NETosis and thrombosis in vaccine-induced immune thrombotic thrombocytopenia

NETosis and thrombosis in vaccine-induced immune thrombotic thrombocytopenia

The mechanisms underlying the pathogenesis of vaccine-induced immune thrombotic thrombocytopenia (VITT) remain unclear. Here the authors show that anti-PF4 antibodies are responsible for the activation of platelets and neutrophils, and blockage of FcγRIIa or NETosis in vivo can prevent thrombosis.

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Halina H. L. Leung, Jose Perdomo, Zohra Ahmadi, Shiying S. Zheng, Fairooj N. Rashid, Anoop Enjeti, Stephen B. Ting, James J. H. Chong, Beng H. Chong
Formáid:	Alt
Teanga:	English
Foilsithe / Cruthaithe:	Nature Portfolio 2022-09-01
Sraith:	Nature Communications
Rochtain ar líne:	https://doi.org/10.1038/s41467-022-32946-1

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