Could Histamine H1 Receptor Antagonists Be Used for Treating COVID-19?
COVID-19 has rapidly become a pandemic worldwide, causing extensive and long-term health issues. There is an urgent need to identify therapies that limit SARS-CoV-2 infection and improve the outcome of COVID-19 patients. Unbalanced lung inflammation is a common feature in severe COVID-19 patients; t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/11/5672 |
| _version_ | 1797532547370975232 |
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| author | Changbo Qu Gwenny M. Fuhler Yihang Pan |
| author_facet | Changbo Qu Gwenny M. Fuhler Yihang Pan |
| author_sort | Changbo Qu |
| collection | DOAJ |
| description | COVID-19 has rapidly become a pandemic worldwide, causing extensive and long-term health issues. There is an urgent need to identify therapies that limit SARS-CoV-2 infection and improve the outcome of COVID-19 patients. Unbalanced lung inflammation is a common feature in severe COVID-19 patients; therefore, reducing lung inflammation can undoubtedly benefit the clinical manifestations. Histamine H1 receptor (H1 receptor) antagonists are widely prescribed medications to treat allergic diseases, while recently it has emerged that they show significant promise as anti-SARS-CoV-2 agents. Here, we briefly summarize the novel use of H1 receptor antagonists in combating SARS-CoV-2 infection. We also describe the potential antiviral mechanisms of H1 receptor antagonists on SARS-CoV-2. Finally, the opportunities and challenges of the use of H1 receptor antagonists in managing COVID-19 are discussed. |
| first_indexed | 2024-03-10T11:01:47Z |
| format | Article |
| id | doaj.art-bc0f7be250d34ae7ada6be4985186866 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T11:01:47Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-bc0f7be250d34ae7ada6be49851868662023-11-21T21:30:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-012211567210.3390/ijms22115672Could Histamine H1 Receptor Antagonists Be Used for Treating COVID-19?Changbo Qu0Gwenny M. Fuhler1Yihang Pan2Tomas Lindahl Nobel Laureate Laboratory, Precision Medicine Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, ChinaDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, 3015 CN Rotterdam, The NetherlandsTomas Lindahl Nobel Laureate Laboratory, Precision Medicine Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, ChinaCOVID-19 has rapidly become a pandemic worldwide, causing extensive and long-term health issues. There is an urgent need to identify therapies that limit SARS-CoV-2 infection and improve the outcome of COVID-19 patients. Unbalanced lung inflammation is a common feature in severe COVID-19 patients; therefore, reducing lung inflammation can undoubtedly benefit the clinical manifestations. Histamine H1 receptor (H1 receptor) antagonists are widely prescribed medications to treat allergic diseases, while recently it has emerged that they show significant promise as anti-SARS-CoV-2 agents. Here, we briefly summarize the novel use of H1 receptor antagonists in combating SARS-CoV-2 infection. We also describe the potential antiviral mechanisms of H1 receptor antagonists on SARS-CoV-2. Finally, the opportunities and challenges of the use of H1 receptor antagonists in managing COVID-19 are discussed.https://www.mdpi.com/1422-0067/22/11/5672COVID-19NF-κB signalingH1 receptor antagoniststreatmentdrugs |
| spellingShingle | Changbo Qu Gwenny M. Fuhler Yihang Pan Could Histamine H1 Receptor Antagonists Be Used for Treating COVID-19? International Journal of Molecular Sciences COVID-19 NF-κB signaling H1 receptor antagonists treatment drugs |
| title | Could Histamine H1 Receptor Antagonists Be Used for Treating COVID-19? |
| title_full | Could Histamine H1 Receptor Antagonists Be Used for Treating COVID-19? |
| title_fullStr | Could Histamine H1 Receptor Antagonists Be Used for Treating COVID-19? |
| title_full_unstemmed | Could Histamine H1 Receptor Antagonists Be Used for Treating COVID-19? |
| title_short | Could Histamine H1 Receptor Antagonists Be Used for Treating COVID-19? |
| title_sort | could histamine h1 receptor antagonists be used for treating covid 19 |
| topic | COVID-19 NF-κB signaling H1 receptor antagonists treatment drugs |
| url | https://www.mdpi.com/1422-0067/22/11/5672 |
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