Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study
ABSTRACT Objective To investigate the prevalence of factors related to healthcare-associated infections, caused by multidrug-resistant bacteria, in a pediatric intensive care unit. Methods A retrospective case-control study conducted from January 1, 2007 to December 31, 2018, in São Paulo (SP),...
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
2022-04-01
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| Series: | Einstein (São Paulo) |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082022000100232&tlng=en |
| _version_ | 1817991661759758336 |
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| author | Barbara Barduchi Oliveira da Silva Moacyr Silva Júnior Fernando Gatti de Menezes Eduardo Juan Troster |
| author_facet | Barbara Barduchi Oliveira da Silva Moacyr Silva Júnior Fernando Gatti de Menezes Eduardo Juan Troster |
| author_sort | Barbara Barduchi Oliveira da Silva |
| collection | DOAJ |
| description | ABSTRACT Objective To investigate the prevalence of factors related to healthcare-associated infections, caused by multidrug-resistant bacteria, in a pediatric intensive care unit. Methods A retrospective case-control study conducted from January 1, 2007 to December 31, 2018, in São Paulo (SP), Brazil. The study was carried out at the pediatric intensive care unit of a high-complexity, tertiary care general hospital. The study included patients aged 1 month to 19 years, admitted to the pediatric intensive care unit, diagnosed as healthcare-associated infections. Results There was significant evidence of infection by multidrug-resistant bacteria associated with immunosuppressed patients (p<0.001), in whom the likelihood of multidrug-resistant bacteria infection was estimated to be nine-fold higher than among non-immunosuppressed patients (OR 8.97; 95%CI 2.69-29.94). In the analysis of multiple logistic regression model, we observed that immunosuppressed patients had an 8.5-fold higher chance of multidrug-resistant bacteria infection when compared to non-immunosuppressed patients (OR 8.48; 95%CI 2.54-28.35; p=0.001). There is evidence of association between the Case Group and presence of Gram-positive (p=0.007), coagulase-negative Staphylococcus (p<0.001), and Gram-negative (p=0.041) microorganisms. Conclusion The immunocompromised-state variable is a factor related to healthcare-associated infections caused by multidrug-resistant bacteria, and the Case Group presented higher proportions of Gram-positive microorganisms and coagulase-negative Staphylococcus. |
| first_indexed | 2024-04-14T01:16:09Z |
| format | Article |
| id | doaj.art-bc0135be7dd2445ea800466bb98c1199 |
| institution | Directory Open Access Journal |
| issn | 2317-6385 |
| language | English |
| last_indexed | 2024-04-14T01:16:09Z |
| publishDate | 2022-04-01 |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-bc0135be7dd2445ea800466bb98c11992022-12-22T02:20:51ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-63852022-04-012010.31744/einstein_journal/2022ao6704Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control studyBarbara Barduchi Oliveira da Silvahttps://orcid.org/0000-0002-6507-1817Moacyr Silva Júniorhttps://orcid.org/0000-0002-6479-1708Fernando Gatti de Menezeshttps://orcid.org/0000-0002-0362-5992Eduardo Juan Trosterhttps://orcid.org/0000-0002-9164-9280ABSTRACT Objective To investigate the prevalence of factors related to healthcare-associated infections, caused by multidrug-resistant bacteria, in a pediatric intensive care unit. Methods A retrospective case-control study conducted from January 1, 2007 to December 31, 2018, in São Paulo (SP), Brazil. The study was carried out at the pediatric intensive care unit of a high-complexity, tertiary care general hospital. The study included patients aged 1 month to 19 years, admitted to the pediatric intensive care unit, diagnosed as healthcare-associated infections. Results There was significant evidence of infection by multidrug-resistant bacteria associated with immunosuppressed patients (p<0.001), in whom the likelihood of multidrug-resistant bacteria infection was estimated to be nine-fold higher than among non-immunosuppressed patients (OR 8.97; 95%CI 2.69-29.94). In the analysis of multiple logistic regression model, we observed that immunosuppressed patients had an 8.5-fold higher chance of multidrug-resistant bacteria infection when compared to non-immunosuppressed patients (OR 8.48; 95%CI 2.54-28.35; p=0.001). There is evidence of association between the Case Group and presence of Gram-positive (p=0.007), coagulase-negative Staphylococcus (p<0.001), and Gram-negative (p=0.041) microorganisms. Conclusion The immunocompromised-state variable is a factor related to healthcare-associated infections caused by multidrug-resistant bacteria, and the Case Group presented higher proportions of Gram-positive microorganisms and coagulase-negative Staphylococcus.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082022000100232&tlng=enDrug resistance, multiple, bacterialIntensive care units, pediatricRisk factorsCross infection |
| spellingShingle | Barbara Barduchi Oliveira da Silva Moacyr Silva Júnior Fernando Gatti de Menezes Eduardo Juan Troster Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study Einstein (São Paulo) Drug resistance, multiple, bacterial Intensive care units, pediatric Risk factors Cross infection |
| title | Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study |
| title_full | Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study |
| title_fullStr | Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study |
| title_full_unstemmed | Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study |
| title_short | Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study |
| title_sort | factors associated with multidrug resistant bacteria in healthcare associated infections a pediatric intensive care unit case control study |
| topic | Drug resistance, multiple, bacterial Intensive care units, pediatric Risk factors Cross infection |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082022000100232&tlng=en |
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