Intraoperative MRI-derived volumetric ablation margins and initial correlation with local outcome after MRI-guided cryoablation of renal tumors
Abstract Purpose To assess volumetric ablation margins derived from intraoperative pre- and post-ablation MRI after magnetic resonance imaging (MRI)-guided percutaneous cryoablation of renal tumors and explore its correlation with local treatment success. Methods Retrospective analysis was performed...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Cancer Imaging |
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| Online Access: | https://doi.org/10.1186/s40644-023-00546-x |
| _version_ | 1797853606577176576 |
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| author | Nienke S. de Jager Tim J. van Oostenbrugge Torben Pätz Sjoerd F. M. Jenniskens Jurgen J. Fütterer Johan F. Langenhuijsen Christiaan G. Overduin |
| author_facet | Nienke S. de Jager Tim J. van Oostenbrugge Torben Pätz Sjoerd F. M. Jenniskens Jurgen J. Fütterer Johan F. Langenhuijsen Christiaan G. Overduin |
| author_sort | Nienke S. de Jager |
| collection | DOAJ |
| description | Abstract Purpose To assess volumetric ablation margins derived from intraoperative pre- and post-ablation MRI after magnetic resonance imaging (MRI)-guided percutaneous cryoablation of renal tumors and explore its correlation with local treatment success. Methods Retrospective analysis was performed on 30 patients (mean age 69y) who underwent percutaneous MRI-guided cryoablation between May 2014 and May 2020 for 32 renal tumors (size: 1.6–5.1 cm). Tumor and ice-ball volumes were segmented on intraprocedural pre- and post-ablation MR images using Software Assistant for Interventional Radiology (SAFIR) software. After MRI-MRI co-registration, the software automatically quantified the minimal treatment margin (MTM),defined as the smallest 3D distance between the tumor and ice-ball surface. Local tumor progression (LTP) after cryoablation was assessed on follow-up imaging. Results Median follow-up was 16 months (range: 1–58). Local control after cryoablation was achieved in 26 cases (81%) while LTP occurred in 6 (19%). The intended MTM of ≥5 mm was achieved in 3/32 (9%) cases. Median MTM was significantly smaller for cases with (− 7 mm; IQR:-10 to − 5) vs. without LTP (3 mm; IQR:2 to 4) (P < .001). All cases of LTP had a negative MTM. All negative treatment margins occurred in tumors > 3 cm. Conclusions Determination of volumetric ablation margins from intraoperative MRI was feasible and may be useful in predicting local outcome after MRI-guided renal cryoablation. In our preliminary data, an intraoperative MRI-derived minimal margin extending at least 1 mm beyond the MRI-visible tumor led to local control and this was more difficult to achieve in tumors > 3 cm. Ultimately, online margin analysis may be a valuable tool to intraoperatively assess therapy success, but larger prospective studies are needed to establish a reliable threshold for clinical use. |
| first_indexed | 2024-04-09T19:53:26Z |
| format | Article |
| id | doaj.art-bbfa554804824086be560fe8b75c299f |
| institution | Directory Open Access Journal |
| issn | 1470-7330 |
| language | English |
| last_indexed | 2024-04-09T19:53:26Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Imaging |
| spelling | doaj.art-bbfa554804824086be560fe8b75c299f2023-04-03T05:39:07ZengBMCCancer Imaging1470-73302023-03-0123111010.1186/s40644-023-00546-xIntraoperative MRI-derived volumetric ablation margins and initial correlation with local outcome after MRI-guided cryoablation of renal tumorsNienke S. de Jager0Tim J. van Oostenbrugge1Torben Pätz2Sjoerd F. M. Jenniskens3Jurgen J. Fütterer4Johan F. Langenhuijsen5Christiaan G. Overduin6Department of Medical Imaging, Radboud University Medical CenterDepartment of Urology, Radboud University Medical CenterFraunhofer Institute for Digital MedicineDepartment of Medical Imaging, Radboud University Medical CenterDepartment of Medical Imaging, Radboud University Medical CenterDepartment of Urology, Radboud University Medical CenterDepartment of Medical Imaging, Radboud University Medical CenterAbstract Purpose To assess volumetric ablation margins derived from intraoperative pre- and post-ablation MRI after magnetic resonance imaging (MRI)-guided percutaneous cryoablation of renal tumors and explore its correlation with local treatment success. Methods Retrospective analysis was performed on 30 patients (mean age 69y) who underwent percutaneous MRI-guided cryoablation between May 2014 and May 2020 for 32 renal tumors (size: 1.6–5.1 cm). Tumor and ice-ball volumes were segmented on intraprocedural pre- and post-ablation MR images using Software Assistant for Interventional Radiology (SAFIR) software. After MRI-MRI co-registration, the software automatically quantified the minimal treatment margin (MTM),defined as the smallest 3D distance between the tumor and ice-ball surface. Local tumor progression (LTP) after cryoablation was assessed on follow-up imaging. Results Median follow-up was 16 months (range: 1–58). Local control after cryoablation was achieved in 26 cases (81%) while LTP occurred in 6 (19%). The intended MTM of ≥5 mm was achieved in 3/32 (9%) cases. Median MTM was significantly smaller for cases with (− 7 mm; IQR:-10 to − 5) vs. without LTP (3 mm; IQR:2 to 4) (P < .001). All cases of LTP had a negative MTM. All negative treatment margins occurred in tumors > 3 cm. Conclusions Determination of volumetric ablation margins from intraoperative MRI was feasible and may be useful in predicting local outcome after MRI-guided renal cryoablation. In our preliminary data, an intraoperative MRI-derived minimal margin extending at least 1 mm beyond the MRI-visible tumor led to local control and this was more difficult to achieve in tumors > 3 cm. Ultimately, online margin analysis may be a valuable tool to intraoperatively assess therapy success, but larger prospective studies are needed to establish a reliable threshold for clinical use.https://doi.org/10.1186/s40644-023-00546-xRenal tumorPercutaneous cryoablationMRITreatment marginLocal recurrence |
| spellingShingle | Nienke S. de Jager Tim J. van Oostenbrugge Torben Pätz Sjoerd F. M. Jenniskens Jurgen J. Fütterer Johan F. Langenhuijsen Christiaan G. Overduin Intraoperative MRI-derived volumetric ablation margins and initial correlation with local outcome after MRI-guided cryoablation of renal tumors Cancer Imaging Renal tumor Percutaneous cryoablation MRI Treatment margin Local recurrence |
| title | Intraoperative MRI-derived volumetric ablation margins and initial correlation with local outcome after MRI-guided cryoablation of renal tumors |
| title_full | Intraoperative MRI-derived volumetric ablation margins and initial correlation with local outcome after MRI-guided cryoablation of renal tumors |
| title_fullStr | Intraoperative MRI-derived volumetric ablation margins and initial correlation with local outcome after MRI-guided cryoablation of renal tumors |
| title_full_unstemmed | Intraoperative MRI-derived volumetric ablation margins and initial correlation with local outcome after MRI-guided cryoablation of renal tumors |
| title_short | Intraoperative MRI-derived volumetric ablation margins and initial correlation with local outcome after MRI-guided cryoablation of renal tumors |
| title_sort | intraoperative mri derived volumetric ablation margins and initial correlation with local outcome after mri guided cryoablation of renal tumors |
| topic | Renal tumor Percutaneous cryoablation MRI Treatment margin Local recurrence |
| url | https://doi.org/10.1186/s40644-023-00546-x |
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