<b>Spectral characterizations and antibacterial effect of 2-(5-R-1<i>H</i>-benzimidazol-2-yl)-4-methyl/bromo-phenols and some metal complexes</b>
2-(5-H/Cl/Me/NO<sub>2</sub>-1H-benzimidazol-2-yl)-4-Me/Br-phenols (HL<sub>1</sub>–HL<sub>5</sub>) were synthesized. HL<sub>1</sub> complexes with Cu(NO<sub>3</sub>)<sub>2</sub>, AgNO<sub>3</sub>, Zn(ClO<sub>4&l...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Chemical Society of Ethiopia
2010-06-01
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| Series: | Bulletin of the Chemical Society of Ethiopia |
| Subjects: | |
| Online Access: | http://ajol.info/index.php/bcse/article/view/60686 |
| Summary: | 2-(5-H/Cl/Me/NO<sub>2</sub>-1H-benzimidazol-2-yl)-4-Me/Br-phenols (HL<sub>1</sub>–HL<sub>5</sub>) were synthesized. HL<sub>1</sub> complexes with Cu(NO<sub>3</sub>)<sub>2</sub>, AgNO<sub>3</sub>, Zn(ClO<sub>4</sub>)<sub>2</sub> and; HL<sub>4</sub>, HL<sub>5</sub> complexes with Zn(ClO<sub>4</sub>)<sub>2</sub> were prepared. The structures of the compounds were confirmed on the basis of elemental analysis, molar conductivity, magnetic moment, FT-IR, <sup>1</sup>H- and <sup>13</sup>C-NMR. Antibacterial activity of the ligands and the complexes were evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimal inhibitory concentration (MIC) dilution method, against nine bacteria, and the results were compared with penicillin–G and oxytetracycline. While HL<sub>1</sub> ligand has considerable antibacterial activity on <i>B. cereus</i> only; it’s Ag(I) complex show antibacterial effect toward almost all the bacteria. It is highly interesting that HL<sub>5</sub> and [Zn(HL<sub>5</sub>)(L<sub>5</sub>)]ClO<sub>4</sub> exhibit considerable high antibacterial activity toward <i>K. pneumoniae</i>, <i>B. cereus</i>, <i>S. epidermidis</i> and <i>B. subtilis</i>. |
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| ISSN: | 1011-3924 1726-801X |