| Summary: | The purpose of the present study was to determine fasting and high-fat meal (HFM)-induced post-prandial systemic inflammation and airway inflammation (exhaled nitric oxide (eNO)) in older adults (OAs) compared to younger adults (YAs) before and after acute exercise. Twelve YAs (23.3 ± 3.9 y <i>n</i> = 5 M/7 F) and 12 OAs (67.7 ± 6 y, <i>n</i> = 8 M/4 F) completed two HFM challenges. After an overnight fast, participants underwent an HFM session or pre-prandial exercise (EX, 65% VO<sub>2Peak</sub> to expend 75% of the caloric content of the HFM) plus HFM (EX + HFM) in a randomized order. Systemic inflammatory cytokines were collected at 0, 3, and 6 h, while eNO was determined at 0, 2, and 4 h after the HFM (12 kcal/kg body weight: 61% fat, 35% CHO, 4% PRO). TNF-α was higher in OAs compared to YAs (<i>p</i> = 0.005) and decreased across time from baseline to 6 h post-HFM (<i>p</i> = 0.007). In response to the HFM, IL-6 decreased from 0 to 3 h but increased at 6 h regardless of age or exercise (<i>p</i> = 0.018). IL-8 or IL-1β did not change over the HFM by age or exercise (<i>p</i> > 0.05). eNO was also elevated in OAs compared to YAs (<i>p</i> = 0.003) but was not altered by exercise (<i>p</i> = 0.108). There was a trend, however, towards significance post-prandially in OAs and YAs from 0 to 2 h (<i>p</i> = 0.072). TNF-α and eNO are higher in OAs compared to YAs but are not elevated more in OAs post-prandially compared to YAs. Primary systemic inflammatory cytokines and eNO were not modified by acute exercise prior to an HFM.
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