NETosis and thrombosis in vaccine-induced immune thrombotic thrombocytopenia

NETosis and thrombosis in vaccine-induced immune thrombotic thrombocytopenia

The mechanisms underlying the pathogenesis of vaccine-induced immune thrombotic thrombocytopenia (VITT) remain unclear. Here the authors show that anti-PF4 antibodies are responsible for the activation of platelets and neutrophils, and blockage of FcγRIIa or NETosis in vivo can prevent thrombosis.

Библиографические подробности
Главные авторы:	Halina H. L. Leung, Jose Perdomo, Zohra Ahmadi, Shiying S. Zheng, Fairooj N. Rashid, Anoop Enjeti, Stephen B. Ting, James J. H. Chong, Beng H. Chong
Формат:	Статья
Язык:	English
Опубликовано:	Nature Portfolio 2022-09-01
Серии:	Nature Communications
Online-ссылка:	https://doi.org/10.1038/s41467-022-32946-1

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