Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence
The efficacy of tumour starvation therapy is limited by lack of persistent tumour suppression, tumour metastasis and recurrence. Here, the authors report biocompatible gold nanorods and thermal-sensitive hydrogel to promote narrowing of blood vessels and show this to reduce tumour growth and metasta...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13115-3 |
| _version_ | 1818342186916249600 |
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| author | Kun Zhang Yan Fang Yaping He Haohao Yin Xin Guan Yinying Pu Bangguo Zhou Wenwen Yue Weiwei Ren Dou Du Hongyan Li Chang Liu Liping Sun Yu Chen Huixiong Xu |
| author_facet | Kun Zhang Yan Fang Yaping He Haohao Yin Xin Guan Yinying Pu Bangguo Zhou Wenwen Yue Weiwei Ren Dou Du Hongyan Li Chang Liu Liping Sun Yu Chen Huixiong Xu |
| author_sort | Kun Zhang |
| collection | DOAJ |
| description | The efficacy of tumour starvation therapy is limited by lack of persistent tumour suppression, tumour metastasis and recurrence. Here, the authors report biocompatible gold nanorods and thermal-sensitive hydrogel to promote narrowing of blood vessels and show this to reduce tumour growth and metastasis. |
| first_indexed | 2024-12-13T16:10:42Z |
| format | Article |
| id | doaj.art-bbff732ee41f4a29aee08021301ba0fb |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:10:42Z |
| publishDate | 2019-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-bbff732ee41f4a29aee08021301ba0fb2022-12-21T23:38:57ZengNature PortfolioNature Communications2041-17232019-11-0110111710.1038/s41467-019-13115-3Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrenceKun Zhang0Yan Fang1Yaping He2Haohao Yin3Xin Guan4Yinying Pu5Bangguo Zhou6Wenwen Yue7Weiwei Ren8Dou Du9Hongyan Li10Chang Liu11Liping Sun12Yu Chen13Huixiong Xu14Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji UniversityDepartment of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji UniversityDepartment of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji UniversityDepartment of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji UniversityDepartment of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji UniversityDepartment of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji UniversityDepartment of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji UniversityDepartment of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji UniversityDepartment of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji UniversityDepartment of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji UniversityDepartment of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji UniversityDepartment of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji UniversityDepartment of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji UniversityState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of SciencesDepartment of Medical Ultrasound, Shanghai Tenth People’s Hospital, and Ultrasound Research and Education Institute, Tongji University School of Medicine, Tongji UniversityThe efficacy of tumour starvation therapy is limited by lack of persistent tumour suppression, tumour metastasis and recurrence. Here, the authors report biocompatible gold nanorods and thermal-sensitive hydrogel to promote narrowing of blood vessels and show this to reduce tumour growth and metastasis.https://doi.org/10.1038/s41467-019-13115-3 |
| spellingShingle | Kun Zhang Yan Fang Yaping He Haohao Yin Xin Guan Yinying Pu Bangguo Zhou Wenwen Yue Weiwei Ren Dou Du Hongyan Li Chang Liu Liping Sun Yu Chen Huixiong Xu Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence Nature Communications |
| title | Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence |
| title_full | Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence |
| title_fullStr | Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence |
| title_full_unstemmed | Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence |
| title_short | Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence |
| title_sort | extravascular gelation shrinkage derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence |
| url | https://doi.org/10.1038/s41467-019-13115-3 |
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