DETECTION OF AUTO- AND ALLOANTIBODIES AGAINST GRANULOCYTES BY MEANS OF GEL AGGLUTINATION TECHNIQUE
Аbstract. Granulocyte antigen-specific autoantibodies may be implicated into pathogenesis of autoand alloimmune neutropenia, neonatal alloimmune neutropenia, and acute pulmonary insufficiency occurring post-transfusion. However, detection and identification of clinically significant...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/507 |
| Summary: | Аbstract. Granulocyte antigen-specific autoantibodies may be implicated into pathogenesis of autoand alloimmune neutropenia, neonatal alloimmune neutropenia, and acute pulmonary insufficiency occurring post-transfusion. However, detection and identification of clinically significant granulocyte antibodies still represent a technically difficult task. To detect immunoglobulins and/or activated complement on granulocyte surface, we have adapted a Gel Test (ID Micro Typing System, DiaMed, Switzerland) which is commonly applied for diagnostics of RBC-specific antibodies. Our results suggest that the data from this gel test are quite reproducible, and the system may be used for detection of granulocyte-specific antibodies belonging to different immunoglobulin classes. (Med. Immunol., 2011, vol. 13, N 2-3, pp 253-256) |
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| ISSN: | 1563-0625 2313-741X |