of cancer treatment.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1031986/fullmetal-organic frameworkbioimagingphotothermal therapyphotodynamic therapycancer therapy |
| spellingShingle | Yujie Zhao Xian Jiang Xu Liu Xu Liu Xinyu Liu Zhihui Liu Xiaowei Liu Application of photo-responsive metal-organic framework in cancer therapy and bioimaging Frontiers in Bioengineering and Biotechnology metal-organic framework bioimaging photothermal therapy photodynamic therapy cancer therapy |
| title | Application of photo-responsive metal-organic framework in cancer therapy and bioimaging |
| title_full | Application of photo-responsive metal-organic framework in cancer therapy and bioimaging |
| title_fullStr | Application of photo-responsive metal-organic framework in cancer therapy and bioimaging |
| title_full_unstemmed | Application of photo-responsive metal-organic framework in cancer therapy and bioimaging |
| title_short | Application of photo-responsive metal-organic framework in cancer therapy and bioimaging |
| title_sort | application of photo responsive metal organic framework in cancer therapy and bioimaging |
| topic | metal-organic framework bioimaging photothermal therapy photodynamic therapy cancer therapy |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1031986/full |
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