Do Non-Functional Adrenal Adenomas Affect Metabolic Profile and Carotid Intima-Media Thickness? A Single Centre Study from Poland
<b>Background:</b> Compared to the general population, among people with adrenal incidentalomas (AIs) the diagnosis of obesity, hypertension, impaired carbohydrate and lipid metabolism is more common. The aformentioned disorders represent typical cardiovascular remodeling risk factors. T...
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MDPI AG
2023-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/14/4612 |
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| author | Magdalena Szychlińska Magdalena Rzeczkowska Katarzyna Gontarz-Nowak Wojciech Matuszewski Elżbieta Bandurska-Stankiewicz |
| author_facet | Magdalena Szychlińska Magdalena Rzeczkowska Katarzyna Gontarz-Nowak Wojciech Matuszewski Elżbieta Bandurska-Stankiewicz |
| author_sort | Magdalena Szychlińska |
| collection | DOAJ |
| description | <b>Background:</b> Compared to the general population, among people with adrenal incidentalomas (AIs) the diagnosis of obesity, hypertension, impaired carbohydrate and lipid metabolism is more common. The aformentioned disorders represent typical cardiovascular remodeling risk factors. The study was designed to assess the association between NFAIs, metabolic profile and carotid intima-media thickness (CIMT) as the predictive factor of atherosclerosis. <b>Material:</b> The study included 48 patients with NFAI (16 men, 32 women, mean age 58.6 +/− 9 years) and 44 control participants (15 men, 29 women, mean age 57 +/− 7 years). Both groups were matched for age, gender and BMI. Subjects with history of myocardial infarction, stroke or diabetes mellitus (DM) were excluded. Participants underwent adrenal imaging, biochemical evaluation, and measurement of CIMT. Hormonal evaluation was conducted in AI patients. <b>Results:</b> The NFAI group had significantly higher waist circumference (<i>p</i> < 0.01), higher systolic (<i>p</i> < 0.01) and diastolic blood pressure (<i>p</i> < 0.01), fasting insulin (<i>p</i> = 0.03) and glucose in the 2 h OGTT (<i>p</i> = 0.04) as well as higher CIMT (<i>p</i> < 0.01). Hypertension (<i>p</i> < 0.01) and IGT (<i>p</i> = 0.026) were more common in this group as well. There was a positive correlation between CIMT and cortisol levels in 1 mg dexamethasone suppression test (r = 0.33, <i>p</i> = 0.02). <b>Conclusions:</b> Patients diagnosed with NFAIs, despite normal cortisol inhibition in the 1 mg dexamethasone test, still presented a number of metabolic abnormalities. The assessment of IMT may proove valuable in indicate the presence of early vascular remodelling in asymptomatic patients. The underlying mechanisms of these findings are still unknown, hence further studies are required. |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T00:58:01Z |
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| spelling | doaj.art-bc0337cd0fe649bf96fdf56695d393a52023-11-18T19:51:22ZengMDPI AGJournal of Clinical Medicine2077-03832023-07-011214461210.3390/jcm12144612Do Non-Functional Adrenal Adenomas Affect Metabolic Profile and Carotid Intima-Media Thickness? A Single Centre Study from PolandMagdalena Szychlińska0Magdalena Rzeczkowska1Katarzyna Gontarz-Nowak2Wojciech Matuszewski3Elżbieta Bandurska-Stankiewicz4Clinic of Endocrinology, Diabetology and Internal Medicine, Department of Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-561 Olsztyn, PolandDepartment of Imaging, Provincial Specialist Hospital in Olsztyn, 10-561 Olsztyn, PolandClinic of Endocrinology, Diabetology and Internal Medicine, Department of Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-561 Olsztyn, PolandClinic of Endocrinology, Diabetology and Internal Medicine, Department of Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-561 Olsztyn, PolandClinic of Endocrinology, Diabetology and Internal Medicine, Department of Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-561 Olsztyn, Poland<b>Background:</b> Compared to the general population, among people with adrenal incidentalomas (AIs) the diagnosis of obesity, hypertension, impaired carbohydrate and lipid metabolism is more common. The aformentioned disorders represent typical cardiovascular remodeling risk factors. The study was designed to assess the association between NFAIs, metabolic profile and carotid intima-media thickness (CIMT) as the predictive factor of atherosclerosis. <b>Material:</b> The study included 48 patients with NFAI (16 men, 32 women, mean age 58.6 +/− 9 years) and 44 control participants (15 men, 29 women, mean age 57 +/− 7 years). Both groups were matched for age, gender and BMI. Subjects with history of myocardial infarction, stroke or diabetes mellitus (DM) were excluded. Participants underwent adrenal imaging, biochemical evaluation, and measurement of CIMT. Hormonal evaluation was conducted in AI patients. <b>Results:</b> The NFAI group had significantly higher waist circumference (<i>p</i> < 0.01), higher systolic (<i>p</i> < 0.01) and diastolic blood pressure (<i>p</i> < 0.01), fasting insulin (<i>p</i> = 0.03) and glucose in the 2 h OGTT (<i>p</i> = 0.04) as well as higher CIMT (<i>p</i> < 0.01). Hypertension (<i>p</i> < 0.01) and IGT (<i>p</i> = 0.026) were more common in this group as well. There was a positive correlation between CIMT and cortisol levels in 1 mg dexamethasone suppression test (r = 0.33, <i>p</i> = 0.02). <b>Conclusions:</b> Patients diagnosed with NFAIs, despite normal cortisol inhibition in the 1 mg dexamethasone test, still presented a number of metabolic abnormalities. The assessment of IMT may proove valuable in indicate the presence of early vascular remodelling in asymptomatic patients. The underlying mechanisms of these findings are still unknown, hence further studies are required.https://www.mdpi.com/2077-0383/12/14/4612adrenal incidentalomacarotid-intima media thicknessmetabolic |
| spellingShingle | Magdalena Szychlińska Magdalena Rzeczkowska Katarzyna Gontarz-Nowak Wojciech Matuszewski Elżbieta Bandurska-Stankiewicz Do Non-Functional Adrenal Adenomas Affect Metabolic Profile and Carotid Intima-Media Thickness? A Single Centre Study from Poland Journal of Clinical Medicine adrenal incidentaloma carotid-intima media thickness metabolic |
| title | Do Non-Functional Adrenal Adenomas Affect Metabolic Profile and Carotid Intima-Media Thickness? A Single Centre Study from Poland |
| title_full | Do Non-Functional Adrenal Adenomas Affect Metabolic Profile and Carotid Intima-Media Thickness? A Single Centre Study from Poland |
| title_fullStr | Do Non-Functional Adrenal Adenomas Affect Metabolic Profile and Carotid Intima-Media Thickness? A Single Centre Study from Poland |
| title_full_unstemmed | Do Non-Functional Adrenal Adenomas Affect Metabolic Profile and Carotid Intima-Media Thickness? A Single Centre Study from Poland |
| title_short | Do Non-Functional Adrenal Adenomas Affect Metabolic Profile and Carotid Intima-Media Thickness? A Single Centre Study from Poland |
| title_sort | do non functional adrenal adenomas affect metabolic profile and carotid intima media thickness a single centre study from poland |
| topic | adrenal incidentaloma carotid-intima media thickness metabolic |
| url | https://www.mdpi.com/2077-0383/12/14/4612 |
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