Heat Shock Protein 22 in Physiological and Pathological Hearts: Small Molecule, Large Potentials
Small heat shock protein 22 (HSP22) belongs to the superfamily of heat shock proteins and is predominantly expressed in the heart, brain, skeletal muscle, and different types of cancers. It has been found that HSP22 is involved in variant cellular functions in cardiomyocytes and plays a vital role i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/1/114 |
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| author | Xiaonan Sun Sharadhi Siri Amirah Hurst Hongyu Qiu |
| author_facet | Xiaonan Sun Sharadhi Siri Amirah Hurst Hongyu Qiu |
| author_sort | Xiaonan Sun |
| collection | DOAJ |
| description | Small heat shock protein 22 (HSP22) belongs to the superfamily of heat shock proteins and is predominantly expressed in the heart, brain, skeletal muscle, and different types of cancers. It has been found that HSP22 is involved in variant cellular functions in cardiomyocytes and plays a vital role in cardiac protection against cardiomyocyte injury under diverse stress. This review summarizes the multiple functions of HSP22 in the heart and the underlying molecular mechanisms through modulating gene transcription, post-translational modification, subcellular translocation of its interacting proteins, and protein degradation, facilitating mitochondrial function, cardiac metabolism, autophagy, and ROS production and antiapoptotic effect. We also discuss the association of HSP22 in cardiac pathologies, including human dilated cardiomyopathy, pressure overload-induced heart failure, ischemic heart diseases, and aging-related cardiac metabolism disorder. The collected information would provide insights into the understanding of the HSP22 in heart diseases and lead to discovering the therapeutic targets. |
| first_indexed | 2024-03-10T03:46:41Z |
| format | Article |
| id | doaj.art-bc0baa6e056d4378a7ba7e5fab147249 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T03:46:41Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-bc0baa6e056d4378a7ba7e5fab1472492023-11-23T11:20:24ZengMDPI AGCells2073-44092021-12-0111111410.3390/cells11010114Heat Shock Protein 22 in Physiological and Pathological Hearts: Small Molecule, Large PotentialsXiaonan Sun0Sharadhi Siri1Amirah Hurst2Hongyu Qiu3Center for Molecular and Translational Medicine, Institute of Biomedical Science, Georgia State University, Atlanta, GA 30303, USACenter for Molecular and Translational Medicine, Institute of Biomedical Science, Georgia State University, Atlanta, GA 30303, USACenter for Molecular and Translational Medicine, Institute of Biomedical Science, Georgia State University, Atlanta, GA 30303, USACenter for Molecular and Translational Medicine, Institute of Biomedical Science, Georgia State University, Atlanta, GA 30303, USASmall heat shock protein 22 (HSP22) belongs to the superfamily of heat shock proteins and is predominantly expressed in the heart, brain, skeletal muscle, and different types of cancers. It has been found that HSP22 is involved in variant cellular functions in cardiomyocytes and plays a vital role in cardiac protection against cardiomyocyte injury under diverse stress. This review summarizes the multiple functions of HSP22 in the heart and the underlying molecular mechanisms through modulating gene transcription, post-translational modification, subcellular translocation of its interacting proteins, and protein degradation, facilitating mitochondrial function, cardiac metabolism, autophagy, and ROS production and antiapoptotic effect. We also discuss the association of HSP22 in cardiac pathologies, including human dilated cardiomyopathy, pressure overload-induced heart failure, ischemic heart diseases, and aging-related cardiac metabolism disorder. The collected information would provide insights into the understanding of the HSP22 in heart diseases and lead to discovering the therapeutic targets.https://www.mdpi.com/2073-4409/11/1/114HSP22cardiomyopathyheartcardiac hypertrophymyocardial ischemiaaging |
| spellingShingle | Xiaonan Sun Sharadhi Siri Amirah Hurst Hongyu Qiu Heat Shock Protein 22 in Physiological and Pathological Hearts: Small Molecule, Large Potentials Cells HSP22 cardiomyopathy heart cardiac hypertrophy myocardial ischemia aging |
| title | Heat Shock Protein 22 in Physiological and Pathological Hearts: Small Molecule, Large Potentials |
| title_full | Heat Shock Protein 22 in Physiological and Pathological Hearts: Small Molecule, Large Potentials |
| title_fullStr | Heat Shock Protein 22 in Physiological and Pathological Hearts: Small Molecule, Large Potentials |
| title_full_unstemmed | Heat Shock Protein 22 in Physiological and Pathological Hearts: Small Molecule, Large Potentials |
| title_short | Heat Shock Protein 22 in Physiological and Pathological Hearts: Small Molecule, Large Potentials |
| title_sort | heat shock protein 22 in physiological and pathological hearts small molecule large potentials |
| topic | HSP22 cardiomyopathy heart cardiac hypertrophy myocardial ischemia aging |
| url | https://www.mdpi.com/2073-4409/11/1/114 |
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