Trends, Symptoms, and Outcomes of Resectable Giant Mediastinal Tumors
Describing the changes in surgical procedures and factors affecting the surgical outcome of patients who have undergone complete resection of giant mediastinal tumors (GMTs, diameter ≥ 10 centimeters) could improve preoperative decision-making and prognostic evaluations. We accessed data from three...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.820720/full |
| _version_ | 1818869993929965568 |
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| author | Xiaoshun Shi Xiguang Liu Xiaoying Dong Hua Wu Kaican Cai |
| author_facet | Xiaoshun Shi Xiguang Liu Xiaoying Dong Hua Wu Kaican Cai |
| author_sort | Xiaoshun Shi |
| collection | DOAJ |
| description | Describing the changes in surgical procedures and factors affecting the surgical outcome of patients who have undergone complete resection of giant mediastinal tumors (GMTs, diameter ≥ 10 centimeters) could improve preoperative decision-making and prognostic evaluations. We accessed data from three sources, which are case reports on surgical treatment of GMTs from PubMed, Web of Science, and EMBASE until June 1, 2019; patients with resected GMT from the Surveillance, Epidemiology, and End Results (SEER) database; and retrospective review of medical records in our institution from 2000 to 2019. The worldwide distribution, clinicopathological characteristics, symptom profile, prognosis of patients with GMT resection, and nomogram for surgical outcome prediction are reported. A total of 242 rare GMT cases from four continents (Asia, North America, South America, and Europe) were included. The median age of the patients was 40 (IQR: 27, range: 13–83) years, and the male-to-female ratio was 1.57:1. Dyspnea, shortness of breath, cough, and chest pain or discomfort were the major symptoms at presentation. The prognosis of benign and low-grade malignant GMTs was superior to that of high-grade malignant GMTs. Tumor malignancy played the most critical role in predicting postoperative survival, followed by longest tumor diameter and a posterior mediastinum location. The findings of this study suggest that the number of successful GMT surgeries has increased over the last decade and describe clinical features of GMTs. Physicians should prioritize tumor malignancy as a leading factor in predicting outcome rather than tumor size. |
| first_indexed | 2024-12-19T11:59:58Z |
| format | Article |
| id | doaj.art-bc067f768cf34dda946f2ad78593c2b1 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-19T11:59:58Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-bc067f768cf34dda946f2ad78593c2b12022-12-21T20:22:32ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-02-011210.3389/fonc.2022.820720820720Trends, Symptoms, and Outcomes of Resectable Giant Mediastinal TumorsXiaoshun ShiXiguang LiuXiaoying DongHua WuKaican CaiDescribing the changes in surgical procedures and factors affecting the surgical outcome of patients who have undergone complete resection of giant mediastinal tumors (GMTs, diameter ≥ 10 centimeters) could improve preoperative decision-making and prognostic evaluations. We accessed data from three sources, which are case reports on surgical treatment of GMTs from PubMed, Web of Science, and EMBASE until June 1, 2019; patients with resected GMT from the Surveillance, Epidemiology, and End Results (SEER) database; and retrospective review of medical records in our institution from 2000 to 2019. The worldwide distribution, clinicopathological characteristics, symptom profile, prognosis of patients with GMT resection, and nomogram for surgical outcome prediction are reported. A total of 242 rare GMT cases from four continents (Asia, North America, South America, and Europe) were included. The median age of the patients was 40 (IQR: 27, range: 13–83) years, and the male-to-female ratio was 1.57:1. Dyspnea, shortness of breath, cough, and chest pain or discomfort were the major symptoms at presentation. The prognosis of benign and low-grade malignant GMTs was superior to that of high-grade malignant GMTs. Tumor malignancy played the most critical role in predicting postoperative survival, followed by longest tumor diameter and a posterior mediastinum location. The findings of this study suggest that the number of successful GMT surgeries has increased over the last decade and describe clinical features of GMTs. Physicians should prioritize tumor malignancy as a leading factor in predicting outcome rather than tumor size.https://www.frontiersin.org/articles/10.3389/fonc.2022.820720/fullgiant mediastinal tumormediastinal malignancyrisk prediction modelsurgical therapyglobal survey |
| spellingShingle | Xiaoshun Shi Xiguang Liu Xiaoying Dong Hua Wu Kaican Cai Trends, Symptoms, and Outcomes of Resectable Giant Mediastinal Tumors Frontiers in Oncology giant mediastinal tumor mediastinal malignancy risk prediction model surgical therapy global survey |
| title | Trends, Symptoms, and Outcomes of Resectable Giant Mediastinal Tumors |
| title_full | Trends, Symptoms, and Outcomes of Resectable Giant Mediastinal Tumors |
| title_fullStr | Trends, Symptoms, and Outcomes of Resectable Giant Mediastinal Tumors |
| title_full_unstemmed | Trends, Symptoms, and Outcomes of Resectable Giant Mediastinal Tumors |
| title_short | Trends, Symptoms, and Outcomes of Resectable Giant Mediastinal Tumors |
| title_sort | trends symptoms and outcomes of resectable giant mediastinal tumors |
| topic | giant mediastinal tumor mediastinal malignancy risk prediction model surgical therapy global survey |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.820720/full |
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