Small colony variants phenotype and biofilm formation: Implication in persistent Staphylococcus aureus infection
Staphylococcus aureus survival strategy for persistence can be attributed to their metabolic versatility under unfavorable conditions by switching to small colony variants (SCVs) phenotype and forming biofilm; these attributes contribute to their widespread dissemination, difficulty to detect in rou...
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| Format: | Article |
| Language: | English |
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Zagazig University, Faculty of Medicine
2022-08-01
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| Series: | Microbes and Infectious Diseases |
| Subjects: | |
| Online Access: | https://mid.journals.ekb.eg/article_207846_93a47d69853be457dbab11c3b6feb455.pdf |
| _version_ | 1811181194855841792 |
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| author | Haruna Adamu Abdulrahman Kasim Shitu Abdullahi Patrick Shaibu |
| author_facet | Haruna Adamu Abdulrahman Kasim Shitu Abdullahi Patrick Shaibu |
| author_sort | Haruna Adamu |
| collection | DOAJ |
| description | Staphylococcus aureus survival strategy for persistence can be attributed to their metabolic versatility under unfavorable conditions by switching to small colony variants (SCVs) phenotype and forming biofilm; these attributes contribute to their widespread dissemination, difficulty to detect in routine microbiological screening and challenging eradication particularly in clinical setting, resulting to persistent nature of their infections. The SCVs can survive intracellularly, misinterpreted as coagulase negative Staphylococcus aureus (CoNS) and down regulate some virulence factors. Biofilm formation provides protection against antibiotics and immune responses; the matrix serve as a physical barrier and transfer of resistant determinant via conjugation occur among the encased bacteria because of their proximity. Thus; SCVs and biofilm aid evasion of antibiotics and immune response resulting to persistent infection. Therefore, understanding the process associated with the ability of bacteria to persist could significantly aid in the development of a better therapeutic options that will ultimately reduce the risk of morbidity and mortality. |
| first_indexed | 2024-04-11T09:14:14Z |
| format | Article |
| id | doaj.art-bbfb2945966247cb8ddde112c3f8e85d |
| institution | Directory Open Access Journal |
| issn | 2682-4132 2682-4140 |
| language | English |
| last_indexed | 2024-04-11T09:14:14Z |
| publishDate | 2022-08-01 |
| publisher | Zagazig University, Faculty of Medicine |
| record_format | Article |
| series | Microbes and Infectious Diseases |
| spelling | doaj.art-bbfb2945966247cb8ddde112c3f8e85d2022-12-22T04:32:24ZengZagazig University, Faculty of MedicineMicrobes and Infectious Diseases2682-41322682-41402022-08-013366867410.21608/mid.2021.103244.1205207846Small colony variants phenotype and biofilm formation: Implication in persistent Staphylococcus aureus infectionHaruna Adamu0Abdulrahman Kasim1Shitu Abdullahi2Patrick Shaibu3Department of Pharmaceutical Microbiology, Ahmadu Bello University Zaria, Kaduna State, NigeriaDepartment of Pharmaceutical Microbiology, Ahmadu Bello University Zaria, Kaduna State, NigeriaDepartment of Pharmaceutical Microbiology, Ahmadu Bello University Zaria, Kaduna State, NigeriaDepartment of Nursing, College of Nursing and Midwifery, Gombe State, NigeriaStaphylococcus aureus survival strategy for persistence can be attributed to their metabolic versatility under unfavorable conditions by switching to small colony variants (SCVs) phenotype and forming biofilm; these attributes contribute to their widespread dissemination, difficulty to detect in routine microbiological screening and challenging eradication particularly in clinical setting, resulting to persistent nature of their infections. The SCVs can survive intracellularly, misinterpreted as coagulase negative Staphylococcus aureus (CoNS) and down regulate some virulence factors. Biofilm formation provides protection against antibiotics and immune responses; the matrix serve as a physical barrier and transfer of resistant determinant via conjugation occur among the encased bacteria because of their proximity. Thus; SCVs and biofilm aid evasion of antibiotics and immune response resulting to persistent infection. Therefore, understanding the process associated with the ability of bacteria to persist could significantly aid in the development of a better therapeutic options that will ultimately reduce the risk of morbidity and mortality.https://mid.journals.ekb.eg/article_207846_93a47d69853be457dbab11c3b6feb455.pdfpersistent infectionsmall colony variants (scvs)biofilm formationstaphylococcus aureus |
| spellingShingle | Haruna Adamu Abdulrahman Kasim Shitu Abdullahi Patrick Shaibu Small colony variants phenotype and biofilm formation: Implication in persistent Staphylococcus aureus infection Microbes and Infectious Diseases persistent infection small colony variants (scvs) biofilm formation staphylococcus aureus |
| title | Small colony variants phenotype and biofilm formation: Implication in persistent Staphylococcus aureus infection |
| title_full | Small colony variants phenotype and biofilm formation: Implication in persistent Staphylococcus aureus infection |
| title_fullStr | Small colony variants phenotype and biofilm formation: Implication in persistent Staphylococcus aureus infection |
| title_full_unstemmed | Small colony variants phenotype and biofilm formation: Implication in persistent Staphylococcus aureus infection |
| title_short | Small colony variants phenotype and biofilm formation: Implication in persistent Staphylococcus aureus infection |
| title_sort | small colony variants phenotype and biofilm formation implication in persistent staphylococcus aureus infection |
| topic | persistent infection small colony variants (scvs) biofilm formation staphylococcus aureus |
| url | https://mid.journals.ekb.eg/article_207846_93a47d69853be457dbab11c3b6feb455.pdf |
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