Impact of Autophagy of Innate Immune Cells on Inflammatory Bowel Disease
Autophagy, an intracellular degradation mechanism, has many immunological functions and is a constitutive process necessary for maintaining cellular homeostasis and organ structure. One of the functions of autophagy is to control the innate immune response. Many studies conducted in recent years hav...
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| Format: | Article |
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MDPI AG
2018-12-01
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| Series: | Cells |
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| Online Access: | http://www.mdpi.com/2073-4409/8/1/7 |
| _version_ | 1797708079749398528 |
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| author | Tomoya Iida Yoshihiro Yokoyama Kohei Wagatsuma Daisuke Hirayama Hiroshi Nakase |
| author_facet | Tomoya Iida Yoshihiro Yokoyama Kohei Wagatsuma Daisuke Hirayama Hiroshi Nakase |
| author_sort | Tomoya Iida |
| collection | DOAJ |
| description | Autophagy, an intracellular degradation mechanism, has many immunological functions and is a constitutive process necessary for maintaining cellular homeostasis and organ structure. One of the functions of autophagy is to control the innate immune response. Many studies conducted in recent years have revealed the contribution of autophagy to the innate immune response, and relationships between this process and various diseases have been reported. Inflammatory bowel disease is an intractable disorder with unknown etiology; however, immunological abnormalities in the intestines are known to be involved in the pathology of inflammatory bowel disease, as is dysfunction of autophagy. In Crohn’s disease, many associations with autophagy-related genes, such as ATG16L1, IRGM, NOD2, and others, have been reported. Abnormalities in the ATG16L1 gene, in particular, have been reported to cause autophagic dysfunction, resulting in enhanced production of inflammatory cytokines by macrophages as well as abnormal function of Paneth cells, which are important in intestinal innate immunity. In this review, we provide an overview of the autophagy mechanism in innate immune cells in inflammatory bowel disease. |
| first_indexed | 2024-03-12T06:17:05Z |
| format | Article |
| id | doaj.art-bbfcdc3c22514acaa635894f2b84e4d0 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T06:17:05Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-bbfcdc3c22514acaa635894f2b84e4d02023-09-03T02:33:03ZengMDPI AGCells2073-44092018-12-0181710.3390/cells8010007cells8010007Impact of Autophagy of Innate Immune Cells on Inflammatory Bowel DiseaseTomoya Iida0Yoshihiro Yokoyama1Kohei Wagatsuma2Daisuke Hirayama3Hiroshi Nakase4Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo 060-8543, JapanDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo 060-8543, JapanDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo 060-8543, JapanDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo 060-8543, JapanDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo 060-8543, JapanAutophagy, an intracellular degradation mechanism, has many immunological functions and is a constitutive process necessary for maintaining cellular homeostasis and organ structure. One of the functions of autophagy is to control the innate immune response. Many studies conducted in recent years have revealed the contribution of autophagy to the innate immune response, and relationships between this process and various diseases have been reported. Inflammatory bowel disease is an intractable disorder with unknown etiology; however, immunological abnormalities in the intestines are known to be involved in the pathology of inflammatory bowel disease, as is dysfunction of autophagy. In Crohn’s disease, many associations with autophagy-related genes, such as ATG16L1, IRGM, NOD2, and others, have been reported. Abnormalities in the ATG16L1 gene, in particular, have been reported to cause autophagic dysfunction, resulting in enhanced production of inflammatory cytokines by macrophages as well as abnormal function of Paneth cells, which are important in intestinal innate immunity. In this review, we provide an overview of the autophagy mechanism in innate immune cells in inflammatory bowel disease.http://www.mdpi.com/2073-4409/8/1/7autophagyinnate immunityimmune cellinflammasomePaneth cellinflammatory bowel diseaseCrohn’s disease |
| spellingShingle | Tomoya Iida Yoshihiro Yokoyama Kohei Wagatsuma Daisuke Hirayama Hiroshi Nakase Impact of Autophagy of Innate Immune Cells on Inflammatory Bowel Disease Cells autophagy innate immunity immune cell inflammasome Paneth cell inflammatory bowel disease Crohn’s disease |
| title | Impact of Autophagy of Innate Immune Cells on Inflammatory Bowel Disease |
| title_full | Impact of Autophagy of Innate Immune Cells on Inflammatory Bowel Disease |
| title_fullStr | Impact of Autophagy of Innate Immune Cells on Inflammatory Bowel Disease |
| title_full_unstemmed | Impact of Autophagy of Innate Immune Cells on Inflammatory Bowel Disease |
| title_short | Impact of Autophagy of Innate Immune Cells on Inflammatory Bowel Disease |
| title_sort | impact of autophagy of innate immune cells on inflammatory bowel disease |
| topic | autophagy innate immunity immune cell inflammasome Paneth cell inflammatory bowel disease Crohn’s disease |
| url | http://www.mdpi.com/2073-4409/8/1/7 |
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