Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin
DNA methylation and H3K9 dimethylation are two linked epigenetic marks of silenced chromatin in plants that depend on the activity of CMT3/2 and SUVH4/5/6. Here the authors identify AGDP1 as an H3K9me2-binding protein required for heterochromatic non-CG DNA methylation, H3K9 dimethylation, and trans...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06965-w |
| _version_ | 1818398526019731456 |
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| author | Cuijun Zhang Xuan Du Kai Tang Zhenlin Yang Li Pan Peipei Zhu Jinyan Luo Yuwei Jiang Hui Zhang Huafang Wan Xingang Wang Fengkai Wu W. Andy Tao Xin-Jian He Heng Zhang Ray A. Bressan Jiamu Du Jian-Kang Zhu |
| author_facet | Cuijun Zhang Xuan Du Kai Tang Zhenlin Yang Li Pan Peipei Zhu Jinyan Luo Yuwei Jiang Hui Zhang Huafang Wan Xingang Wang Fengkai Wu W. Andy Tao Xin-Jian He Heng Zhang Ray A. Bressan Jiamu Du Jian-Kang Zhu |
| author_sort | Cuijun Zhang |
| collection | DOAJ |
| description | DNA methylation and H3K9 dimethylation are two linked epigenetic marks of silenced chromatin in plants that depend on the activity of CMT3/2 and SUVH4/5/6. Here the authors identify AGDP1 as an H3K9me2-binding protein required for heterochromatic non-CG DNA methylation, H3K9 dimethylation, and transcriptional silencing. |
| first_indexed | 2024-12-14T07:06:11Z |
| format | Article |
| id | doaj.art-bbf587a56361474dbd565bdccc7b4487 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T07:06:11Z |
| publishDate | 2018-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-bbf587a56361474dbd565bdccc7b44872022-12-21T23:12:12ZengNature PortfolioNature Communications2041-17232018-10-019111410.1038/s41467-018-06965-wArabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatinCuijun Zhang0Xuan Du1Kai Tang2Zhenlin Yang3Li Pan4Peipei Zhu5Jinyan Luo6Yuwei Jiang7Hui Zhang8Huafang Wan9Xingang Wang10Fengkai Wu11W. Andy Tao12Xin-Jian He13Heng Zhang14Ray A. Bressan15Jiamu Du16Jian-Kang Zhu17National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesNational Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesNational Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesNational Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesDepartment of Biochemistry, Purdue UniversityDepartment of Biochemistry, Purdue UniversityNational Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesNational Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesNational Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesDepartment of Horticulture and Landscape Architecture, Purdue UniversityDepartment of Horticulture and Landscape Architecture, Purdue UniversityDepartment of Horticulture and Landscape Architecture, Purdue UniversityDepartment of Biochemistry, Purdue UniversityNational Institute of Biological SciencesNational Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesDepartment of Horticulture and Landscape Architecture, Purdue UniversityNational Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesNational Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesDNA methylation and H3K9 dimethylation are two linked epigenetic marks of silenced chromatin in plants that depend on the activity of CMT3/2 and SUVH4/5/6. Here the authors identify AGDP1 as an H3K9me2-binding protein required for heterochromatic non-CG DNA methylation, H3K9 dimethylation, and transcriptional silencing.https://doi.org/10.1038/s41467-018-06965-w |
| spellingShingle | Cuijun Zhang Xuan Du Kai Tang Zhenlin Yang Li Pan Peipei Zhu Jinyan Luo Yuwei Jiang Hui Zhang Huafang Wan Xingang Wang Fengkai Wu W. Andy Tao Xin-Jian He Heng Zhang Ray A. Bressan Jiamu Du Jian-Kang Zhu Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin Nature Communications |
| title | Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin |
| title_full | Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin |
| title_fullStr | Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin |
| title_full_unstemmed | Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin |
| title_short | Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin |
| title_sort | arabidopsis agdp1 links h3k9me2 to dna methylation in heterochromatin |
| url | https://doi.org/10.1038/s41467-018-06965-w |
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