<b>Spectral characterizations and antibacterial effect of 2-(5-R-1<i>H</i>-benzimidazol-2-yl)-4-methyl/bromo-phenols and some metal complexes</b>
2-(5-H/Cl/Me/NO<sub>2</sub>-1H-benzimidazol-2-yl)-4-Me/Br-phenols (HL<sub>1</sub>–HL<sub>5</sub>) were synthesized. HL<sub>1</sub> complexes with Cu(NO<sub>3</sub>)<sub>2</sub>, AgNO<sub>3</sub>, Zn(ClO<sub>4&l...
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| Format: | Article |
| Language: | English |
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Chemical Society of Ethiopia
2010-06-01
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| Series: | Bulletin of the Chemical Society of Ethiopia |
| Subjects: | |
| Online Access: | http://ajol.info/index.php/bcse/article/view/60686 |
| _version_ | 1818546460786950144 |
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| author | Seyyal Ak N. Yakut Özgür A. Funda Bagcigil Serkan Ikiz Aydin Tavman |
| author_facet | Seyyal Ak N. Yakut Özgür A. Funda Bagcigil Serkan Ikiz Aydin Tavman |
| author_sort | Seyyal Ak |
| collection | DOAJ |
| description | 2-(5-H/Cl/Me/NO<sub>2</sub>-1H-benzimidazol-2-yl)-4-Me/Br-phenols (HL<sub>1</sub>–HL<sub>5</sub>) were synthesized. HL<sub>1</sub> complexes with Cu(NO<sub>3</sub>)<sub>2</sub>, AgNO<sub>3</sub>, Zn(ClO<sub>4</sub>)<sub>2</sub> and; HL<sub>4</sub>, HL<sub>5</sub> complexes with Zn(ClO<sub>4</sub>)<sub>2</sub> were prepared. The structures of the compounds were confirmed on the basis of elemental analysis, molar conductivity, magnetic moment, FT-IR, <sup>1</sup>H- and <sup>13</sup>C-NMR. Antibacterial activity of the ligands and the complexes were evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimal inhibitory concentration (MIC) dilution method, against nine bacteria, and the results were compared with penicillin–G and oxytetracycline. While HL<sub>1</sub> ligand has considerable antibacterial activity on <i>B. cereus</i> only; it’s Ag(I) complex show antibacterial effect toward almost all the bacteria. It is highly interesting that HL<sub>5</sub> and [Zn(HL<sub>5</sub>)(L<sub>5</sub>)]ClO<sub>4</sub> exhibit considerable high antibacterial activity toward <i>K. pneumoniae</i>, <i>B. cereus</i>, <i>S. epidermidis</i> and <i>B. subtilis</i>. |
| first_indexed | 2024-12-12T07:53:31Z |
| format | Article |
| id | doaj.art-bbfd309adeb84374bd0db4de967aea04 |
| institution | Directory Open Access Journal |
| issn | 1011-3924 1726-801X |
| language | English |
| last_indexed | 2024-12-12T07:53:31Z |
| publishDate | 2010-06-01 |
| publisher | Chemical Society of Ethiopia |
| record_format | Article |
| series | Bulletin of the Chemical Society of Ethiopia |
| spelling | doaj.art-bbfd309adeb84374bd0db4de967aea042022-12-22T00:32:22ZengChemical Society of EthiopiaBulletin of the Chemical Society of Ethiopia1011-39241726-801X2010-06-01243391400<b>Spectral characterizations and antibacterial effect of 2-(5-R-1<i>H</i>-benzimidazol-2-yl)-4-methyl/bromo-phenols and some metal complexes</b>Seyyal AkN. Yakut ÖzgürA. Funda BagcigilSerkan IkizAydin Tavman2-(5-H/Cl/Me/NO<sub>2</sub>-1H-benzimidazol-2-yl)-4-Me/Br-phenols (HL<sub>1</sub>–HL<sub>5</sub>) were synthesized. HL<sub>1</sub> complexes with Cu(NO<sub>3</sub>)<sub>2</sub>, AgNO<sub>3</sub>, Zn(ClO<sub>4</sub>)<sub>2</sub> and; HL<sub>4</sub>, HL<sub>5</sub> complexes with Zn(ClO<sub>4</sub>)<sub>2</sub> were prepared. The structures of the compounds were confirmed on the basis of elemental analysis, molar conductivity, magnetic moment, FT-IR, <sup>1</sup>H- and <sup>13</sup>C-NMR. Antibacterial activity of the ligands and the complexes were evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimal inhibitory concentration (MIC) dilution method, against nine bacteria, and the results were compared with penicillin–G and oxytetracycline. While HL<sub>1</sub> ligand has considerable antibacterial activity on <i>B. cereus</i> only; it’s Ag(I) complex show antibacterial effect toward almost all the bacteria. It is highly interesting that HL<sub>5</sub> and [Zn(HL<sub>5</sub>)(L<sub>5</sub>)]ClO<sub>4</sub> exhibit considerable high antibacterial activity toward <i>K. pneumoniae</i>, <i>B. cereus</i>, <i>S. epidermidis</i> and <i>B. subtilis</i>.http://ajol.info/index.php/bcse/article/view/60686BenzimidazolePhenolMetal complexesAntibacterial activity |
| spellingShingle | Seyyal Ak N. Yakut Özgür A. Funda Bagcigil Serkan Ikiz Aydin Tavman <b>Spectral characterizations and antibacterial effect of 2-(5-R-1<i>H</i>-benzimidazol-2-yl)-4-methyl/bromo-phenols and some metal complexes</b> Bulletin of the Chemical Society of Ethiopia Benzimidazole Phenol Metal complexes Antibacterial activity |
| title | <b>Spectral characterizations and antibacterial effect of 2-(5-R-1<i>H</i>-benzimidazol-2-yl)-4-methyl/bromo-phenols and some metal complexes</b> |
| title_full | <b>Spectral characterizations and antibacterial effect of 2-(5-R-1<i>H</i>-benzimidazol-2-yl)-4-methyl/bromo-phenols and some metal complexes</b> |
| title_fullStr | <b>Spectral characterizations and antibacterial effect of 2-(5-R-1<i>H</i>-benzimidazol-2-yl)-4-methyl/bromo-phenols and some metal complexes</b> |
| title_full_unstemmed | <b>Spectral characterizations and antibacterial effect of 2-(5-R-1<i>H</i>-benzimidazol-2-yl)-4-methyl/bromo-phenols and some metal complexes</b> |
| title_short | <b>Spectral characterizations and antibacterial effect of 2-(5-R-1<i>H</i>-benzimidazol-2-yl)-4-methyl/bromo-phenols and some metal complexes</b> |
| title_sort | b spectral characterizations and antibacterial effect of 2 5 r 1 i h i benzimidazol 2 yl 4 methyl bromo phenols and some metal complexes b |
| topic | Benzimidazole Phenol Metal complexes Antibacterial activity |
| url | http://ajol.info/index.php/bcse/article/view/60686 |
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