Design, Synthesis, Pharmacodynamic and <i>In Silico</i> Pharmacokinetic Evaluation of Some Novel Biginelli-Derived Pyrimidines and Fused Pyrimidines as Calcium Channel Blockers

Design, Synthesis, Pharmacodynamic and <i>In Silico</i> Pharmacokinetic Evaluation of Some Novel Biginelli-Derived Pyrimidines and Fused Pyrimidines as Calcium Channel Blockers

Some new pyrimidine derivatives comprising arylsulfonylhydrazino, ethoxycarbonylhydrazino, thiocarbamoylhydrazino and substituted hydrazone and thiosemicarbazide functionalities were prepared from Biginelli-derived pyrimidine precursors. Heterocyclic ring systems such as pyrazole, pyrazolidinedione,...

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Bibliographic Details
Main Authors: Ahmed M. Farghaly, Ola H. Rizk, Inas Darwish, Manal Hamza, Mezna Saleh Altowyan, Assem Barakat, Mohamed Teleb
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Molecules
Subjects:
pyrimidines
Biginelli
calcium channel blockers
hypotensive activity
Online Access:https://www.mdpi.com/1420-3049/27/7/2240

Internet

https://www.mdpi.com/1420-3049/27/7/2240

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