Interaction of cervical microbiome with epigenome of epithelial cells: Significance of inflammation to primary healthcare
One pillar of the predictive, preventive, and personalized medicine framework strategies is the female health. The evaluation of women’s lifestyle and dietary habits in context with genetic and modifiable risk factors may reflect the prevention of cervical cancer before the occurrence of clinical sy...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-03-01
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| Series: | Biomolecular Concepts |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bmc-2022-0005 |
| _version_ | 1828169906099585024 |
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| author | Holubekova Veronika Kolkova Zuzana Kasubova Ivana Samec Marek Mazurakova Alena Koklesova Lenka Kubatka Peter Rokos Tomas Kozubik Erik Biringer Kamil Kudela Erik |
| author_facet | Holubekova Veronika Kolkova Zuzana Kasubova Ivana Samec Marek Mazurakova Alena Koklesova Lenka Kubatka Peter Rokos Tomas Kozubik Erik Biringer Kamil Kudela Erik |
| author_sort | Holubekova Veronika |
| collection | DOAJ |
| description | One pillar of the predictive, preventive, and personalized medicine framework strategies is the female health. The evaluation of women’s lifestyle and dietary habits in context with genetic and modifiable risk factors may reflect the prevention of cervical cancer before the occurrence of clinical symptoms and prediction of cervical lesion behavior. The main aim of this review is to analyze publications in the field of precision medicine that allow the use of research knowledge of cervical microbiome, epigenetic modifications, and inflammation in potential application in clinical practice. Personalized approach in evaluating patient’s risk of future development of cervical abnormality should consider the biomarkers of the local microenvironment characterized by the microbial composition, epigenetic pattern of cervical epithelium, and presence of chronic inflammation. Novel sequencing techniques enable a more detailed characterization of actual state in cervical epithelium. Better understanding of all changes in multiomics level enables a better assessment of disease prognosis and selects the eligible targeted therapy in personalized medicine. Restoring of healthy vaginal microflora and reversing the outbreak of cervical abnormality can be also achieved by dietary habits as well as uptake of prebiotics, probiotics, synbiotics, microbial transplantation, and others. |
| first_indexed | 2024-04-12T02:59:50Z |
| format | Article |
| id | doaj.art-bc1252abb3ae4edf95ca236f1b5a25c9 |
| institution | Directory Open Access Journal |
| issn | 1868-503X |
| language | English |
| last_indexed | 2024-04-12T02:59:50Z |
| publishDate | 2022-03-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Biomolecular Concepts |
| spelling | doaj.art-bc1252abb3ae4edf95ca236f1b5a25c92022-12-22T03:50:41ZengDe GruyterBiomolecular Concepts1868-503X2022-03-01131618010.1515/bmc-2022-0005Interaction of cervical microbiome with epigenome of epithelial cells: Significance of inflammation to primary healthcareHolubekova Veronika0Kolkova Zuzana1Kasubova Ivana2Samec Marek3Mazurakova Alena4Koklesova Lenka5Kubatka Peter6Rokos Tomas7Kozubik Erik8Biringer Kamil9Kudela Erik10Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, SK-03601, SlovakiaBiomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, SK-03601, SlovakiaBiomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, SK-03601, SlovakiaBiomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, SK-03601, SlovakiaClinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin University Hospital, Martin, SK-03601, SlovakiaClinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin University Hospital, Martin, SK-03601, SlovakiaDepartment of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, SK-03601, SlovakiaClinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin University Hospital, Martin, SK-03601, SlovakiaClinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin University Hospital, Martin, SK-03601, SlovakiaClinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin University Hospital, Martin, SK-03601, SlovakiaClinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin University Hospital, Martin, SK-03601, SlovakiaOne pillar of the predictive, preventive, and personalized medicine framework strategies is the female health. The evaluation of women’s lifestyle and dietary habits in context with genetic and modifiable risk factors may reflect the prevention of cervical cancer before the occurrence of clinical symptoms and prediction of cervical lesion behavior. The main aim of this review is to analyze publications in the field of precision medicine that allow the use of research knowledge of cervical microbiome, epigenetic modifications, and inflammation in potential application in clinical practice. Personalized approach in evaluating patient’s risk of future development of cervical abnormality should consider the biomarkers of the local microenvironment characterized by the microbial composition, epigenetic pattern of cervical epithelium, and presence of chronic inflammation. Novel sequencing techniques enable a more detailed characterization of actual state in cervical epithelium. Better understanding of all changes in multiomics level enables a better assessment of disease prognosis and selects the eligible targeted therapy in personalized medicine. Restoring of healthy vaginal microflora and reversing the outbreak of cervical abnormality can be also achieved by dietary habits as well as uptake of prebiotics, probiotics, synbiotics, microbial transplantation, and others.https://doi.org/10.1515/bmc-2022-0005cervical cancermicrobiomeepigenomeinflammationhuman papillomavirus3p-medicine |
| spellingShingle | Holubekova Veronika Kolkova Zuzana Kasubova Ivana Samec Marek Mazurakova Alena Koklesova Lenka Kubatka Peter Rokos Tomas Kozubik Erik Biringer Kamil Kudela Erik Interaction of cervical microbiome with epigenome of epithelial cells: Significance of inflammation to primary healthcare Biomolecular Concepts cervical cancer microbiome epigenome inflammation human papillomavirus 3p-medicine |
| title | Interaction of cervical microbiome with epigenome of epithelial cells: Significance of inflammation to primary healthcare |
| title_full | Interaction of cervical microbiome with epigenome of epithelial cells: Significance of inflammation to primary healthcare |
| title_fullStr | Interaction of cervical microbiome with epigenome of epithelial cells: Significance of inflammation to primary healthcare |
| title_full_unstemmed | Interaction of cervical microbiome with epigenome of epithelial cells: Significance of inflammation to primary healthcare |
| title_short | Interaction of cervical microbiome with epigenome of epithelial cells: Significance of inflammation to primary healthcare |
| title_sort | interaction of cervical microbiome with epigenome of epithelial cells significance of inflammation to primary healthcare |
| topic | cervical cancer microbiome epigenome inflammation human papillomavirus 3p-medicine |
| url | https://doi.org/10.1515/bmc-2022-0005 |
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