NETosis and thrombosis in vaccine-induced immune thrombotic thrombocytopenia

NETosis and thrombosis in vaccine-induced immune thrombotic thrombocytopenia

The mechanisms underlying the pathogenesis of vaccine-induced immune thrombotic thrombocytopenia (VITT) remain unclear. Here the authors show that anti-PF4 antibodies are responsible for the activation of platelets and neutrophils, and blockage of FcγRIIa or NETosis in vivo can prevent thrombosis.

Podrobná bibliografie
Hlavní autoři: Halina H. L. Leung, Jose Perdomo, Zohra Ahmadi, Shiying S. Zheng, Fairooj N. Rashid, Anoop Enjeti, Stephen B. Ting, James J. H. Chong, Beng H. Chong
Médium: Článek
Jazyk:English
Vydáno: Nature Portfolio 2022-09-01
Edice:Nature Communications
On-line přístup:https://doi.org/10.1038/s41467-022-32946-1
Popis
Shrnutí:The mechanisms underlying the pathogenesis of vaccine-induced immune thrombotic thrombocytopenia (VITT) remain unclear. Here the authors show that anti-PF4 antibodies are responsible for the activation of platelets and neutrophils, and blockage of FcγRIIa or NETosis in vivo can prevent thrombosis.
ISSN:2041-1723

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