No Genetic Causal Association Between Periodontitis and Arthritis: A Bidirectional Two-Sample Mendelian Randomization Analysis
ObjectivesPeriodontitis (PD) has been linked to arthritis in previous epidemiological observational studies; however, the results are inconclusive. It remains unclear whether the association between PD and arthritis is causal. The purpose of this study was to investigate the causal association of PD...
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.808832/full |
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| author | Kang-Jia Yin Kang-Jia Yin Ji-Xiang Huang Ji-Xiang Huang Peng Wang Peng Wang Xiao-Ke Yang Sha-Sha Tao Sha-Sha Tao Hong-Miao Li Hong-Miao Li Jing Ni Jing Ni Hai-Feng Pan Hai-Feng Pan |
| author_facet | Kang-Jia Yin Kang-Jia Yin Ji-Xiang Huang Ji-Xiang Huang Peng Wang Peng Wang Xiao-Ke Yang Sha-Sha Tao Sha-Sha Tao Hong-Miao Li Hong-Miao Li Jing Ni Jing Ni Hai-Feng Pan Hai-Feng Pan |
| author_sort | Kang-Jia Yin |
| collection | DOAJ |
| description | ObjectivesPeriodontitis (PD) has been linked to arthritis in previous epidemiological observational studies; however, the results are inconclusive. It remains unclear whether the association between PD and arthritis is causal. The purpose of this study was to investigate the causal association of PD with arthritis, including rheumatoid arthritis (RA) and osteoarthritis (OA).MethodsWe performed a two-sample bidirectional Mendelian randomization (MR) analysis using publicly released genome-wide association studies (GWAS) statistics. The inverse-variance weighted (IVW) method was used as the primary analysis. We applied four complementary methods, including weighted median, weighted mode, MR-Egger regression and MR pleiotropy residual sum and outlier (MR-PRESSO) to detect and correct for the effect of horizontal pleiotropy.ResultsGenetically determined PD did not have a causal effect on OA (OR = 1.06, 95% CI: 0.99-1.15, P = 0.09) and RA (OR = 0.99, 95% CI: 0.87-1.13, P = 0.89). Furthermore, we did not find a significant causal effect of arthritis on PD in the reverse MR analysis. The results of MR-Egger regression, Weighted Median, and Weighted Mode methods were consistent with those of the IVW method. Horizontal pleiotropy was unlikely to distort the causal estimates according to the sensitivity analysis.ConclusionsOur MR analysis reveals non-causal association of PD with arthritis, despite observational studies reporting an association between PD and arthritis. |
| first_indexed | 2024-12-13T13:46:47Z |
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| id | doaj.art-bc0745b5e68441d6a85b0872cbc7ab46 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T13:46:47Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-bc0745b5e68441d6a85b0872cbc7ab462022-12-21T23:43:23ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-01-011310.3389/fimmu.2022.808832808832No Genetic Causal Association Between Periodontitis and Arthritis: A Bidirectional Two-Sample Mendelian Randomization AnalysisKang-Jia Yin0Kang-Jia Yin1Ji-Xiang Huang2Ji-Xiang Huang3Peng Wang4Peng Wang5Xiao-Ke Yang6Sha-Sha Tao7Sha-Sha Tao8Hong-Miao Li9Hong-Miao Li10Jing Ni11Jing Ni12Hai-Feng Pan13Hai-Feng Pan14Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, ChinaDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, ChinaObjectivesPeriodontitis (PD) has been linked to arthritis in previous epidemiological observational studies; however, the results are inconclusive. It remains unclear whether the association between PD and arthritis is causal. The purpose of this study was to investigate the causal association of PD with arthritis, including rheumatoid arthritis (RA) and osteoarthritis (OA).MethodsWe performed a two-sample bidirectional Mendelian randomization (MR) analysis using publicly released genome-wide association studies (GWAS) statistics. The inverse-variance weighted (IVW) method was used as the primary analysis. We applied four complementary methods, including weighted median, weighted mode, MR-Egger regression and MR pleiotropy residual sum and outlier (MR-PRESSO) to detect and correct for the effect of horizontal pleiotropy.ResultsGenetically determined PD did not have a causal effect on OA (OR = 1.06, 95% CI: 0.99-1.15, P = 0.09) and RA (OR = 0.99, 95% CI: 0.87-1.13, P = 0.89). Furthermore, we did not find a significant causal effect of arthritis on PD in the reverse MR analysis. The results of MR-Egger regression, Weighted Median, and Weighted Mode methods were consistent with those of the IVW method. Horizontal pleiotropy was unlikely to distort the causal estimates according to the sensitivity analysis.ConclusionsOur MR analysis reveals non-causal association of PD with arthritis, despite observational studies reporting an association between PD and arthritis.https://www.frontiersin.org/articles/10.3389/fimmu.2022.808832/fullperiodontitisosteoarthritisrheumatoid arthritisMendelian randomizationcausal relationship |
| spellingShingle | Kang-Jia Yin Kang-Jia Yin Ji-Xiang Huang Ji-Xiang Huang Peng Wang Peng Wang Xiao-Ke Yang Sha-Sha Tao Sha-Sha Tao Hong-Miao Li Hong-Miao Li Jing Ni Jing Ni Hai-Feng Pan Hai-Feng Pan No Genetic Causal Association Between Periodontitis and Arthritis: A Bidirectional Two-Sample Mendelian Randomization Analysis Frontiers in Immunology periodontitis osteoarthritis rheumatoid arthritis Mendelian randomization causal relationship |
| title | No Genetic Causal Association Between Periodontitis and Arthritis: A Bidirectional Two-Sample Mendelian Randomization Analysis |
| title_full | No Genetic Causal Association Between Periodontitis and Arthritis: A Bidirectional Two-Sample Mendelian Randomization Analysis |
| title_fullStr | No Genetic Causal Association Between Periodontitis and Arthritis: A Bidirectional Two-Sample Mendelian Randomization Analysis |
| title_full_unstemmed | No Genetic Causal Association Between Periodontitis and Arthritis: A Bidirectional Two-Sample Mendelian Randomization Analysis |
| title_short | No Genetic Causal Association Between Periodontitis and Arthritis: A Bidirectional Two-Sample Mendelian Randomization Analysis |
| title_sort | no genetic causal association between periodontitis and arthritis a bidirectional two sample mendelian randomization analysis |
| topic | periodontitis osteoarthritis rheumatoid arthritis Mendelian randomization causal relationship |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.808832/full |
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