Acute Exercise and the Systemic and Airway Inflammatory Response to a High-Fat Meal in Young and Older Adults
The purpose of the present study was to determine fasting and high-fat meal (HFM)-induced post-prandial systemic inflammation and airway inflammation (exhaled nitric oxide (eNO)) in older adults (OAs) compared to younger adults (YAs) before and after acute exercise. Twelve YAs (23.3 ± 3.9 y <i>...
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MDPI AG
2022-09-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/9/853 |
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| author | Stephanie P. Kurti William S. Wisseman Molly E. Miller Hannah L. Frick Steven K. Malin Sam R. Emerson David A. Edwards Elizabeth S. Edwards |
| author_facet | Stephanie P. Kurti William S. Wisseman Molly E. Miller Hannah L. Frick Steven K. Malin Sam R. Emerson David A. Edwards Elizabeth S. Edwards |
| author_sort | Stephanie P. Kurti |
| collection | DOAJ |
| description | The purpose of the present study was to determine fasting and high-fat meal (HFM)-induced post-prandial systemic inflammation and airway inflammation (exhaled nitric oxide (eNO)) in older adults (OAs) compared to younger adults (YAs) before and after acute exercise. Twelve YAs (23.3 ± 3.9 y <i>n</i> = 5 M/7 F) and 12 OAs (67.7 ± 6 y, <i>n</i> = 8 M/4 F) completed two HFM challenges. After an overnight fast, participants underwent an HFM session or pre-prandial exercise (EX, 65% VO<sub>2Peak</sub> to expend 75% of the caloric content of the HFM) plus HFM (EX + HFM) in a randomized order. Systemic inflammatory cytokines were collected at 0, 3, and 6 h, while eNO was determined at 0, 2, and 4 h after the HFM (12 kcal/kg body weight: 61% fat, 35% CHO, 4% PRO). TNF-α was higher in OAs compared to YAs (<i>p</i> = 0.005) and decreased across time from baseline to 6 h post-HFM (<i>p</i> = 0.007). In response to the HFM, IL-6 decreased from 0 to 3 h but increased at 6 h regardless of age or exercise (<i>p</i> = 0.018). IL-8 or IL-1β did not change over the HFM by age or exercise (<i>p</i> > 0.05). eNO was also elevated in OAs compared to YAs (<i>p</i> = 0.003) but was not altered by exercise (<i>p</i> = 0.108). There was a trend, however, towards significance post-prandially in OAs and YAs from 0 to 2 h (<i>p</i> = 0.072). TNF-α and eNO are higher in OAs compared to YAs but are not elevated more in OAs post-prandially compared to YAs. Primary systemic inflammatory cytokines and eNO were not modified by acute exercise prior to an HFM. |
| first_indexed | 2024-03-09T23:11:03Z |
| format | Article |
| id | doaj.art-bc107631d7ee4b859fa8bd177e0b2ede |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T23:11:03Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-bc107631d7ee4b859fa8bd177e0b2ede2023-11-23T17:44:48ZengMDPI AGMetabolites2218-19892022-09-0112985310.3390/metabo12090853Acute Exercise and the Systemic and Airway Inflammatory Response to a High-Fat Meal in Young and Older AdultsStephanie P. Kurti0William S. Wisseman1Molly E. Miller2Hannah L. Frick3Steven K. Malin4Sam R. Emerson5David A. Edwards6Elizabeth S. Edwards7Human Performance Laboratory, Department of Kinesiology, James Madison University, Harrisonburg, VA 22807, USAHuman Performance Laboratory, Department of Kinesiology, James Madison University, Harrisonburg, VA 22807, USAHuman Performance Laboratory, Department of Kinesiology, James Madison University, Harrisonburg, VA 22807, USAHuman Performance Laboratory, Department of Kinesiology, James Madison University, Harrisonburg, VA 22807, USADepartment of Kinesiology and Health, Division of Endocrinology, Metabolism and Nutrition, Rutgers University, Piscataway, NJ 08854, USADepartment of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USADepartment of Kinesiology, University of Virginia, Charlottesville, VA 22904, USAHuman Performance Laboratory, Department of Kinesiology, James Madison University, Harrisonburg, VA 22807, USAThe purpose of the present study was to determine fasting and high-fat meal (HFM)-induced post-prandial systemic inflammation and airway inflammation (exhaled nitric oxide (eNO)) in older adults (OAs) compared to younger adults (YAs) before and after acute exercise. Twelve YAs (23.3 ± 3.9 y <i>n</i> = 5 M/7 F) and 12 OAs (67.7 ± 6 y, <i>n</i> = 8 M/4 F) completed two HFM challenges. After an overnight fast, participants underwent an HFM session or pre-prandial exercise (EX, 65% VO<sub>2Peak</sub> to expend 75% of the caloric content of the HFM) plus HFM (EX + HFM) in a randomized order. Systemic inflammatory cytokines were collected at 0, 3, and 6 h, while eNO was determined at 0, 2, and 4 h after the HFM (12 kcal/kg body weight: 61% fat, 35% CHO, 4% PRO). TNF-α was higher in OAs compared to YAs (<i>p</i> = 0.005) and decreased across time from baseline to 6 h post-HFM (<i>p</i> = 0.007). In response to the HFM, IL-6 decreased from 0 to 3 h but increased at 6 h regardless of age or exercise (<i>p</i> = 0.018). IL-8 or IL-1β did not change over the HFM by age or exercise (<i>p</i> > 0.05). eNO was also elevated in OAs compared to YAs (<i>p</i> = 0.003) but was not altered by exercise (<i>p</i> = 0.108). There was a trend, however, towards significance post-prandially in OAs and YAs from 0 to 2 h (<i>p</i> = 0.072). TNF-α and eNO are higher in OAs compared to YAs but are not elevated more in OAs post-prandially compared to YAs. Primary systemic inflammatory cytokines and eNO were not modified by acute exercise prior to an HFM.https://www.mdpi.com/2218-1989/12/9/853post-prandialaginginflammationairwaysacute exerciseWestern diet |
| spellingShingle | Stephanie P. Kurti William S. Wisseman Molly E. Miller Hannah L. Frick Steven K. Malin Sam R. Emerson David A. Edwards Elizabeth S. Edwards Acute Exercise and the Systemic and Airway Inflammatory Response to a High-Fat Meal in Young and Older Adults Metabolites post-prandial aging inflammation airways acute exercise Western diet |
| title | Acute Exercise and the Systemic and Airway Inflammatory Response to a High-Fat Meal in Young and Older Adults |
| title_full | Acute Exercise and the Systemic and Airway Inflammatory Response to a High-Fat Meal in Young and Older Adults |
| title_fullStr | Acute Exercise and the Systemic and Airway Inflammatory Response to a High-Fat Meal in Young and Older Adults |
| title_full_unstemmed | Acute Exercise and the Systemic and Airway Inflammatory Response to a High-Fat Meal in Young and Older Adults |
| title_short | Acute Exercise and the Systemic and Airway Inflammatory Response to a High-Fat Meal in Young and Older Adults |
| title_sort | acute exercise and the systemic and airway inflammatory response to a high fat meal in young and older adults |
| topic | post-prandial aging inflammation airways acute exercise Western diet |
| url | https://www.mdpi.com/2218-1989/12/9/853 |
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