Main Cations and Cellular Biology of Traumatic Spinal Cord Injury
Traumatic spinal cord injury is a life-changing condition with a significant socio-economic impact on patients, their relatives, their caregivers, and even the community. Despite considerable medical advances, there is still a lack of options for the effective treatment of these patients. The major...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/16/2503 |
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| author | Constantin Munteanu Mariana Rotariu Marius Turnea Anca Mirela Ionescu Cristina Popescu Aura Spinu Elena Valentina Ionescu Carmen Oprea Roxana Elena Țucmeanu Ligia Gabriela Tătăranu Sînziana Calina Silișteanu Gelu Onose |
| author_facet | Constantin Munteanu Mariana Rotariu Marius Turnea Anca Mirela Ionescu Cristina Popescu Aura Spinu Elena Valentina Ionescu Carmen Oprea Roxana Elena Țucmeanu Ligia Gabriela Tătăranu Sînziana Calina Silișteanu Gelu Onose |
| author_sort | Constantin Munteanu |
| collection | DOAJ |
| description | Traumatic spinal cord injury is a life-changing condition with a significant socio-economic impact on patients, their relatives, their caregivers, and even the community. Despite considerable medical advances, there is still a lack of options for the effective treatment of these patients. The major complexity and significant disabling potential of the pathophysiology that spinal cord trauma triggers are the main factors that have led to incremental scientific research on this topic, including trying to describe the molecular and cellular mechanisms that regulate spinal cord repair and regeneration. Scientists have identified various practical approaches to promote cell growth and survival, remyelination, and neuroplasticity in this part of the central nervous system. This review focuses on specific detailed aspects of the involvement of cations in the cell biology of such pathology and on the possibility of repairing damaged spinal cord tissue. In this context, the cellular biology of sodium, potassium, lithium, calcium, and magnesium is essential for understanding the related pathophysiology and also the possibilities to counteract the harmful effects of traumatic events. Lithium, sodium, potassium—monovalent cations—and calcium and magnesium—bivalent cations—can influence many protein–protein interactions, gene transcription, ion channel functions, cellular energy processes—phosphorylation, oxidation—inflammation, etc. For data systematization and synthesis, we used the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) methodology, trying to make, as far as possible, some order in seeing the “big forest” instead of “trees”. Although we would have expected a large number of articles to address the topic, we were still surprised to find only 51 unique articles after removing duplicates from the 207 articles initially identified. Our article integrates data on many biochemical processes influenced by cations at the molecular level to understand the real possibilities of therapeutic intervention—which must maintain a very narrow balance in cell ion concentrations. Multimolecular, multi-cellular: neuronal cells, glial cells, non-neuronal cells, but also multi-ionic interactions play an important role in the balance between neuro-degenerative pathophysiological processes and the development of effective neuroprotective strategies. This article emphasizes the need for studying cation dynamics as an important future direction. |
| first_indexed | 2024-03-09T04:37:16Z |
| format | Article |
| id | doaj.art-bbf666bcf0c14b1095457dbc3555a4a4 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T04:37:16Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-bbf666bcf0c14b1095457dbc3555a4a42023-12-03T13:26:57ZengMDPI AGCells2073-44092022-08-011116250310.3390/cells11162503Main Cations and Cellular Biology of Traumatic Spinal Cord InjuryConstantin Munteanu0Mariana Rotariu1Marius Turnea2Anca Mirela Ionescu3Cristina Popescu4Aura Spinu5Elena Valentina Ionescu6Carmen Oprea7Roxana Elena Țucmeanu8Ligia Gabriela Tătăranu9Sînziana Calina Silișteanu10Gelu Onose11Faculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa” Iași, 700454 Iași, RomaniaFaculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa” Iași, 700454 Iași, RomaniaFaculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa” Iași, 700454 Iași, RomaniaFaculty of Medicine, University of Medicine and Pharmacy “Carol Davila”, 020022 Bucharest, RomaniaNeuromuscular Rehabilitation Division, Teaching Emergency Hospital “Bagdasar-Arseni”, 041915 Bucharest, RomaniaNeuromuscular Rehabilitation Division, Teaching Emergency Hospital “Bagdasar-Arseni”, 041915 Bucharest, RomaniaFaculty of Medicine, Ovidius University of Constanta, 900470 Constanta, RomaniaFaculty of Medicine, Ovidius University of Constanta, 900470 Constanta, RomaniaFaculty of Medicine, Ovidius University of Constanta, 900470 Constanta, RomaniaNeuromuscular Rehabilitation Division, Teaching Emergency Hospital “Bagdasar-Arseni”, 041915 Bucharest, RomaniaFaculty of Medicine and Biological Sciences, “Stefan cel Mare” University of Suceava, 720229 Suceava, RomaniaNeuromuscular Rehabilitation Division, Teaching Emergency Hospital “Bagdasar-Arseni”, 041915 Bucharest, RomaniaTraumatic spinal cord injury is a life-changing condition with a significant socio-economic impact on patients, their relatives, their caregivers, and even the community. Despite considerable medical advances, there is still a lack of options for the effective treatment of these patients. The major complexity and significant disabling potential of the pathophysiology that spinal cord trauma triggers are the main factors that have led to incremental scientific research on this topic, including trying to describe the molecular and cellular mechanisms that regulate spinal cord repair and regeneration. Scientists have identified various practical approaches to promote cell growth and survival, remyelination, and neuroplasticity in this part of the central nervous system. This review focuses on specific detailed aspects of the involvement of cations in the cell biology of such pathology and on the possibility of repairing damaged spinal cord tissue. In this context, the cellular biology of sodium, potassium, lithium, calcium, and magnesium is essential for understanding the related pathophysiology and also the possibilities to counteract the harmful effects of traumatic events. Lithium, sodium, potassium—monovalent cations—and calcium and magnesium—bivalent cations—can influence many protein–protein interactions, gene transcription, ion channel functions, cellular energy processes—phosphorylation, oxidation—inflammation, etc. For data systematization and synthesis, we used the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) methodology, trying to make, as far as possible, some order in seeing the “big forest” instead of “trees”. Although we would have expected a large number of articles to address the topic, we were still surprised to find only 51 unique articles after removing duplicates from the 207 articles initially identified. Our article integrates data on many biochemical processes influenced by cations at the molecular level to understand the real possibilities of therapeutic intervention—which must maintain a very narrow balance in cell ion concentrations. Multimolecular, multi-cellular: neuronal cells, glial cells, non-neuronal cells, but also multi-ionic interactions play an important role in the balance between neuro-degenerative pathophysiological processes and the development of effective neuroprotective strategies. This article emphasizes the need for studying cation dynamics as an important future direction.https://www.mdpi.com/2073-4409/11/16/2503systematic reviewcationssodiumpotassiumlithiumcalcium |
| spellingShingle | Constantin Munteanu Mariana Rotariu Marius Turnea Anca Mirela Ionescu Cristina Popescu Aura Spinu Elena Valentina Ionescu Carmen Oprea Roxana Elena Țucmeanu Ligia Gabriela Tătăranu Sînziana Calina Silișteanu Gelu Onose Main Cations and Cellular Biology of Traumatic Spinal Cord Injury Cells systematic review cations sodium potassium lithium calcium |
| title | Main Cations and Cellular Biology of Traumatic Spinal Cord Injury |
| title_full | Main Cations and Cellular Biology of Traumatic Spinal Cord Injury |
| title_fullStr | Main Cations and Cellular Biology of Traumatic Spinal Cord Injury |
| title_full_unstemmed | Main Cations and Cellular Biology of Traumatic Spinal Cord Injury |
| title_short | Main Cations and Cellular Biology of Traumatic Spinal Cord Injury |
| title_sort | main cations and cellular biology of traumatic spinal cord injury |
| topic | systematic review cations sodium potassium lithium calcium |
| url | https://www.mdpi.com/2073-4409/11/16/2503 |
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