Cardiac regeneration: 20 years of development and update in zebrafish and mouse
Cardiovascular diseases are one of the leading causes of death globally. The primary pathological mechanism in myocardial infarction and heart failure is irreversible cardiomyocyte loss. The conventional knowledge is that mammals have a transient cardiac regenerative potential shortly after birth, b...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | All Life |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/26895293.2024.2308904 |
| _version_ | 1797303128098340864 |
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| author | Lekun Gui Lijun Jin Huangjun Liu |
| author_facet | Lekun Gui Lijun Jin Huangjun Liu |
| author_sort | Lekun Gui |
| collection | DOAJ |
| description | Cardiovascular diseases are one of the leading causes of death globally. The primary pathological mechanism in myocardial infarction and heart failure is irreversible cardiomyocyte loss. The conventional knowledge is that mammals have a transient cardiac regenerative potential shortly after birth, but adult cardiomyocytes, as terminally differentiated cells, cannot regenerate. In contrast, some lower vertebrates, such as zebrafish, regenerate cardiac muscle throughout their lifetime. Zebrafish are extremely sensitive to cardiac injury and, within a short period, stimulate the proliferation of cardiomyocytes in numbers that fully regenerate to pre-injury levels; meanwhile, the initial scarring is gradually absorbed until there is little or no visible sign of fibrosis in the regenerating myocardium. The newborn mouse heart has the same remarkable regenerative potential before birth as one week after cardiac injury. The complex process of regeneration restores tissue structure through a series of cascade events, a coordinated process of cell proliferation, differentiation and dedifferentiation, and rearrangement of tissue morphogenesis. Understanding the ontogeny and development of cardiac regeneration and the molecular mechanisms of cardiac regeneration in zebrafish and mice is the cornerstone of regenerative biology and provides clues to investigate the cardiac repair process in adult mammals, resulting in extensive scarring rather than cardiomyocyte regeneration. |
| first_indexed | 2024-03-07T23:47:31Z |
| format | Article |
| id | doaj.art-bbfb04f4b66f4635b179b6e67b763e84 |
| institution | Directory Open Access Journal |
| issn | 2689-5307 |
| language | English |
| last_indexed | 2024-03-07T23:47:31Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | All Life |
| spelling | doaj.art-bbfb04f4b66f4635b179b6e67b763e842024-02-19T09:32:28ZengTaylor & Francis GroupAll Life2689-53072024-12-0117110.1080/26895293.2024.23089042308904Cardiac regeneration: 20 years of development and update in zebrafish and mouseLekun Gui0Lijun Jin1Huangjun Liu2The First Affiliated Hospital of Yangtze UniversityThe First Affiliated Hospital of Yangtze UniversityThe First Affiliated Hospital of Yangtze UniversityCardiovascular diseases are one of the leading causes of death globally. The primary pathological mechanism in myocardial infarction and heart failure is irreversible cardiomyocyte loss. The conventional knowledge is that mammals have a transient cardiac regenerative potential shortly after birth, but adult cardiomyocytes, as terminally differentiated cells, cannot regenerate. In contrast, some lower vertebrates, such as zebrafish, regenerate cardiac muscle throughout their lifetime. Zebrafish are extremely sensitive to cardiac injury and, within a short period, stimulate the proliferation of cardiomyocytes in numbers that fully regenerate to pre-injury levels; meanwhile, the initial scarring is gradually absorbed until there is little or no visible sign of fibrosis in the regenerating myocardium. The newborn mouse heart has the same remarkable regenerative potential before birth as one week after cardiac injury. The complex process of regeneration restores tissue structure through a series of cascade events, a coordinated process of cell proliferation, differentiation and dedifferentiation, and rearrangement of tissue morphogenesis. Understanding the ontogeny and development of cardiac regeneration and the molecular mechanisms of cardiac regeneration in zebrafish and mice is the cornerstone of regenerative biology and provides clues to investigate the cardiac repair process in adult mammals, resulting in extensive scarring rather than cardiomyocyte regeneration.http://dx.doi.org/10.1080/26895293.2024.2308904cardiac regenerationzebrafishmousemyocardial infarctionheart failurecell proliferation |
| spellingShingle | Lekun Gui Lijun Jin Huangjun Liu Cardiac regeneration: 20 years of development and update in zebrafish and mouse All Life cardiac regeneration zebrafish mouse myocardial infarction heart failure cell proliferation |
| title | Cardiac regeneration: 20 years of development and update in zebrafish and mouse |
| title_full | Cardiac regeneration: 20 years of development and update in zebrafish and mouse |
| title_fullStr | Cardiac regeneration: 20 years of development and update in zebrafish and mouse |
| title_full_unstemmed | Cardiac regeneration: 20 years of development and update in zebrafish and mouse |
| title_short | Cardiac regeneration: 20 years of development and update in zebrafish and mouse |
| title_sort | cardiac regeneration 20 years of development and update in zebrafish and mouse |
| topic | cardiac regeneration zebrafish mouse myocardial infarction heart failure cell proliferation |
| url | http://dx.doi.org/10.1080/26895293.2024.2308904 |
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