Gut microbiome in multiple myeloma: Mechanisms of progression and clinical applications
The gut commensal microbes modulate human immunity and metabolism through the production of a large number of metabolites, which act as signaling molecules and substrates of metabolic reactions in a diverse range of biological processes. There is a growing appreciation for the importance of immunome...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1058272/full |
| _version_ | 1811300647580991488 |
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| author | Liuyun Zhang Liuyun Zhang Yunhui Xiang Yunhui Xiang Yanying Li Yanying Li Juan Zhang |
| author_facet | Liuyun Zhang Liuyun Zhang Yunhui Xiang Yunhui Xiang Yanying Li Yanying Li Juan Zhang |
| author_sort | Liuyun Zhang |
| collection | DOAJ |
| description | The gut commensal microbes modulate human immunity and metabolism through the production of a large number of metabolites, which act as signaling molecules and substrates of metabolic reactions in a diverse range of biological processes. There is a growing appreciation for the importance of immunometabolic mechanisms of the host-gut microbiota interactions in various malignant tumors. Emerging studies have suggested intestinal microbiota contributes to the progression of multiple myeloma. In this review, we summarized the current understanding of the gut microbiome in MM progression and treatment, and the influence of alterations in gut microbiota on treatment response and treatment-related toxicity and complications in MM patients undergoing hematopoietic stem cell transplantation (HSCT). Furthermore, we discussed the impact of gut microbiota-immune system interactions in tumor immunotherapy, focusing on tumor vaccine immunotherapy, which may be an effective approach to improve anti-myeloma efficacy. |
| first_indexed | 2024-04-13T06:55:18Z |
| format | Article |
| id | doaj.art-bc0e3fdcd301470f94c81f49f58a64d8 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T06:55:18Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-bc0e3fdcd301470f94c81f49f58a64d82022-12-22T02:57:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-12-011310.3389/fimmu.2022.10582721058272Gut microbiome in multiple myeloma: Mechanisms of progression and clinical applicationsLiuyun Zhang0Liuyun Zhang1Yunhui Xiang2Yunhui Xiang3Yanying Li4Yanying Li5Juan Zhang6Department of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaThe gut commensal microbes modulate human immunity and metabolism through the production of a large number of metabolites, which act as signaling molecules and substrates of metabolic reactions in a diverse range of biological processes. There is a growing appreciation for the importance of immunometabolic mechanisms of the host-gut microbiota interactions in various malignant tumors. Emerging studies have suggested intestinal microbiota contributes to the progression of multiple myeloma. In this review, we summarized the current understanding of the gut microbiome in MM progression and treatment, and the influence of alterations in gut microbiota on treatment response and treatment-related toxicity and complications in MM patients undergoing hematopoietic stem cell transplantation (HSCT). Furthermore, we discussed the impact of gut microbiota-immune system interactions in tumor immunotherapy, focusing on tumor vaccine immunotherapy, which may be an effective approach to improve anti-myeloma efficacy.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1058272/fullmultiple myelomagut microbiotahematopoietic stem cell transplantationimmune responsesvaccine immunotherapy |
| spellingShingle | Liuyun Zhang Liuyun Zhang Yunhui Xiang Yunhui Xiang Yanying Li Yanying Li Juan Zhang Gut microbiome in multiple myeloma: Mechanisms of progression and clinical applications Frontiers in Immunology multiple myeloma gut microbiota hematopoietic stem cell transplantation immune responses vaccine immunotherapy |
| title | Gut microbiome in multiple myeloma: Mechanisms of progression and clinical applications |
| title_full | Gut microbiome in multiple myeloma: Mechanisms of progression and clinical applications |
| title_fullStr | Gut microbiome in multiple myeloma: Mechanisms of progression and clinical applications |
| title_full_unstemmed | Gut microbiome in multiple myeloma: Mechanisms of progression and clinical applications |
| title_short | Gut microbiome in multiple myeloma: Mechanisms of progression and clinical applications |
| title_sort | gut microbiome in multiple myeloma mechanisms of progression and clinical applications |
| topic | multiple myeloma gut microbiota hematopoietic stem cell transplantation immune responses vaccine immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1058272/full |
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