Tomato saponin supplementation ameliorates the development of experimental arthritis by regulating inflammatory responses
We evaluated the effect of tomato saponin, containing esculeoside A, a major saponin found in Japanese pink-colored tomato, on collagen-induced arthritis DBA/1J mice. Arthritis scores in collagen-injected mice were markedly lower by tomato saponin supplementation than that of the control throughout...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-10-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464618304857 |
| _version_ | 1818953765500223488 |
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| author | Yuko Yoshikawa Yuki Katayanagi Manatsu Kamiya Yuri Yamamoto Ryuta Fukutomi Shinjiro Imai Noriyuki Miyoshi Norio Ohashi |
| author_facet | Yuko Yoshikawa Yuki Katayanagi Manatsu Kamiya Yuri Yamamoto Ryuta Fukutomi Shinjiro Imai Noriyuki Miyoshi Norio Ohashi |
| author_sort | Yuko Yoshikawa |
| collection | DOAJ |
| description | We evaluated the effect of tomato saponin, containing esculeoside A, a major saponin found in Japanese pink-colored tomato, on collagen-induced arthritis DBA/1J mice. Arthritis scores in collagen-injected mice were markedly lower by tomato saponin supplementation than that of the control throughout the 15-days observation period. Notably, there was a significant negative correlation between the arthritis scores and serum concentrations of esculeogenin A, an aglycon of esculeoside A (R2 = 0.84, p < 0.05). Additionally, mRNA expression of pro-inflammatory cytokines in the knee joint were significantly decreased by tomato saponin. Moreover, CD38+CD45R+ splenocytes were significantly increased by tomato saponin, suggesting the shift to the type II helper T cell (Th2) response. In cultured splenocytes from DBA/1J mice, purified esculeogenin A also significantly suppressed the lipopolysaccharide-induced IL-12p40, Th1-driving component, and pro-inflammatory cytokines. Our results suggest that esculeogenin A potentially ameliorates collagen-induced arthritis by inhibiting the pro-inflammatory cytokines involved in the activation of Th1. |
| first_indexed | 2024-12-20T10:11:28Z |
| format | Article |
| id | doaj.art-bbf5b3a58b9d4fc3898bca44c28968c4 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T10:11:28Z |
| publishDate | 2018-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-bbf5b3a58b9d4fc3898bca44c28968c42022-12-21T19:44:08ZengElsevierJournal of Functional Foods1756-46462018-10-0149458464Tomato saponin supplementation ameliorates the development of experimental arthritis by regulating inflammatory responsesYuko Yoshikawa0Yuki Katayanagi1Manatsu Kamiya2Yuri Yamamoto3Ryuta Fukutomi4Shinjiro Imai5Noriyuki Miyoshi6Norio Ohashi7Department of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, JapanHealth Care Research Center, Nisshin Pharma Inc., Fujimino, Saitama, JapanDepartment of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, JapanDepartment of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, JapanHealth Care Research Center, Nisshin Pharma Inc., Fujimino, Saitama, JapanSchool of Bioscience and Biotechnology, Tokyo University of Technology, Hachioji, Tokyo, JapanDepartment of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan; Corresponding authors at: Department of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1, Yada, Suruga, Shizuoka 422-8526, Japan.Department of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan; Corresponding authors at: Department of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1, Yada, Suruga, Shizuoka 422-8526, Japan.We evaluated the effect of tomato saponin, containing esculeoside A, a major saponin found in Japanese pink-colored tomato, on collagen-induced arthritis DBA/1J mice. Arthritis scores in collagen-injected mice were markedly lower by tomato saponin supplementation than that of the control throughout the 15-days observation period. Notably, there was a significant negative correlation between the arthritis scores and serum concentrations of esculeogenin A, an aglycon of esculeoside A (R2 = 0.84, p < 0.05). Additionally, mRNA expression of pro-inflammatory cytokines in the knee joint were significantly decreased by tomato saponin. Moreover, CD38+CD45R+ splenocytes were significantly increased by tomato saponin, suggesting the shift to the type II helper T cell (Th2) response. In cultured splenocytes from DBA/1J mice, purified esculeogenin A also significantly suppressed the lipopolysaccharide-induced IL-12p40, Th1-driving component, and pro-inflammatory cytokines. Our results suggest that esculeogenin A potentially ameliorates collagen-induced arthritis by inhibiting the pro-inflammatory cytokines involved in the activation of Th1.http://www.sciencedirect.com/science/article/pii/S1756464618304857Collagen-induced arthritisEsculeogenin AInflammatory cytokinesTomato saponin |
| spellingShingle | Yuko Yoshikawa Yuki Katayanagi Manatsu Kamiya Yuri Yamamoto Ryuta Fukutomi Shinjiro Imai Noriyuki Miyoshi Norio Ohashi Tomato saponin supplementation ameliorates the development of experimental arthritis by regulating inflammatory responses Journal of Functional Foods Collagen-induced arthritis Esculeogenin A Inflammatory cytokines Tomato saponin |
| title | Tomato saponin supplementation ameliorates the development of experimental arthritis by regulating inflammatory responses |
| title_full | Tomato saponin supplementation ameliorates the development of experimental arthritis by regulating inflammatory responses |
| title_fullStr | Tomato saponin supplementation ameliorates the development of experimental arthritis by regulating inflammatory responses |
| title_full_unstemmed | Tomato saponin supplementation ameliorates the development of experimental arthritis by regulating inflammatory responses |
| title_short | Tomato saponin supplementation ameliorates the development of experimental arthritis by regulating inflammatory responses |
| title_sort | tomato saponin supplementation ameliorates the development of experimental arthritis by regulating inflammatory responses |
| topic | Collagen-induced arthritis Esculeogenin A Inflammatory cytokines Tomato saponin |
| url | http://www.sciencedirect.com/science/article/pii/S1756464618304857 |
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