Transmission and Colonization of <i>Pneumocystis jirovecii</i>
<i>Pneumocystis</i> spp. was discovered in 1909 and was classified as a fungus in 1988. The species that infects humans is called <i>P. jirovecii</i> and important characteristics of its genome have recently been discovered. Important advances have been made to understand <...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/7/11/979 |
| _version_ | 1797509803950473216 |
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| author | Cristian Vera Zulma Vanessa Rueda |
| author_facet | Cristian Vera Zulma Vanessa Rueda |
| author_sort | Cristian Vera |
| collection | DOAJ |
| description | <i>Pneumocystis</i> spp. was discovered in 1909 and was classified as a fungus in 1988. The species that infects humans is called <i>P. jirovecii</i> and important characteristics of its genome have recently been discovered. Important advances have been made to understand <i>P. jirovecii</i>, including aspects of its biology, evolution, lifecycle, and pathogenesis; it is now considered that the main route of transmission is airborne and that the infectious form is the asci (cyst), but it is unclear whether there is transmission by direct contact or droplet spread. On the other hand, <i>P. jirovecii</i> has been detected in respiratory secretions of hosts without causing disease, which has been termed asymptomatic carrier status or colonization (frequency in immunocompetent patients: 0–65%, pregnancy: 15.5%, children: 0–100%, HIV-positive patients: 20–69%, cystic fibrosis: 1–22%, and COPD: 16–55%). This article briefly describes the history of its discovery and the nomenclature of <i>Pneumocystis</i> spp., recently uncovered characteristics of its genome, and what research has been done on the transmission and colonization of <i>P. jirovecii</i>. Based on the literature, the authors of this review propose a hypothetical natural history of <i>P. jirovecii</i> infection in humans. |
| first_indexed | 2024-03-10T05:22:56Z |
| format | Article |
| id | doaj.art-bc0187bdab4b4cf588ba91a5c28c6e15 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T05:22:56Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-bc0187bdab4b4cf588ba91a5c28c6e152023-11-22T23:56:33ZengMDPI AGJournal of Fungi2309-608X2021-11-0171197910.3390/jof7110979Transmission and Colonization of <i>Pneumocystis jirovecii</i>Cristian Vera0Zulma Vanessa Rueda1Grupo de Investigación en Salud Pública, Research Department, Facultad de Medicina, Universidad Pontificia Bolivariana, Medellín 050031, ColombiaDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg RT3, Colombia<i>Pneumocystis</i> spp. was discovered in 1909 and was classified as a fungus in 1988. The species that infects humans is called <i>P. jirovecii</i> and important characteristics of its genome have recently been discovered. Important advances have been made to understand <i>P. jirovecii</i>, including aspects of its biology, evolution, lifecycle, and pathogenesis; it is now considered that the main route of transmission is airborne and that the infectious form is the asci (cyst), but it is unclear whether there is transmission by direct contact or droplet spread. On the other hand, <i>P. jirovecii</i> has been detected in respiratory secretions of hosts without causing disease, which has been termed asymptomatic carrier status or colonization (frequency in immunocompetent patients: 0–65%, pregnancy: 15.5%, children: 0–100%, HIV-positive patients: 20–69%, cystic fibrosis: 1–22%, and COPD: 16–55%). This article briefly describes the history of its discovery and the nomenclature of <i>Pneumocystis</i> spp., recently uncovered characteristics of its genome, and what research has been done on the transmission and colonization of <i>P. jirovecii</i>. Based on the literature, the authors of this review propose a hypothetical natural history of <i>P. jirovecii</i> infection in humans.https://www.mdpi.com/2309-608X/7/11/979<i>Pneumocystis jirovecii</i>colonizationtransmissionnatural historyepidemiology |
| spellingShingle | Cristian Vera Zulma Vanessa Rueda Transmission and Colonization of <i>Pneumocystis jirovecii</i> Journal of Fungi <i>Pneumocystis jirovecii</i> colonization transmission natural history epidemiology |
| title | Transmission and Colonization of <i>Pneumocystis jirovecii</i> |
| title_full | Transmission and Colonization of <i>Pneumocystis jirovecii</i> |
| title_fullStr | Transmission and Colonization of <i>Pneumocystis jirovecii</i> |
| title_full_unstemmed | Transmission and Colonization of <i>Pneumocystis jirovecii</i> |
| title_short | Transmission and Colonization of <i>Pneumocystis jirovecii</i> |
| title_sort | transmission and colonization of i pneumocystis jirovecii i |
| topic | <i>Pneumocystis jirovecii</i> colonization transmission natural history epidemiology |
| url | https://www.mdpi.com/2309-608X/7/11/979 |
| work_keys_str_mv | AT cristianvera transmissionandcolonizationofipneumocystisjiroveciii AT zulmavanessarueda transmissionandcolonizationofipneumocystisjiroveciii |