Serpinc1 Acts as a Tumor Suppressor in Hepatocellular Carcinoma Through Inducing Apoptosis and Blocking Macrophage Polarization in an Ubiquitin-Proteasome Manner

Serpinc1 Acts as a Tumor Suppressor in Hepatocellular Carcinoma Through Inducing Apoptosis and Blocking Macrophage Polarization in an Ubiquitin-Proteasome Manner

Serpinc1 is a serine protease inhibitor in the coagulation cascade, but its role in tumor biology remains obscure. Here, we report an unexpected role of serpinc1 in suppression of hepatocellular carcinoma (HCC). In HCC patients, the mRNA and protein expression of serpinc1 is upregulated, which is ne...

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Bibliographic Details
Main Authors: Dacai Xu, Jiawen Wu, Liang Dong, Wenwen Luo, Lanying Li, Daolin Tang, Jinbao Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Oncology
Subjects:
serpinc1
apoptosis
liver cancer
macrophage
ubiquitination
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.738607/full

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