Coagulation status, fibrinolysis, and platelet dynamics in dogs with chronic inflammatory enteropathy
Abstract Background Coagulation status is poorly understood in dogs with chronic inflammatory enteropathy (CIE). Fibrinolytic activity and platelet dynamics have not been evaluated in CIE dogs. Objectives To assess coagulation status and fibrinolysis in normoalbuminemic CIE dogs (CIE‐N) and CIE dogs...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-03-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.16092 |
| _version_ | 1798030078169317376 |
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| author | Sara A. Jablonski Wennogle Christine S. Olver Sarah B. Shropshire |
| author_facet | Sara A. Jablonski Wennogle Christine S. Olver Sarah B. Shropshire |
| author_sort | Sara A. Jablonski Wennogle |
| collection | DOAJ |
| description | Abstract Background Coagulation status is poorly understood in dogs with chronic inflammatory enteropathy (CIE). Fibrinolytic activity and platelet dynamics have not been evaluated in CIE dogs. Objectives To assess coagulation status and fibrinolysis in normoalbuminemic CIE dogs (CIE‐N) and CIE dogs with protein‐losing enteropathy (CIE‐PLE) compared to healthy controls (HC). To evaluate thromboelastography (TEG) variable differences between groups and for correlations with clinicopathologic data. To report platelet dynamics in CIE dogs. Animals Twenty‐five client‐owned dogs with CIE (n = 16 CIE‐N; n = 9 CIE‐PLE); 14 HC beagle dogs. Methods All dogs had tissue factor + tissue plasminogen activator TEG. Nine of 25 CIE dogs had whole blood impedance platelet aggregometry. The TEG variables and coagulation data were compared between all CIE vs HC dogs, CIE‐N dogs vs HC, and CIE‐PLE dogs vs HC. Clinicopathologic and coagulation data were available for CIE dogs and assessed for correlation to TEG variables. Results Dogs with CIE had higher maximum amplitude (MA; P < .001), longer clot lysis times (CLTs; P < .001), lower % lysis after 30 minutes (LY30; P < .001), and % lysis after 60 minutes (LY60; P < .001) compared to HC, suggesting hypercoagulability and hypofibrinolysis. When separated out, both CIE‐N and CIE‐PLE dogs had higher MA, longer CLT, and lower LY30 and LY60 compared to HC. Serum albumin and 25‐hydroxyvitamin D (25[OH]D) concentrations, and plasma antithrombin and fibrinogen concentrations moderately correlated with MA. Conclusions and Clinical Importance Normoalbuminemic and hypoalbuminemic CIE dogs were considered hypercoagulable based on TEG compared to HC. Some CIE dogs displayed hypofibrinolytic phenotypes on TEG. |
| first_indexed | 2024-04-11T19:35:27Z |
| format | Article |
| id | doaj.art-bc0b88d6e8294a8bbf685c5ab045d1c1 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-11T19:35:27Z |
| publishDate | 2021-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-bc0b88d6e8294a8bbf685c5ab045d1c12022-12-22T04:06:53ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762021-03-0135289290110.1111/jvim.16092Coagulation status, fibrinolysis, and platelet dynamics in dogs with chronic inflammatory enteropathySara A. Jablonski Wennogle0Christine S. Olver1Sarah B. Shropshire2Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University Fort Collins Colorado USADepartment of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences Colorado State University Fort Collins Colorado USADepartment of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University Fort Collins Colorado USAAbstract Background Coagulation status is poorly understood in dogs with chronic inflammatory enteropathy (CIE). Fibrinolytic activity and platelet dynamics have not been evaluated in CIE dogs. Objectives To assess coagulation status and fibrinolysis in normoalbuminemic CIE dogs (CIE‐N) and CIE dogs with protein‐losing enteropathy (CIE‐PLE) compared to healthy controls (HC). To evaluate thromboelastography (TEG) variable differences between groups and for correlations with clinicopathologic data. To report platelet dynamics in CIE dogs. Animals Twenty‐five client‐owned dogs with CIE (n = 16 CIE‐N; n = 9 CIE‐PLE); 14 HC beagle dogs. Methods All dogs had tissue factor + tissue plasminogen activator TEG. Nine of 25 CIE dogs had whole blood impedance platelet aggregometry. The TEG variables and coagulation data were compared between all CIE vs HC dogs, CIE‐N dogs vs HC, and CIE‐PLE dogs vs HC. Clinicopathologic and coagulation data were available for CIE dogs and assessed for correlation to TEG variables. Results Dogs with CIE had higher maximum amplitude (MA; P < .001), longer clot lysis times (CLTs; P < .001), lower % lysis after 30 minutes (LY30; P < .001), and % lysis after 60 minutes (LY60; P < .001) compared to HC, suggesting hypercoagulability and hypofibrinolysis. When separated out, both CIE‐N and CIE‐PLE dogs had higher MA, longer CLT, and lower LY30 and LY60 compared to HC. Serum albumin and 25‐hydroxyvitamin D (25[OH]D) concentrations, and plasma antithrombin and fibrinogen concentrations moderately correlated with MA. Conclusions and Clinical Importance Normoalbuminemic and hypoalbuminemic CIE dogs were considered hypercoagulable based on TEG compared to HC. Some CIE dogs displayed hypofibrinolytic phenotypes on TEG.https://doi.org/10.1111/jvim.16092coagulationenteropathyfibrinolysisplatelet dynamicsthromboelastography |
| spellingShingle | Sara A. Jablonski Wennogle Christine S. Olver Sarah B. Shropshire Coagulation status, fibrinolysis, and platelet dynamics in dogs with chronic inflammatory enteropathy Journal of Veterinary Internal Medicine coagulation enteropathy fibrinolysis platelet dynamics thromboelastography |
| title | Coagulation status, fibrinolysis, and platelet dynamics in dogs with chronic inflammatory enteropathy |
| title_full | Coagulation status, fibrinolysis, and platelet dynamics in dogs with chronic inflammatory enteropathy |
| title_fullStr | Coagulation status, fibrinolysis, and platelet dynamics in dogs with chronic inflammatory enteropathy |
| title_full_unstemmed | Coagulation status, fibrinolysis, and platelet dynamics in dogs with chronic inflammatory enteropathy |
| title_short | Coagulation status, fibrinolysis, and platelet dynamics in dogs with chronic inflammatory enteropathy |
| title_sort | coagulation status fibrinolysis and platelet dynamics in dogs with chronic inflammatory enteropathy |
| topic | coagulation enteropathy fibrinolysis platelet dynamics thromboelastography |
| url | https://doi.org/10.1111/jvim.16092 |
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